INT69702

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Context Info
Confidence 0.35
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 11
Disease Relevance 8.81
Pain Relevance 1.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PMAIP1) mitochondrion (PMAIP1) nucleus (PMAIP1)
Anatomy Link Frequency
anterior 1
T cell 1
PMAIP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 30 99.98 Very High Very High Very High
cytokine 29 99.44 Very High Very High Very High
Inflammation 24 92.48 High High
cva 1 77.32 Quite High
Inflammatory mediators 3 71.92 Quite High
melanocortin 1 receptor 1 67.32 Quite High
cINOD 3 66.12 Quite High
imagery 5 60.76 Quite High
Piles 4 50.48 Quite High
Inflammatory response 3 50.00 Quite Low
Disease Link Frequency Relevance Heat
Apoptosis 75 100.00 Very High Very High Very High
Acute-phase Reaction 11 100.00 Very High Very High Very High
T-cell Leukemia 2 100.00 Very High Very High Very High
Injury 6 99.98 Very High Very High Very High
Cancer 93 99.84 Very High Very High Very High
Recurrence 25 99.36 Very High Very High Very High
Skin Cancer 21 99.32 Very High Very High Very High
Mantle-cell Lymphoma 5 98.80 Very High Very High Very High
Chronic Lymphoid Leukemia 2 97.64 Very High Very High Very High
Leukemia 8 95.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Wide local excision was performed in 129 patients, and 172 patients underwent APR.
Positive_regulation (underwent) of APR
1) Confidence 0.35 Published 2007 Journal Dig Dis Sci Section Body Doc Link PMC1914244 Disease Relevance 0.67 Pain Relevance 0.06
Furthermore, in CLL cells aspirin induced an increase in the protein levels of Noxa.
Positive_regulation (increase) of Noxa associated with aspirin
2) Confidence 0.30 Published 2010 Journal Apoptosis Section Abstract Doc Link 19936928 Disease Relevance 0.89 Pain Relevance 0.52
Aspirin increased the mRNA levels of some pro-apoptotic members, such as BIM, NOXA, BMF or PUMA, but their protein levels did not change.
Positive_regulation (increased) of NOXA associated with aspirin and apoptosis
3) Confidence 0.30 Published 2010 Journal Apoptosis Section Abstract Doc Link 19936928 Disease Relevance 1.13 Pain Relevance 0.63
Within the cytokine networking during the surgical trauma-induced APR, IL-6 production is stimulated by the other two cytokines [13].
Positive_regulation (induced) of APR associated with acute-phase reaction, injury and cytokine
4) Confidence 0.29 Published 2006 Journal Immun Ageing Section Body Doc Link PMC1475883 Disease Relevance 1.01 Pain Relevance 0.52
The induction of NOXA is therefore essential to override high Mcl-1 levels and allow for the activation of the apoptotic machinery in response to bortezomib.72 Also, NOXA’s interaction with anti-apoptotic members of the Bcl-2 family causes release of cytochrome c into the cytosol, leading to the activation of caspases and induction of apoptosis (Figure 8).73
Positive_regulation (induction) of NOXA associated with apoptosis
5) Confidence 0.28 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2990320 Disease Relevance 0.89 Pain Relevance 0
Bortezomib induction of NOXA is also seen in melanoma and mantle cell lymphoma cell lines, with antisense NOXA oligonucleotide (but not control) resulting in a decrease in bortezomib induced apoptosis.71,74 Of note, apoptosis/NOXA induction is not induced by conventional chemotherapeutic agents but is induced by other proteasome inhibitors (eg, MG132), suggesting a possible class specific effect.73,75 To understand why NOXA is preferentially induced in tumor cells, the myriad transcription factors with consensus binding sites at the NOXA promoter were restricted to those that are conserved (as NOXA itself is) across mammalian species and also dysregulated by proteasome inhibition and tumorogenesis.
Positive_regulation (induction) of NOXA associated with mantle-cell lymphoma, cancer, apoptosis and skin cancer
6) Confidence 0.28 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2990320 Disease Relevance 0.95 Pain Relevance 0
Indeed, when c-myc levels were decreased by RNA interference, the tumor cell-specific induction of NOXA was abrogated.
Positive_regulation (induction) of NOXA associated with cancer
7) Confidence 0.24 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2990320 Disease Relevance 0.74 Pain Relevance 0
When myeloma cell lines are exposed to bortezomib, the proapoptotic factor NOXA is induced in a concentration dependent manner accompanied by the activation of caspases.
Positive_regulation (induced) of NOXA
8) Confidence 0.19 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2990320 Disease Relevance 0.53 Pain Relevance 0.03
Bortezomib induction of NOXA is also seen in melanoma and mantle cell lymphoma cell lines, with antisense NOXA oligonucleotide (but not control) resulting in a decrease in bortezomib induced apoptosis.71,74 Of note, apoptosis/NOXA induction is not induced by conventional chemotherapeutic agents but is induced by other proteasome inhibitors (eg, MG132), suggesting a possible class specific effect.73,75 To understand why NOXA is preferentially induced in tumor cells, the myriad transcription factors with consensus binding sites at the NOXA promoter were restricted to those that are conserved (as NOXA itself is) across mammalian species and also dysregulated by proteasome inhibition and tumorogenesis.
Positive_regulation (induced) of NOXA associated with mantle-cell lymphoma, cancer, apoptosis and skin cancer
9) Confidence 0.18 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2990320 Disease Relevance 0.97 Pain Relevance 0
The effect of ultraviolet B induced adult T cell leukemia-derived factor/thioredoxin (ADF/TRX) on survival and growth of human melanocytes.
Positive_regulation (induced) of cell leukemia-derived factor/thioredoxin in T cell associated with t-cell leukemia and cytokine
10) Confidence 0.13 Published 1997 Journal Pigment Cell Res. Section Title Doc Link 9170166 Disease Relevance 0.39 Pain Relevance 0.17
One hundred and of thirty-four of them underwent an APR while 46 had a sphincter-preserving ultra-low anterior resection with per anal coloanal anastomosis, combined with defunctioning stomas (40 ileostomies and 6 colostomies).
Positive_regulation (underwent) of APR in anterior
11) Confidence 0.03 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2859360 Disease Relevance 0.63 Pain Relevance 0.06

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