INT69727

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Context Info
Confidence 0.65
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 18
Total Number 19
Disease Relevance 5.45
Pain Relevance 3.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (QPCT) protein modification process (QPCT) extracellular region (QPCT)
transferase activity, transferring acyl groups (QPCT)
Anatomy Link Frequency
GCT 2
endothelial cell 1
brain 1
lung 1
left atrium 1
QPCT (Homo sapiens)
Pain Link Frequency Relevance Heat
Transcranial magnetic stimulation 910 100.00 Very High Very High Very High
Pain 5 98.12 Very High Very High Very High
spinal inflammation 6 97.64 Very High Very High Very High
Immobilon 10 82.00 Quite High
antagonist 50 79.36 Quite High
opiate 45 78.92 Quite High
aspirin 56 74.08 Quite High
imagery 50 73.64 Quite High
Opioid 25 73.12 Quite High
MU agonist 5 69.76 Quite High
Disease Link Frequency Relevance Heat
Esophageal Cancer 14 100.00 Very High Very High Very High
Malignant Neoplastic Disease 5 99.98 Very High Very High Very High
Arrhythmias 2 Under Development 30 99.52 Very High Very High Very High
Pain 15 98.12 Very High Very High Very High
Recurrence 1 97.96 Very High Very High Very High
Low Back Pain 6 97.64 Very High Very High Very High
Aggression 1 93.64 High High
Amputation 2 89.32 High High
Dysphagia 5 88.72 High High
Weight Loss 4 87.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The microsatellite allele consisting of 4 repetitions of GCT/AGC was present at significantly higher frequency in the patient group (Pc<0.0000001) than in the ethnically matched control group.
Gene_expression (present) of GCT in GCT
1) Confidence 0.65 Published 1997 Journal Tissue Antigens Section Abstract Doc Link 9174144 Disease Relevance 0.43 Pain Relevance 0.48
The recurrence of pain and aggravation of bone destruction many years after the primary treatment suggest malignant transformation of GCT.
Gene_expression (transformation) of GCT in GCT associated with pain, malignant neoplastic disease and recurrence
2) Confidence 0.65 Published 2006 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 16434839 Disease Relevance 1.43 Pain Relevance 0.26
Studies revealed that EC based microcapsules were larger than CAP, and EC + CAP based microcapsules.
Gene_expression (larger) of EC
3) Confidence 0.12 Published 2010 Journal Scientia Pharmaceutica Section Body Doc Link PMC3002828 Disease Relevance 0 Pain Relevance 0.10
Here, we will present a rare case, a patient with AF who was diagnosed with EC compressing the left atrium.


Gene_expression (compressing) of EC in left atrium associated with arrhythmias 2 under development and esophageal cancer
4) Confidence 0.10 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2546416 Disease Relevance 2.30 Pain Relevance 0.03
PPC information flow occurs in between 267 and 367 ms, and the apparent contradiction between fMRI EC and TMS chronometry was due to our design, or 2) TMS chronometry and fMRI EC measured different aspects of brain function, which means that they were complementary rather than competitive; the first option is implausible and the second remains.
Gene_expression (chronometry) of fMRI EC in brain associated with transcranial magnetic stimulation
5) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789405 Disease Relevance 0 Pain Relevance 0.26
And fourth, specifically; how do the causality and information flow analyses of fMRI EC and TMS chronometry relate?
Gene_expression (chronometry) of fMRI EC associated with transcranial magnetic stimulation
6) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789405 Disease Relevance 0 Pain Relevance 0.39
It has been shown previously that with the current fMRI EC analysis (GCM) and fMRI parameters (TR?
Gene_expression (analysis) of fMRI EC
7) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789405 Disease Relevance 0 Pain Relevance 0.17
Importantly, this finding is still not corroborated by the fMRI EC result of MFG?
Gene_expression (result) of fMRI EC
8) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789405 Disease Relevance 0 Pain Relevance 0.21
To summarize, out of these two intriguing possibilities; 1) fMRI EC analysis has a temporal resolution below 100 ms, the MFG?
Gene_expression (analysis) of fMRI EC
9) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789405 Disease Relevance 0 Pain Relevance 0.21
However, to prove this hypothesis, we will need to perform special studies using the substances affecting the integrity of the endothelial monolayer and our EC model expressing EB3-GFP.
Gene_expression (expressing) of EC
10) Confidence 0.09 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2860155 Disease Relevance 0.08 Pain Relevance 0
The results obtained using EC expressing EB3-GFP visually demonstrated that growing microtubule plus-ends were distributed in a relatively uniform manner in a single human EC as well as in a cell in monolayer where cell-cell contacts, mainly AJs, were formed and well-organized.
Gene_expression (using) of EC
11) Confidence 0.09 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2860155 Disease Relevance 0 Pain Relevance 0
The histogram of centrosomal microtubules growth rate distribution demonstrated two peaks in single human EC: the first peak showed a correlation with a growth rate near 18┬ľ20??
Gene_expression (single) of EC
12) Confidence 0.09 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2860155 Disease Relevance 0 Pain Relevance 0
Microtubules Growth Rate Alteration in Human Endothelial Cells

To understand how microtubules contribute to the dynamic reorganization of the endothelial cell (EC) cytoskeleton, we established an EC model expressing EB3-GFP, a protein that marks microtubule plus-ends.

Gene_expression (expressing) of EC in endothelial cell
13) Confidence 0.08 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Title Doc Link PMC2860155 Disease Relevance 0 Pain Relevance 0
Studies revealed that EC based microcapsules were larger than CAP, and EC + CAP based microcapsules.
Gene_expression (larger) of EC
14) Confidence 0.05 Published 2010 Journal Scientia Pharmaceutica Section Body Doc Link PMC3002828 Disease Relevance 0 Pain Relevance 0.10
Specifically, MNTX inhibited EC proliferation with an IC50 of ~100 nM.
Gene_expression (proliferation) of EC
15) Confidence 0.05 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2831839 Disease Relevance 0.65 Pain Relevance 0.30
Src regulates several potential angiogenic events including EC contraction and vascular permeability [43,44].
Gene_expression (contraction) of EC
16) Confidence 0.05 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2831839 Disease Relevance 0 Pain Relevance 0
Adding 10 nM MNTX shifted the IC50 of temsirolimus on EC proliferation from ~10 nM to ~1 nM.
Gene_expression (proliferation) of EC
17) Confidence 0.05 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2831839 Disease Relevance 0.51 Pain Relevance 0.28
There was a shift in the IC50 on inhibition of VEGF-induced EC proliferation and migration with MNTX and rapamycin.
Gene_expression (proliferation) of EC
18) Confidence 0.05 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2831839 Disease Relevance 0 Pain Relevance 0.23
Briefly, human lung EC were transfected with siRNA using siPORTamine™ as the transfection reagent (Ambion, TX).
Gene_expression (transfected) of EC in lung
19) Confidence 0.05 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2831839 Disease Relevance 0 Pain Relevance 0.04

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