INT69690

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Context Info
Confidence 0.78
First Reported 1997
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 2.08
Pain Relevance 2.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (Scn9a)
Anatomy Link Frequency
embryos 1
retina 1
dorsal root ganglia 1
Scn9a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
sodium channel 15 100.00 Very High Very High Very High
tetrodotoxin 7 100.00 Very High Very High Very High
Nav1.7 2 99.00 Very High Very High Very High
Pain 1 98.36 Very High Very High Very High
dexamethasone 48 95.92 Very High Very High Very High
Limbic system 1 94.56 High High
Root ganglion neuron 2 94.12 High High
Hippocampus 1 93.16 High High
anesthesia 5 89.36 High High
ketamine 11 83.12 Quite High
Disease Link Frequency Relevance Heat
Pain 1 98.36 Very High Very High Very High
Dissociative Disorders 1 96.84 Very High Very High Very High
Bronchopulmonary Dysplasia 18 95.76 Very High Very High Very High
Ganglion Cysts 7 93.80 High High
Rheumatoid Arthritis 46 90.48 High High
Injury 1 87.72 High High
Attention Deficit Hyperactivity Disorder 1 83.44 Quite High
Mental Disorders 1 78.88 Quite High
Borderline Personality 2 77.28 Quite High
Targeted Disruption 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here, we report the cloning from rat, dorsal root ganglia (DRG), cellular expression, and functional analysis of a novel tetrodotoxin-sensitive peripheral sodium channel (PN), PN1.
Gene_expression (expression) of PN1 in dorsal root ganglia associated with tetrodotoxin and sodium channel
1) Confidence 0.78 Published 1997 Journal J. Biol. Chem. Section Abstract Doc Link 9169448 Disease Relevance 0.09 Pain Relevance 0.45
PN1 mRNA is expressed in many different tissues.
Gene_expression (expressed) of PN1
2) Confidence 0.67 Published 1997 Journal J. Biol. Chem. Section Abstract Doc Link 9169448 Disease Relevance 0.09 Pain Relevance 0.45
In this study, we used reverse transcription-polymerase chain reaction (RT-PCR) and restriction enzyme mapping, together with in situ hybridization, to examine the expression of transcripts for sodium channel alpha-subunits I, II, III, NaG, Na6, hNE/PN1 and SNS, and beta-subunits 1 and 2, in the retina of the adult rat.
Spec (examine) Gene_expression (expression) of PN1 in retina associated with sodium channel
3) Confidence 0.65 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9406935 Disease Relevance 0.49 Pain Relevance 0.37
The alpha-subunit of Nav1.7 is encoded by the SCN9A gene on chromosome 2 and variations of SCN9A can lead to complete inability to sense pain.
Gene_expression (variations) of SCN9A associated with pain and nav1.7
4) Confidence 0.57 Published 2008 Journal J Psychiatr Res Section Abstract Doc Link 18439623 Disease Relevance 1.17 Pain Relevance 0.43
Average protein concentrations of E18, E20, PN1, PN7 and PN30 CSF samples were: 2.4, 1.8, 1.5, 1.0 and 0.4 ?
Gene_expression (samples) of PN1
5) Confidence 0.26 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2265671 Disease Relevance 0 Pain Relevance 0.04
Immunoblotting of samples was repeated as follows: SCO of rat and mouse × 10; RF of rat and mouse × 5; rat CSF of E18 and E20 embryos × 5; rat CSF collected at PN1, PN7 and PN30 × 10.
Gene_expression (collected) of PN1 in embryos
6) Confidence 0.26 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2265671 Disease Relevance 0 Pain Relevance 0
Animals were studied at PN1, 5, 10, and 15.
Gene_expression (studied) of PN1
7) Confidence 0.13 Published 2009 Journal Respir Res Section Body Doc Link PMC2739515 Disease Relevance 0.23 Pain Relevance 0.36

General Comments

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