INT69705

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Context Info
Confidence 0.63
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 2.35
Pain Relevance 0.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (TXN) transport (TXN) mitochondrion (TXN)
small molecule metabolic process (TXN) cell-cell signaling (TXN) cytoplasm (TXN)
Anatomy Link Frequency
plasma 2
T cell 2
TXN (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 19 99.44 Very High Very High Very High
member 8 10 98.52 Very High Very High Very High
diclofenac 80 97.28 Very High Very High Very High
Inflammation 40 96.52 Very High Very High Very High
Inflammatory response 5 92.36 High High
rheumatoid arthritis 5 86.44 High High
melanocortin 1 receptor 2 67.68 Quite High
cINOD 9 5.00 Very Low Very Low Very Low
agonist 5 5.00 Very Low Very Low Very Low
Immobilon 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
T-cell Leukemia 4 100.00 Very High Very High Very High
Viral Infection 15 99.80 Very High Very High Very High
INFLAMMATION 47 96.52 Very High Very High Very High
Eczema 5 87.32 High High
Lung Cancer 1 86.72 High High
Rheumatoid Arthritis 5 86.44 High High
Systemic Lupus Erythematosus 5 85.56 High High
Hypersensitivity 5 83.88 Quite High
Autoimmune Disease 5 83.40 Quite High
Infection 10 82.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Likewise, viral infection leads to elevated Trx1 plasma levels and several studies indicate that secreted Trx1 modulates the antiviral inflammatory process (Nakamura et al, 2001b, 2002).
Positive_regulation (elevated) of Trx1 in plasma associated with inflammation and viral infection
1) Confidence 0.63 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 1.15 Pain Relevance 0.21
The pronounced preference of Trx1 for one particular target protein might seem surprising, but could be due to the fact that we assessed Trx1 reactivity of proteins as they are embedded in their natural microenvironment, namely the intact surface of the active plasma membrane of living cells.
Positive_regulation (preference) of Trx1 in plasma
2) Confidence 0.46 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0 Pain Relevance 0.10
Trx1 kinetic trapping is mediated by specific protein–protein interactions
Positive_regulation (mediated) of Trx1
3) Confidence 0.46 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0 Pain Relevance 0
The effect of ultraviolet B induced adult T cell leukemia-derived factor/thioredoxin (ADF/TRX) on survival and growth of human melanocytes.
Positive_regulation (induced) of TRX in T cell associated with t-cell leukemia and cytokine
4) Confidence 0.44 Published 1997 Journal Pigment Cell Res. Section Title Doc Link 9170166 Disease Relevance 0.39 Pain Relevance 0.17
To demonstrate by an independent method that Trx1 attacks and breaks a disulfide bond in CD30, we used thiol-specific cell surface biotinylation to verify that Trx1 activity generates free thiols within the CD30 ectodomain (Supplementary Figure S3).
Positive_regulation (generates) of Trx1
5) Confidence 0.42 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0.16 Pain Relevance 0
Having established the Trx1 kinetic trapping approach for soluble target proteins, we asked whether the kinetic trapping technique can also be applied to the surface of intact cells in culture.
Positive_regulation (established) of Trx1
6) Confidence 0.40 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0 Pain Relevance 0
The addition of increasing concentrations of SsTrx allowed a restoration of the SOD2 level, thus counteracting the effect of diclofenac.
Positive_regulation (increasing) of SsTrx associated with diclofenac
7) Confidence 0.20 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896885 Disease Relevance 0.26 Pain Relevance 0.25
The effect of ultraviolet B induced adult T cell leukemia-derived factor/thioredoxin (ADF/TRX) on survival and growth of human melanocytes.
Positive_regulation (induced) of ADF in T cell associated with t-cell leukemia and cytokine
8) Confidence 0.19 Published 1997 Journal Pigment Cell Res. Section Title Doc Link 9170166 Disease Relevance 0.39 Pain Relevance 0.17

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