INT69704

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Context Info
Confidence 0.50
First Reported 1997
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.44
Pain Relevance 1.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (MC1R) plasma membrane (MC1R) signal transducer activity (MC1R)
Anatomy Link Frequency
pigmentation 2
MC1R (Homo sapiens)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 317 100.00 Very High Very High Very High
Inflammation 2 30.40 Quite Low
cytokine 2 25.00 Low Low
addiction 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Melanoma 308 98.08 Very High Very High Very High
Death 9 96.40 Very High Very High Very High
T-cell Leukemia 2 75.00 Quite High
Sunburn 28 72.40 Quite High
Apoptosis 4 32.80 Quite Low
INFLAMMATION 2 30.40 Quite Low
Nevus 62 7.04 Low Low
Cancer 22 5.00 Very Low Very Low Very Low
Burns 14 5.00 Very Low Very Low Very Low
Disease 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, a molecular basis for the link between CDKN2A and MC1R has been provided by in vitro studies that showed that the increased expression of p16INK4a after exposure to ultraviolet radiation is potentiated by ?
Positive_regulation (basis) of MC1R Binding (link) of associated with melanocortin 1 receptor
1) Confidence 0.50 Published 2010 Journal JNCI Journal of the National Cancer Institute Section Body Doc Link PMC2957428 Disease Relevance 0.53 Pain Relevance 0.94
Case–control studies have indicated that part of the association between melanoma risk and MC1R variants remains after stratification of phenotypic features suggesting that the association of MC1R is not exerted entirely through pigmentation (21,46–48).
Neg (not) Positive_regulation (exerted) of MC1R Binding (association) of in pigmentation associated with melanocortin 1 receptor and melanoma
2) Confidence 0.47 Published 2010 Journal JNCI Journal of the National Cancer Institute Section Body Doc Link PMC2957428 Disease Relevance 0.54 Pain Relevance 0.83
Further, it may work as one of the stimulatory factors for UVB-induced melanogenesis by upregulating MSH-R binding activity in combination with the enhanced DNA synthesis by alpha-MSH.
Positive_regulation (upregulating) of MSH-R Binding (activity) of
3) Confidence 0.42 Published 1997 Journal Pigment Cell Res. Section Abstract Doc Link 9170166 Disease Relevance 0.38 Pain Relevance 0.08

General Comments

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