INT6970

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Context Info
Confidence 0.52
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 13
Total Number 13
Disease Relevance 4.94
Pain Relevance 9.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transferase activity, transferring glycosyl groups (St8sia1) Golgi apparatus (St8sia1) lipid metabolic process (St8sia1)
St8sia1 (Mus musculus)
Pain Link Frequency Relevance Heat
analgesia 58 100.00 Very High Very High Very High
antinociception 35 100.00 Very High Very High Very High
antagonist 7 99.92 Very High Very High Very High
GABAergic 6 99.22 Very High Very High Very High
narcan 7 99.20 Very High Very High Very High
Opioid 1 97.12 Very High Very High Very High
tolerance 3 95.76 Very High Very High Very High
Intracerebroventricular 1 94.80 High High
noradrenaline 6 94.68 High High
Clonidine 12 94.00 High High
Disease Link Frequency Relevance Heat
Stress 30 100.00 Very High Very High Very High
Targeted Disruption 6 99.96 Very High Very High Very High
Influenza Virus Infection 67 99.62 Very High Very High Very High
Sprains And Strains 40 97.00 Very High Very High Very High
Shock 4 92.60 High High
Pheochromocytoma 2 88.28 High High
Alzheimer's Dementia 15 87.12 High High
Vascular Disease 1 86.48 High High
Hyperalgesia 1 81.80 Quite High
Nociception 3 78.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Three different intensities of swim stress produced stress-induced antinociception (SIA) in mice which was assessed either by the reduction in the number of abdominal constrictions produced by acetic acid or by an increase in reaction time on a hot-plate.
Gene_expression (produced) of SIA associated with stress and antinociception
1) Confidence 0.52 Published 1990 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 1982301 Disease Relevance 0.35 Pain Relevance 0.66
SIA produced by the mild stress of a 30 s warm water swim was attenuated by idazoxan (0.5-1 mg kg-1), and by yohimbine at a dose (1 mg kg-1) which reduced antinociception produced by clonidine (12.5-50 micrograms kg-1).
Gene_expression (produced) of SIA associated with stress, antinociception and clonidine
2) Confidence 0.52 Published 1990 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 1982301 Disease Relevance 0.35 Pain Relevance 0.95
The most severe stress of a cold water swim produced SIA on the hot-plate which was initially naloxone-insensitive.
Gene_expression (produced) of SIA associated with stress, antinociception and narcan
3) Confidence 0.52 Published 1990 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 1982301 Disease Relevance 0.29 Pain Relevance 1.19
We previously reported the existence of qualitative sex differences in the neurochemical mediation of nonopioid (i.e., naloxone-insensitive) stress-induced analgesia (SIA) produced by forced swims and suggested that female mice possess a sex-specific SIA mechanism.
Gene_expression (produced) of SIA associated with stress, narcan and analgesia
4) Confidence 0.50 Published 1997 Journal J. Neurosci. Section Abstract Doc Link 9315917 Disease Relevance 0.23 Pain Relevance 0.59
We report presently that both the magnitude of stress-induced analgesia (SIA) produced by such i.c.v. injections, and the ability of OFQ/N to antagonize this opioid-mediated SIA, are strain-dependent.
Gene_expression (produced) of SIA associated with stress, sprains and strains, opioid and analgesia
5) Confidence 0.47 Published 1999 Journal Neurosci. Lett. Section Abstract Doc Link 10081970 Disease Relevance 0.66 Pain Relevance 0.99
These results provide further evidence that alpha 2-adrenergic mechanism is involved in the production of SW-SIA.
Gene_expression (production) of SIA associated with analgesia
6) Confidence 0.28 Published 1991 Journal J. Pharmacobio-dyn. Section Abstract Doc Link 1667019 Disease Relevance 0.74 Pain Relevance 1.49
Maximum oxygen consumption (Vo(2)) elicited by swimming in 20 degrees C water or by exposure to -2.5 degrees C in helium-oxygen (Helox) atmosphere is higher in mice selected for low (LA) than for high (HA) stress-induced analgesia (SIA) produced by swimming.
Gene_expression (produced) of SIA associated with stress and analgesia
7) Confidence 0.17 Published 2003 Journal J. Appl. Physiol. Section Abstract Doc Link 12433863 Disease Relevance 0.24 Pain Relevance 0.36
On the other hand, Oikawa et al. (2009) crossbred Tg mice expressing human APP having Swedish and London mutations with GM2-synthase-knockout mice in which GM1, GD1a, GD1b and GT1b were completely missing but GM3 and GD3 were abundantly expressed (Takamiya et al., 1996).
Gene_expression (expressed) of GD3 associated with targeted disruption
8) Confidence 0.14 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2948441 Disease Relevance 0.40 Pain Relevance 0
The production of PSY- and SW-SIA is attributable to the GABAA receptors/Cl- channel mediated mechanism alone, while that of FS-SIA involves both GABAA and GABAB receptor mediated systems.
Gene_expression (production) of SIA associated with analgesia
9) Confidence 0.08 Published 1992 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 1336079 Disease Relevance 0.13 Pain Relevance 1.67
Thus, GABAergic systems play an important role in the production of each SIA; however, the participation of the receptor subtypes in the mechanism was different from each other.
Gene_expression (production) of SIA associated with gabaergic and analgesia
10) Confidence 0.08 Published 1992 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 1336079 Disease Relevance 0.07 Pain Relevance 1.37
and b-series gangliosides (GQ1b, GT1b, GD3 and GD1b) and GD1a have higher affinities for A?
Gene_expression (have) of GD3
11) Confidence 0.07 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2838405 Disease Relevance 0.25 Pain Relevance 0
More importantly, a recent analysis of GD3 synthase-knockout mice cross-bred with AD model mice has suggested that the bona fide gangliosides initiating A?
Gene_expression (synthase) of GD3 associated with targeted disruption
12) Confidence 0.07 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2838405 Disease Relevance 0.25 Pain Relevance 0
All influenza A viruses bind to terminal Sia acid residues expressed on the cellular receptors.
Gene_expression (expressed) of terminal Sia associated with influenza virus infection
13) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2770640 Disease Relevance 0.97 Pain Relevance 0

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