INT69710

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Context Info
Confidence 0.21
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 16
Disease Relevance 9.45
Pain Relevance 2.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell morphogenesis (shg) plasma membrane (shg)
Anatomy Mention Frequency
facial nerve 1
keratinocytes 1
shg (Drosophila melanogaster)
Pain Term Frequency Confidence Heat
intrathecal 2 99.98 Very High Very High Very High
Migraine 220 99.96 Very High Very High Very High
Glutamate 11 99.34 Very High Very High Very High
anesthesia 5 99.32 Very High Very High Very High
endometriosis 13 98.92 Very High Very High Very High
Pain 3 98.88 Very High Very High Very High
Deep tissue 3 97.64 Very High Very High Very High
nMDA receptor 1 97.08 Very High Very High Very High
Crohn's disease 9 96.84 Very High Very High Very High
Peripheral nervous system 3 90.84 High High
Disease Term Frequency Confidence Heat
Adhesions 48 100.00 Very High Very High Very High
Headache 246 99.96 Very High Very High Very High
Cancer 148 99.74 Very High Very High Very High
Breast Cancer 4 99.62 Very High Very High Very High
Endometriosis 16 98.92 Very High Very High Very High
Pain 5 98.88 Very High Very High Very High
Hepatocellular Cancer 9 98.00 Very High Very High Very High
Sprains And Strains 46 97.56 Very High Very High Very High
Disease 114 96.84 Very High Very High Very High
Malignant Neoplastic Disease 7 96.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Rats received intrathecal injections of the stable analog [Ser1]histogranin (SHG), prior to induction of the formalin response.
Gene_expression (injections) of SHG associated with intrathecal
1) Confidence 0.21 Published 1997 Journal Neuroreport Section Abstract Doc Link 9172139 Disease Relevance 0.33 Pain Relevance 0.56
h after single conditioning, or could more simply be due to similar mechanisms of memory storage, without de novo protein-synthesis.
Gene_expression (synthesis) of de novo
2) Confidence 0.06 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC3020398 Disease Relevance 0 Pain Relevance 0
Long-term memory (LTM), formed after spaced trials, requires de novo protein-synthesis, in contrast to anesthesia-resistant memory (ARM), which is formed after single or massed trials (Tully et al., 1994).
Gene_expression (synthesis) of de novo associated with anesthesia
3) Confidence 0.05 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC3020398 Disease Relevance 0.20 Pain Relevance 0.10
Diagnosis of De Novo and Hidden Migraine
Gene_expression (Diagnosis) of De Novo associated with migraine
4) Confidence 0.04 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2906427 Disease Relevance 0.34 Pain Relevance 0.34
As anticipated, the observed prevalence of migraine, 24.7% by clinical judgment-IHS, and 20.4% by MS-Q questionnaire, was higher than the prevalence reported in studies conducted in general population samples [33-37], as non-selected patients attending PC centers were included. 5.7% of the patients attending a visit had a MS-Q diagnosis of de novo migraine.
Gene_expression (diagnosis) of de novo associated with migraine
5) Confidence 0.04 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2906427 Disease Relevance 0.68 Pain Relevance 0.68
Additionally, expression of two putative Cry1-receptor proteins, cadherin and aminopeptidase, was similar in the control and selected strains.
Gene_expression (expression) of cadherin associated with sprains and strains
6) Confidence 0.01 Published 2006 Journal Journal of Insect Science Section Body Doc Link PMC2990333 Disease Relevance 0.60 Pain Relevance 0
Cadherin expression in gastrointestinal tract endometriosis: possible role in deep tissue invasion and development of malignancy.
Gene_expression (expression) of Cadherin associated with endometriosis, malignant neoplastic disease and deep tissue
7) Confidence 0.01 Published 2010 Journal Mod. Pathol. Section Title Doc Link 19898423 Disease Relevance 1.16 Pain Relevance 0.49
We investigated in the rat the effect of axotomy on the different subunits of excitatory glutamatergic AMPA (GLuR1-4), NMDA (NR1, NR2A-D) receptors, post-synaptic density 95, vesicular glutamate transporter 2, beta catenin and cadherin. mRNA levels and/or protein production were analyzed 1, 3, 8, 30 and 60 days after facial nerve axotomy by in situ hybridization and immunohistofluorescence. mRNAs coding for the GLuR2-4, NR1, NR2A, B, D subunits of glutamatergic receptors and for post-synaptic density 95, were less abundant after axotomy.
Gene_expression (production) of cadherin in facial nerve associated with glutamate
8) Confidence 0.01 Published 2005 Journal Neuroscience Section Abstract Doc Link 16182453 Disease Relevance 0 Pain Relevance 0.13
Moreover, IND 12 treatment induces the expression at membranes of the cell adhesion protein E-cadherin and increases the level of the E-cadherin-bound beta-catenin.
Gene_expression (expression) of protein E-cadherin associated with adhesions
9) Confidence 0.01 Published 2002 Journal Cancer Res. Section Abstract Doc Link 11912145 Disease Relevance 0.45 Pain Relevance 0.08
Moreover, IND 12 treatment induces the expression at membranes of the cell adhesion protein E-cadherin and increases the level of the E-cadherin-bound beta-catenin.
Gene_expression (expression) of protein E-cadherin associated with adhesions
10) Confidence 0.01 Published 2002 Journal Cancer Res. Section Abstract Doc Link 11912145 Disease Relevance 0.45 Pain Relevance 0.08
As shown in Fig. 2, abnormal adherens and desmosomal junctions were found in ADPKD: intracellular junctions were devoid of desmosomal cadherins and associated proteins, which were sequestered to the cytoplasmic pools, and adherens junctions appeared disrupted, accompanied by a great reduction of Ecadherin expression and partial compensatory expression of N-cadherin [68].
Gene_expression (expression) of Ecadherin associated with polycystic kidney disease
11) Confidence 0.01 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2775119 Disease Relevance 1.02 Pain Relevance 0
Molecular determinants of tumor cell invasiveness, such as cadherin expression, probably play a role.
Gene_expression (expression) of cadherin associated with cancer
12) Confidence 0.01 Published 2006 Journal Radiat Oncol Section Body Doc Link PMC1764894 Disease Relevance 0.84 Pain Relevance 0
Vitamin D has been shown in breast carcinoma cells to increase cadherin expression, thereby decreasing cytosolic ?
Gene_expression (expression) of cadherin associated with breast cancer
13) Confidence 0.01 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 1.01 Pain Relevance 0.07
Both agents suppressed cell proliferation in HCCs, without any alteration of pan-cadherin expression.
Gene_expression (expression) of pan-cadherin
14) Confidence 0.01 Published 2002 Journal Jpn. J. Cancer Res. Section Abstract Doc Link 12417048 Disease Relevance 1.40 Pain Relevance 0.12
Overexpression of a dominant negative cadherin in keratinocytes likewise impaired desmosome formation [34].
Gene_expression (Overexpression) of cadherin in keratinocytes
15) Confidence 0.01 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2868981 Disease Relevance 0.08 Pain Relevance 0.04
Moreover, during progression of colorectal and other tumors a switch in cadherin expression from E-cadherin to N-cadherin is observed coinciding with the transition from an epithelial to a mesenchymal phenotype leading to an increase in the invasive capabilities of cancer cells [6] and inactivation of one E-cadherin allele enhances tumor initiation in mice carrying a mutated adenomatous polyposis coli (APC) gene [13].
Gene_expression (expression) of cadherin associated with cancer and familial adenomatous polyposis
16) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001873 Disease Relevance 0.89 Pain Relevance 0.13

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