INT69700

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Context Info
Confidence 0.71
First Reported 1997
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 15
Total Number 15
Disease Relevance 4.32
Pain Relevance 5.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (MC1R) plasma membrane (MC1R) signal transducer activity (MC1R)
Anatomy Link Frequency
NHM 4
keratinocytes 2
MC3 1
MC1R (Homo sapiens)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 217 100.00 Very High Very High Very High
antagonist 3 96.32 Very High Very High Very High
Inflammation 5 90.12 High High
Kinase C 2 87.28 High High
cytokine 12 86.80 High High
Inflammatory response 2 80.04 Quite High
agonist 1 75.00 Quite High
addiction 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Melanoma 154 98.60 Very High Very High Very High
Death 15 98.56 Very High Very High Very High
Nevus 31 97.40 Very High Very High Very High
Necrosis 6 92.64 High High
Cancer 18 92.28 High High
INFLAMMATION 7 90.12 High High
Sunburn 14 87.64 High High
T-cell Leukemia 8 79.16 Quite High
Obesity 4 78.24 Quite High
Burns 8 75.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: Notable expression was found for MC1-R, whereas no mRNA for MC2-R and MC3-R was detected; MC4-R and MC5-R mRNA was occasionally detectable but at very low levels.
Transcription (detectable) of MC5-R in MC3
1) Confidence 0.71 Published 2007 Journal Obesity (Silver Spring) Section Body Doc Link 17228030 Disease Relevance 0.16 Pain Relevance 0
Agouti signaling protein reduced, and UVR down regulated dose-dependently MC1R mRNA level in NHM-b and NHM-c.
Transcription (level) of MC1R mRNA in NHM associated with melanocortin 1 receptor
2) Confidence 0.69 Published 2002 Journal Pigment Cell Res. Section Abstract Doc Link 12453185 Disease Relevance 0 Pain Relevance 0.99
Endothelin-1 increased MC1R mRNA level in NHM regardless of their melanin content.
Transcription (level) of MC1R mRNA in NHM associated with melanocortin 1 receptor
3) Confidence 0.69 Published 2002 Journal Pigment Cell Res. Section Abstract Doc Link 12453185 Disease Relevance 0 Pain Relevance 0.82
We demonstrate that: (1) the constitutive activity of MC1R results in elevated intracellular cAMP level, reduced NF-kappaB activity and decreased TNF-alpha transcription; (2) binding of alpha-MSH to MC1R and the subsequent increase in cAMP production do not inhibit TNFalpha-mediated NF-kappaB activation; (3) MC1R signaling is sufficient to strongly inhibit UVB-induced TNF-alpha expression and this inhibitory effect is further enhanced by alpha-MSH stimulation.
Transcription (activity) of MC1R associated with melanocortin 1 receptor
4) Confidence 0.68 Published 2009 Journal Photochem. Photobiol. Section Abstract Doc Link 19656324 Disease Relevance 0.35 Pain Relevance 0.87
We demonstrate that: (1) the constitutive activity of MC1R results in elevated intracellular cAMP level, reduced NF-kappaB activity and decreased TNF-alpha transcription; (2) binding of alpha-MSH to MC1R and the subsequent increase in cAMP production do not inhibit TNFalpha-mediated NF-kappaB activation; (3) MC1R signaling is sufficient to strongly inhibit UVB-induced TNF-alpha expression and this inhibitory effect is further enhanced by alpha-MSH stimulation.
Transcription (transcription) of MC1R associated with melanocortin 1 receptor
5) Confidence 0.68 Published 2009 Journal Photochem. Photobiol. Section Abstract Doc Link 19656324 Disease Relevance 0.34 Pain Relevance 0.87
Contribution of melanocortin receptor exoloops to Agouti-related protein binding.
Transcription (Contribution) of melanocortin receptor
6) Confidence 0.68 Published 1999 Journal J. Biol. Chem. Section Title Doc Link 10318826 Disease Relevance 0 Pain Relevance 0.12
However, further addition of neutralizing antibody caused cell death of both keratinocytes and melanocytes. rADF was shown to induce higher expression in melanocortin-1 receptor (MC1-R) mRNA accompanied by increased binding activity using 125I labeled [Nle4, D-Phe7]-alpha-MSH in melanocytes, leading to the enhanced increment of DNA synthesis.
Transcription (expression) of melanocortin-1 receptor in keratinocytes associated with melanocortin 1 receptor and death
7) Confidence 0.62 Published 1997 Journal Pigment Cell Res. Section Abstract Doc Link 9170166 Disease Relevance 0.42 Pain Relevance 0.10
However, further addition of neutralizing antibody caused cell death of both keratinocytes and melanocytes. rADF was shown to induce higher expression in melanocortin-1 receptor (MC1-R) mRNA accompanied by increased binding activity using 125I labeled [Nle4, D-Phe7]-alpha-MSH in melanocytes, leading to the enhanced increment of DNA synthesis.
Transcription (expression) of MC1-R in keratinocytes associated with melanocortin 1 receptor and death
8) Confidence 0.62 Published 1997 Journal Pigment Cell Res. Section Abstract Doc Link 9170166 Disease Relevance 0.42 Pain Relevance 0.10
In addition, IL-1alpha and -1beta have a small but real inductive effect on MC1-R mRNA expression.
Transcription (expression) of MC1-R
9) Confidence 0.52 Published 1998 Journal Br. J. Dermatol. Section Abstract Doc Link 9767234 Disease Relevance 0.31 Pain Relevance 0.11
Northern blot analysis showed that MC1-R mRNA expression was induced 24 h after UVB irradiation in a dose-dependent manner, and that 24-h treatment with ET-1 also induced an expression of MC1-R mRNA, whereas TNF-alpha downregulated the expression.
Transcription (expression) of MC1-R
10) Confidence 0.52 Published 1998 Journal Br. J. Dermatol. Section Abstract Doc Link 9767234 Disease Relevance 0.33 Pain Relevance 0.11
A total of 23 nonsynonymous MC1R variants were detected in affected and unaffected CDKN2A mutation carriers of the 186 melanoma-prone families, and four of these variants (V60L, V92M, R151C, and R160W) showed a frequency more than 5% in these mutation carriers across all continents.
Neg (unaffected) Transcription (detected) of MC1R associated with melanocortin 1 receptor and melanoma
11) Confidence 0.46 Published 2010 Journal JNCI Journal of the National Cancer Institute Section Body Doc Link PMC2957428 Disease Relevance 1.04 Pain Relevance 0.50
This is the first study to describe MC1R variants among control subjects from the U.S.
Transcription (describe) of MC1R
12) Confidence 0.40 Published 2004 Journal Cancer Epidemiol. Biomarkers Prev. Section Abstract Doc Link 15159314 Disease Relevance 0.13 Pain Relevance 0.07
However, further addition of neutralizing antibody caused cell death of both keratinocytes and melanocytes. rADF was shown to induce higher expression in melanocortin-1 receptor (MC1-R) mRNA accompanied by increased binding activity using 125I labeled [Nle4, D-Phe7]-alpha-MSH in melanocytes, leading to the enhanced increment of DNA synthesis.
Transcription (expression) of melanocortin-1 receptor in melanocytes associated with melanocortin 1 receptor and death
13) Confidence 0.21 Published 1997 Journal Pigment Cell Res. Section Abstract Doc Link 9170166 Disease Relevance 0.42 Pain Relevance 0.10
However, further addition of neutralizing antibody caused cell death of both keratinocytes and melanocytes. rADF was shown to induce higher expression in melanocortin-1 receptor (MC1-R) mRNA accompanied by increased binding activity using 125I labeled [Nle4, D-Phe7]-alpha-MSH in melanocytes, leading to the enhanced increment of DNA synthesis.
Transcription (expression) of MC1-R in melanocytes associated with melanocortin 1 receptor and death
14) Confidence 0.21 Published 1997 Journal Pigment Cell Res. Section Abstract Doc Link 9170166 Disease Relevance 0.42 Pain Relevance 0.10
Our study further shows that MSH regulates Mc1r function at both the mRNA and protein levels, whereas ASP acts only on its translation.
Transcription (mRNA) of Mc1r associated with melanocortin 1 receptor
15) Confidence 0.21 Published 2003 Journal FASEB J. Section Abstract Doc Link 14500544 Disease Relevance 0 Pain Relevance 0.74

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