INT69742

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Context Info
Confidence 0.69
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 12
Total Number 13
Disease Relevance 8.29
Pain Relevance 8.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Hmox2) endoplasmic reticulum (Hmox2) plasma membrane (Hmox2)
Anatomy Link Frequency
spinal cord 8
spinal 4
stomach 4
gray matter 2
colon 2
Hmox2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
COX2 9 100.00 Very High Very High Very High
cINOD 53 99.98 Very High Very High Very High
aspirin 3 99.98 Very High Very High Very High
endometriosis 14 99.92 Very High Very High Very High
Spinal cord 23 99.84 Very High Very High Very High
Hyperalgesia 3 99.60 Very High Very High Very High
Arthritis 5 99.48 Very High Very High Very High
alcohol 1 97.72 Very High Very High Very High
IPN 2 97.24 Very High Very High Very High
diclofenac 6 95.00 High High
Disease Link Frequency Relevance Heat
Endometriosis 18 99.92 Very High Very High Very High
Hyperalgesia 3 99.60 Very High Very High Very High
Arthritis 5 99.48 Very High Very High Very High
Cancer 4 99.08 Very High Very High Very High
Nicotine Addiction 1 98.08 Very High Very High Very High
Colon Cancer 6 97.68 Very High Very High Very High
Keratosis 1 97.64 Very High Very High Very High
Inflammatory Pain 2 97.24 Very High Very High Very High
INFLAMMATION 18 93.36 High High
Apoptosis 7 92.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ligation of spinal nerves in rats resulted in an upregulation of HO-2 expression which was most pronounced in the ipsilateral gray matter of the spinal cord compared to the contralateral side.
Positive_regulation (upregulation) of Gene_expression (expression) of HO-2 in gray matter associated with spinal cord
1) Confidence 0.69 Published 2000 Journal Amino Acids Section Abstract Doc Link 11026508 Disease Relevance 0.09 Pain Relevance 0.33
Sham operated rats did not show an upregulation of HO-2 expression and the structural changes in the spinal cord were absent.
Positive_regulation (upregulation) of Gene_expression (expression) of HO-2 in spinal cord associated with spinal cord
2) Confidence 0.69 Published 2000 Journal Amino Acids Section Abstract Doc Link 11026508 Disease Relevance 0.08 Pain Relevance 0.33
In addition, it is proposed that the increased expression of the cyclo-oxygenase 2 enzyme is central to the predisposition to both oesophageal and colon cancers.
Positive_regulation (increased) of Gene_expression (expression) of cyclo-oxygenase 2 enzyme in colon associated with colon cancer
3) Confidence 0.62 Published 1998 Journal Eur. J. Cancer Prev. Section Abstract Doc Link 9696927 Disease Relevance 1.09 Pain Relevance 0.26
The results show that there is a tonic release of immunoreactive prostaglandin E2 from the spinal cord following the induction of arthritis, which is accompanied by enhanced expression of cyclo-oxygenase-2 protein in the spinal cord.
Positive_regulation (enhanced) of Gene_expression (expression) of cyclo-oxygenase-2 in spinal cord associated with arthritis and spinal cord
4) Confidence 0.43 Published 1999 Journal Neuroscience Section Abstract Doc Link 10465460 Disease Relevance 0.61 Pain Relevance 0.61
Aspirin causes rapid up-regulation of cyclo-oxygenase-2 expression in the stomach of rats.
Positive_regulation (causes) of Gene_expression (expression) of cyclo-oxygenase-2 in stomach associated with aspirin
5) Confidence 0.12 Published 1997 Journal Aliment. Pharmacol. Ther. Section Title Doc Link 9663836 Disease Relevance 0.18 Pain Relevance 0.28
An observation that might favour of NSAIDs consumption as a factor promoting sensitization is that NSAIDs increase spinal expression of inducible cyclo-oxygenase-2 [29], an enzyme that contributes to sensitization in a rat model of inflammatory pain [30].
Positive_regulation (increase) of Gene_expression (expression) of cyclo-oxygenase-2 in spinal associated with ipn and cinod
6) Confidence 0.11 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3024248 Disease Relevance 1.15 Pain Relevance 1.87
An observation that might favour of NSAIDs consumption as a factor promoting sensitization is that NSAIDs increase spinal expression of inducible cyclo-oxygenase-2 [29], an enzyme that contributes to sensitization in a rat model of inflammatory pain [30].
Positive_regulation (increase) of Gene_expression (expression) of cyclo-oxygenase-2 in spinal associated with ipn and cinod
7) Confidence 0.08 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3024248 Disease Relevance 1.15 Pain Relevance 1.87
H. pylori infection induced cyclo-oxygenase-2 expression in the stomach.
Positive_regulation (induced) of Gene_expression (expression) of cyclo-oxygenase-2 in stomach
8) Confidence 0.05 Published 2002 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 11929405 Disease Relevance 0.26 Pain Relevance 0
Increased expression of cyclo-oxygenase 2 and vascular endothelial growth factor in lesioned spinal cord by transplanted olfactory ensheathing cells.
Positive_regulation (Increased) of Gene_expression (expression) of cyclo-oxygenase 2 in spinal cord associated with cox2 and spinal cord
9) Confidence 0.03 Published 2004 Journal J. Neurotrauma Section Title Doc Link 15319002 Disease Relevance 0.18 Pain Relevance 0.34
Main target of NSAIDs seems to be the inhibition of cyclo-oxygenase-2 (COX-2), which is overexpressed in several epithelial tumours and catalyses the synthesis of prostaglandins.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of cyclo-oxygenase-2 associated with cancer and cinod
10) Confidence 0.01 Published 2007 Journal Br. J. Dermatol. Section Abstract Doc Link 17488403 Disease Relevance 0.90 Pain Relevance 0.77
Carrageenan-induced hyperalgesia is associated with increased cyclo-oxygenase-2 expression in spinal cord.
Positive_regulation (increased) of Gene_expression (expression) of cyclo-oxygenase-2 in spinal cord associated with hyperalgesia, cox2 and spinal cord
11) Confidence 0.01 Published 1997 Journal Neuroreport Section Title Doc Link 9175123 Disease Relevance 0.59 Pain Relevance 0.59
PGE(2) production in endometriosis is up-regulated by increased levels of the enzyme cyclo-oxygenase-2 (COX-2) in this tissue.
Positive_regulation (increased) of Gene_expression (levels) of cyclo-oxygenase-2 associated with endometriosis
12) Confidence 0.00 Published 2006 Journal Hum. Reprod. Update Section Abstract Doc Link 16123052 Disease Relevance 1.00 Pain Relevance 0.42
PGE(2) production in endometriosis is up-regulated by increased levels of the enzyme cyclo-oxygenase-2 (COX-2) in this tissue.
Positive_regulation (up-regulated) of Gene_expression (levels) of cyclo-oxygenase-2 associated with endometriosis
13) Confidence 0.00 Published 2006 Journal Hum. Reprod. Update Section Abstract Doc Link 16123052 Disease Relevance 1.00 Pain Relevance 0.42

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