INT69723

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Context Info
Confidence 0.60
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 4.54
Pain Relevance 1.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SERPINB2) extracellular region (SERPINB2) Golgi apparatus (SERPINB2)
plasma membrane (SERPINB2) cytoplasm (SERPINB2)
Anatomy Link Frequency
connective 1
lungs 1
heart 1
SERPINB2 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 15 99.60 Very High Very High Very High
Angina 4 98.88 Very High Very High Very High
fibrosis 79 98.68 Very High Very High Very High
Inflammation 117 97.80 Very High Very High Very High
cytokine 16 88.64 High High
ischemia 3 85.68 High High
Inflammatory response 4 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Coronary Artery Disease 8 99.32 Very High Very High Very High
Osteogenic Sarcomas 6 99.06 Very High Very High Very High
Cv General 3 Under Development 4 98.88 Very High Very High Very High
Pulmonary Fibrosis 63 98.68 Very High Very High Very High
INFLAMMATION 122 97.80 Very High Very High Very High
Apoptosis 36 95.92 Very High Very High Very High
Thrombophilia 1 91.32 High High
Periodontitis 48 90.72 High High
Pneumonia 3 89.52 High High
Down Syndrome 6 87.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
[Chronic intermittent urokinase therapy: anti-ischemic and hemodynamic effects].
Gene_expression (therapy) of urokinase
1) Confidence 0.60 Published 1997 Journal Z Kardiol Section Title Doc Link 9173724 Disease Relevance 0.51 Pain Relevance 0.21
[Assessment of the anti-ischemic effect in patients with therapy refractory angina pectoris in end-stage coronary heart disease--results of chronic intermittent urokinase therapy].
Gene_expression (therapy) of urokinase in heart associated with angina and coronary artery disease
2) Confidence 0.52 Published 1998 Journal Z Kardiol Section Title Doc Link 9827480 Disease Relevance 0.71 Pain Relevance 0.27
PAI-2 has been identified as a potential biomarker for invasive HNSCC, since PAI-2 expression at both mRNA and protein levels decreased dramatically in cultured HNSCC cells as well as in HNSCC biopsy specimens when invasion into the underlying connective stroma occurred [20].
Gene_expression (expression) of PAI-2 in connective
3) Confidence 0.19 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956083 Disease Relevance 0.46 Pain Relevance 0
Tissue factor and PAI-1 and PAI-2 are thus both strongly expressed by alveolar epithelial cells in IPF lungs [39,40,41].
Gene_expression (expressed) of PAI-2 in lungs associated with fibrosis
4) Confidence 0.11 Published 2002 Journal Respir Res Section Body Doc Link PMC64814 Disease Relevance 0.88 Pain Relevance 0.29
(Cxcl-3), Inhibitor of apoptosis protein-1 (BIRC-1), Cluster of differentiation antigen 38 (CD38), Regulator of G-protein signalling-1 (RGS-1), and Finkel-Biskis-Jinkins murine osteosarcoma virus oncogene (C-FOS); the 5% least strongly expressed genes were Receptor-interacting Serine/Threonine Kinase-2 (RIP-2), Complement component 3 (C3), Prostaglandin-endoperoxide synthase-2 (COX-2), Interleukin-8 (IL-8), Endothelin-1 (EDN-1), Plasminogen activator inhibitor type-2 (PAI-2), Matrix-metalloproteinase-14 (MMP-14), and Interferon regulating factor-7 (IRF-7).


Gene_expression (expressed) of PAI-2 associated with metalloproteinase, osteogenic sarcomas and apoptosis
5) Confidence 0.04 Published 2008 Journal BMC Med Genomics Section Abstract Doc Link PMC2491649 Disease Relevance 0.62 Pain Relevance 0.16
The same interpretation can be applied to the result of decreased expression of END-1 and PAI-2, since they are usually up-regulated when periodontal inflammation exists [38-40].
Gene_expression (expression) of PAI-2 associated with inflammation
6) Confidence 0.04 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2491649 Disease Relevance 0.67 Pain Relevance 0.27
The 5% least expressed genes were Receptor-interacting serine/threonine kinase-2 (RIP-2, NM_003821, 0.01-fold), Complement component 3 (C3, NM_000064, 0.02-fold), Prostaglandin-endoperoxide synthase-2 (COX-2, NM_000963, 0.02-fold), Interleukin-8 (IL-8, NM_000584, 0.02-fold), Endothelin-1 (EDN-1, NM_001955, 0.03-fold), Plasminogen activator inhibitor type-2 (PAI-2, NM_000602, 0.04-fold), Matrixmetalloproteinase-14 (MMP-14, NM_004995, 0.04-fold), and Interferon regulating factor-7 (IRF-7, NM_00157, 0.05-fold) (Figure 1, 2, 3).
Gene_expression (expressed) of PAI-2
7) Confidence 0.04 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2491649 Disease Relevance 0.68 Pain Relevance 0.08

General Comments

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