INT6971

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Context Info
Confidence 0.44
First Reported 1991
Last Reported 2010
Negated 4
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 3.25
Pain Relevance 10.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transferase activity, transferring glycosyl groups (St8sia1) Golgi apparatus (St8sia1) lipid metabolic process (St8sia1)
Anatomy Link Frequency
foot 1
St8sia1 (Mus musculus)
Pain Link Frequency Relevance Heat
analgesia 90 100.00 Very High Very High Very High
agonist 16 99.38 Very High Very High Very High
antagonist 10 98.60 Very High Very High Very High
Pain 5 98.16 Very High Very High Very High
Clonidine 6 96.44 Very High Very High Very High
Morphine 5 96.40 Very High Very High Very High
tolerance 8 96.00 Very High Very High Very High
GABAergic 15 95.08 Very High Very High Very High
GABA receptor 5 93.84 High High
Antinociceptive 2 87.80 High High
Disease Link Frequency Relevance Heat
Shock 4 100.00 Very High Very High Very High
Amyloid Plaque 5 98.20 Very High Very High Very High
Pain 3 98.16 Very High Very High Very High
Stress 24 98.00 Very High Very High Very High
Cognitive Disorder 6 97.20 Very High Very High Very High
Apoptosis 1 89.92 High High
Neurodegenerative Disease 22 88.96 High High
Adhesions 1 87.48 High High
Vascular Disease 1 76.96 Quite High
Alzheimer's Dementia 7 76.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To clarify the function of b- and c-series gangliosides in pain sensation in vivo, we generated mice in whom the gene for the alpha-2,8-sialyltransferase (GD3 synthase), which is responsible for the generation of all b-series gangliosides as well as c-series gangliosides, was disrupted.
Regulation (responsible) of GD3 synthase associated with pain
1) Confidence 0.44 Published 2005 Journal Pain Section Abstract Doc Link 16150545 Disease Relevance 0.57 Pain Relevance 0.31
Subanalgesic dose, 0.01 to 0.25 mg/kg, of clonidine (CLO), an alpha 2-adrenoceptor agonist, potentiated forced swimming (SW) stress induced analgesia (SIA) and suppressed psychological (PSY)-SIA in a dose dependent manner but did not affect foot-shock (FS)-SIA.
Neg (not) Regulation (affect) of SIA in foot associated with stress, shock, agonist, analgesia and clonidine
2) Confidence 0.12 Published 1991 Journal J. Pharmacobio-dyn. Section Abstract Doc Link 1667019 Disease Relevance 0.78 Pain Relevance 1.52
Targeting GD3-synthase would also have the effect of reducing levels of GQ1b?
Regulation (Targeting) of GD3-synthase
3) Confidence 0.07 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2948441 Disease Relevance 0.59 Pain Relevance 0
On the contrary, CGP 35348, a GABAB receptor antagonist at 20 to 100 mg/kg caused the dose-dependent blockade of FS-SIA, but affected neither PSY- nor SW-SIA.
Neg (nor) Regulation (affected) of SIA associated with antagonist and analgesia
4) Confidence 0.03 Published 1992 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 1336079 Disease Relevance 0.13 Pain Relevance 1.68
Meanwhile, the effects of both drugs on SW-SIA were less than those on PSY- and FS-SIA, namely, bicuculline slightly inhibited it only at 2.0 mg/kg, and picrotoxin did not produce any appreciable effect even at the highest dose.
Regulation (effects) of SIA associated with analgesia
5) Confidence 0.03 Published 1992 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 1336079 Disease Relevance 0.15 Pain Relevance 1.60
Muscimol, a GABAA receptor agonist, at doses of 0.25 to 1.0 mg/kg, affected each SIA differently, suppressed PSY-SIA at 0.25 mg/kg but tended to potentiate it at 1.0 mg/kg, potentiated SW-SIA dose-dependently and did not affect FS-SIA at the doses employed.
Neg (not) Regulation (affect) of SIA associated with agonist and analgesia
6) Confidence 0.03 Published 1992 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 1336079 Disease Relevance 0.16 Pain Relevance 1.35
Baclofen, a GABAB receptor agonist, at 5.0 and 10.0 mg/kg had no influence on each SIA.
Neg (no) Regulation (influence) of SIA associated with agonist and analgesia
7) Confidence 0.03 Published 1992 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 1336079 Disease Relevance 0.14 Pain Relevance 1.70
Muscimol, a GABAA receptor agonist, at doses of 0.25 to 1.0 mg/kg, affected each SIA differently, suppressed PSY-SIA at 0.25 mg/kg but tended to potentiate it at 1.0 mg/kg, potentiated SW-SIA dose-dependently and did not affect FS-SIA at the doses employed.
Regulation (affected) of SIA associated with agonist and analgesia
8) Confidence 0.03 Published 1992 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 1336079 Disease Relevance 0.16 Pain Relevance 1.23
Neither an acute treatment nor 5 daily pretreatments with GE at 100 mg/kg, p.o. affected each SIA.
Regulation (affected) of SIA
9) Confidence 0.03 Published 1992 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 1434134 Disease Relevance 0.58 Pain Relevance 0.64

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