INT69703

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Context Info
Confidence 0.71
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 20
Total Number 21
Disease Relevance 3.57
Pain Relevance 2.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (TXN) transport (TXN) mitochondrion (TXN)
small molecule metabolic process (TXN) cell-cell signaling (TXN) cytoplasm (TXN)
Anatomy Link Frequency
macrophages 4
plasma 2
dendritic cells 2
neuronal 1
HeLa 1
TXN (Homo sapiens)
Pain Link Frequency Relevance Heat
methotrexate 34 100.00 Very High Very High Very High
Inflammation 114 99.20 Very High Very High Very High
Serotonin 4 98.60 Very High Very High Very High
Migraine 3 93.44 High High
cytokine 41 89.28 High High
lidocaine 2 89.04 High High
diclofenac 80 82.32 Quite High
Calcium channel 3 81.92 Quite High
Pain 6 67.60 Quite High
melanocortin 1 receptor 1 65.12 Quite High
Disease Link Frequency Relevance Heat
T-cell Leukemia 2 99.66 Very High Very High Very High
Arteritis 2 99.20 Very High Very High Very High
Stress 51 98.96 Very High Very High Very High
Lung Cancer 1 98.64 Very High Very High Very High
INFLAMMATION 129 97.96 Very High Very High Very High
Viral Infection 39 95.80 Very High Very High Very High
Targeted Disruption 1 95.76 Very High Very High Very High
Leukemia 26 93.56 High High
Headache 3 93.44 High High
Apoptosis 100 90.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Extracellular Trx1 is present in the circulation of healthy subjects and its levels increase under inflammatory conditions, including viral infection (Nakamura et al, 2001a).
Gene_expression (present) of Trx1 associated with inflammation and viral infection
1) Confidence 0.71 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0.57 Pain Relevance 0.13
While mock-transfected HeLa cells did not capture Trx1(CSAAA) on their surface (Figure 4C, lower row), expression of CD30 led to a strong Trx1 surface association and colocalization of both proteins (Figure 4C, upper row).
Gene_expression (expression) of Trx1 in HeLa
2) Confidence 0.61 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0 Pain Relevance 0
Certain Trx1-secreting cell types, including macrophages and dendritic cells, distinctly upregulate expression of Trx1 upon activation (Angelini et al, 2002).
Gene_expression (expression) of Trx1 in dendritic cells
3) Confidence 0.61 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0.08 Pain Relevance 0.04
In contrast, expression of CD95 (Figure 4D), TNFR1 or NGFR (data not shown) did not promote Trx1 interactions with the cell surface, further strengthening the notion that Trx1 reactivity is a specific property of CD30.
Gene_expression (reactivity) of Trx1
4) Confidence 0.61 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0.12 Pain Relevance 0
M Trx1 together with 200 ?
Gene_expression (together) of Trx1
5) Confidence 0.61 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0.12 Pain Relevance 0.03
M DTT or 100 nM human Trx reductase (TrxR)/500 ?
Gene_expression (human) of Trx reductase
6) Confidence 0.61 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0.06 Pain Relevance 0
Certain Trx1-secreting cell types, including macrophages and dendritic cells, distinctly upregulate expression of Trx1 upon activation (Angelini et al, 2002).
Gene_expression (expression) of Trx1 in dendritic cells
7) Confidence 0.61 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0.08 Pain Relevance 0.04
However, plasma Trx1 is oxidized and appears to represent systemic dilution of Trx1 previously released within tissues.
Gene_expression (oxidized) of Trx1 in plasma
8) Confidence 0.61 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0.10 Pain Relevance 0.05
M DTT or 100 nM human Trx reductase (TrxR)/500 ?
Gene_expression (/) of Trx reductase
9) Confidence 0.61 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0.06 Pain Relevance 0
Overall Trx1 concentrations in mammalian tissues can be as high as 20 ?
Gene_expression (Overall) of Trx1
10) Confidence 0.54 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0.09 Pain Relevance 0.04
Overall Trx1 concentrations in mammalian tissues can be as high as 20 ?
Gene_expression (concentrations) of Trx1
11) Confidence 0.54 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0.09 Pain Relevance 0.04
One such antioxidant, adult T cell leukemia-derived factor (ADF), a human homologue of thioredoxin (TRX), was shown to be efficiently produced in and released from cultured normal human keratinocytes after UVB irradiation by Northern and Western blot analyses and enzyme-linked immunoabsorbent assay (ELISA).
Gene_expression (produced) of ADF in keratinocytes associated with t-cell leukemia
12) Confidence 0.50 Published 1997 Journal Pigment Cell Res. Section Abstract Doc Link 9170166 Disease Relevance 0.33 Pain Relevance 0.07
Here we show that the selective PPARalpha activator GW647 significantly increased the Trx-1 mRNA and protein expression in human macrophages as determined by quantitative polymerase chain reaction and Western immunoblotting.
Gene_expression (expression) of Trx-1 mRNA in macrophages
13) Confidence 0.43 Published 2008 Journal J. Mol. Biol. Section Abstract Doc Link 18848838 Disease Relevance 0.18 Pain Relevance 0.05
Together these data indicate that stimulation of PPARalpha in human macrophages might reduce arterial inflammation through differential regulation of the Trx-1 and VDUP-1 gene expression.
Gene_expression (expression) of Trx-1 in macrophages associated with arteritis and inflammation
14) Confidence 0.43 Published 2008 Journal J. Mol. Biol. Section Abstract Doc Link 18848838 Disease Relevance 0.19 Pain Relevance 0.14
Certain Trx1-secreting cell types, including macrophages and dendritic cells, distinctly upregulate expression of Trx1 upon activation (Angelini et al, 2002).
Gene_expression (expression) of Trx1 in macrophages
15) Confidence 0.21 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0.08 Pain Relevance 0.04
Certain Trx1-secreting cell types, including macrophages and dendritic cells, distinctly upregulate expression of Trx1 upon activation (Angelini et al, 2002).
Gene_expression (expression) of Trx1 in macrophages
16) Confidence 0.21 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0.08 Pain Relevance 0.04
Moreover, endogenously produced or exogenously added Trx increases the SOD2 expression in lung carcinoma [31] or neuronal cells [32].
Gene_expression (produced) of Trx in neuronal associated with lung cancer
17) Confidence 0.20 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896885 Disease Relevance 0.10 Pain Relevance 0.18
This same UNC-2/TGF-beta pathway is required for accumulation of normal serotonin levels and stress-induced modulation of tryptophan hydroxylase (tph) expression in the serotonergic chemosensory ADF neurons, but not the NSM neurons.
Gene_expression (expression) of ADF in neurons associated with stress and serotonin
18) Confidence 0.07 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 14675154 Disease Relevance 0.58 Pain Relevance 0.59
Among the 753 patients included, 720 patients started monotherapy (14% methotrexate (MTX), 67% sulphasalazine (SASP), 15% hydroxychloroquine and 4% other DMARDs) and 33 patients received DMARDs combination therapy at baseline, mainly MTX combined with SASP.
Gene_expression (combined) of SASP associated with methotrexate
19) Confidence 0.05 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911884 Disease Relevance 0 Pain Relevance 0.23
Among the 753 patients included, 720 patients started monotherapy (14% methotrexate (MTX), 67% sulphasalazine (SASP), 15% hydroxychloroquine and 4% other DMARDs) and 33 patients received DMARDs combination therapy at baseline, mainly MTX combined with SASP.
Gene_expression (combined) of SASP associated with methotrexate
20) Confidence 0.05 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911884 Disease Relevance 0 Pain Relevance 0.23

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