INT69698

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Context Info
Confidence 0.22
First Reported 1997
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.76
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Ctnnbl1) nucleus (Ctnnbl1) enzyme binding (Ctnnbl1)
molecular_function (Ctnnbl1) cellular_component (Ctnnbl1) biological_process (Ctnnbl1)
Anatomy Link Frequency
liver 1
Ctnnbl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 21 92.84 High High
Bile 2 91.00 High High
Inflammation 5 61.24 Quite High
aspirin 3 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
COX-2 inhibitor 1 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Paracetamol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 1 99.16 Very High Very High Very High
Liver Disease 3 97.96 Very High Very High Very High
Cardiovascular Disorder Under Development 6 95.52 Very High Very High Very High
INFLAMMATION 9 92.32 High High
Gallstones 2 84.08 Quite High
Hepatotoxicity 1 75.00 Quite High
Stress 3 56.72 Quite High
Coronary Heart Disease 12 50.00 Quite Low
Cv Unclassified Under Development 7 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Trimetazidine when given in combination with NAP and DOX decreased the levels of serum LDH, and cardiac tissue TBARS, whereas increased the levels of cardiac tissue superoxide dismutase, catalase, and glutathione, less significantly as compared to toxic control group thus indicating that NAP interfered with the protective effect of TMZ in DOX model.
NAP Binding (combination) of
1) Confidence 0.22 Published 2010 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2885640 Disease Relevance 0.15 Pain Relevance 0
Similarly, formation of covalent NAP-protein adducts in perfusate were greater in isoNAG-dosed perfusions.
NAP Binding (formation) of
2) Confidence 0.11 Published 2001 Journal Xenobiotica Section Abstract Doc Link 11513245 Disease Relevance 0.06 Pain Relevance 0.18
Therefore, we explored whether naproxen covalently bound to human serum albumin NAP-HSA) was able to reduce toxicity in an acute model of liver disease induced by endotoxin in rats pretreated with Corynebacterium parvum.
NAP-HSA Spec (whether) Binding (bound) of in liver associated with liver disease and toxicity
3) Confidence 0.06 Published 1997 Journal J Drug Target Section Abstract Doc Link 9169987 Disease Relevance 0.54 Pain Relevance 0.19

General Comments

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