INT69743

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Context Info
Confidence 0.78
First Reported 1997
Last Reported 2010
Negated 0
Speculated 3
Reported most in Abstract
Documents 36
Total Number 39
Disease Relevance 20.77
Pain Relevance 14.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Hmox2) endoplasmic reticulum (Hmox2) plasma membrane (Hmox2)
Anatomy Link Frequency
epithelium 8
spinal cord 5
oesophagus 2
stomach 2
spinal nerve 1
Hmox2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 47 100.00 Very High Very High Very High
COX2 32 100.00 Very High Very High Very High
Spinal cord 34 99.84 Very High Very High Very High
cINOD 91 99.66 Very High Very High Very High
endometriosis 7 99.40 Very High Very High Very High
Hyperalgesia 3 99.40 Very High Very High Very High
aspirin 10 99.38 Very High Very High Very High
Arthritis 11 99.30 Very High Very High Very High
Lasting pain 1 98.56 Very High Very High Very High
cytokine 7 98.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 77 100.00 Very High Very High Very High
Apoptosis 28 99.92 Very High Very High Very High
Disease 23 99.80 Very High Very High Very High
Colon Cancer 13 99.62 Very High Very High Very High
Necrosis 4 99.56 Very High Very High Very High
Brain Disease 1 99.56 Very High Very High Very High
Metaplasia 20 99.42 Very High Very High Very High
Endometriosis 9 99.40 Very High Very High Very High
Hyperalgesia 3 99.40 Very High Very High Very High
Cancer 11 99.38 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ligation of spinal nerves in rats resulted in an upregulation of HO-2 expression which was most pronounced in the ipsilateral gray matter of the spinal cord compared to the contralateral side.
Gene_expression (expression) of HO-2 in gray matter associated with spinal cord
1) Confidence 0.78 Published 2000 Journal Amino Acids Section Abstract Doc Link 11026508 Disease Relevance 0.09 Pain Relevance 0.33
The influence of carbon monoxide (CO) on chronic spinal nerve lesion induced spinal cord neurodegeneration was examined using immunohistochemical expression of the constitutive isoform of its synthesising enzyme, hemeoxygenase-2 (HO-2) in a rat model.
Spec (examined) Gene_expression (expression) of HO-2 in spinal nerve associated with spinal cord
2) Confidence 0.78 Published 2000 Journal Amino Acids Section Abstract Doc Link 11026508 Disease Relevance 0.09 Pain Relevance 0.26
Sham operated rats did not show an upregulation of HO-2 expression and the structural changes in the spinal cord were absent.
Gene_expression (expression) of HO-2 in spinal cord associated with spinal cord
3) Confidence 0.78 Published 2000 Journal Amino Acids Section Abstract Doc Link 11026508 Disease Relevance 0.08 Pain Relevance 0.33
In addition, it is proposed that the increased expression of the cyclo-oxygenase 2 enzyme is central to the predisposition to both oesophageal and colon cancers.
Gene_expression (expression) of cyclo-oxygenase 2 enzyme in colon associated with colon cancer
4) Confidence 0.69 Published 1998 Journal Eur. J. Cancer Prev. Section Abstract Doc Link 9696927 Disease Relevance 1.09 Pain Relevance 0.26
Barrett's oesophagus with predominant intestinal metaplasia correlates with superficial cyclo-oxygenase-2 expression, increased proliferation and reduced apoptosis: changes that are partially reversed by non-steroidal anti-inflammatory drugs usage.
Gene_expression (expression) of cyclo-oxygenase-2 in oesophagus associated with inflammation, metaplasia, cinod, cox2 and apoptosis
5) Confidence 0.69 Published 2004 Journal Aliment. Pharmacol. Ther. Section Title Doc Link 15379840 Disease Relevance 0.29 Pain Relevance 0.15
BACKGROUND: Cyclo-oxygenase-2 expression has been reported to play an important role in the metaplasia-dysplasia-carcinoma sequence in Barrett's oesophagus.
Gene_expression (expression) of Cyclo-oxygenase-2 in oesophagus associated with cleidocranial dysplasia, metaplasia and carcinoma
6) Confidence 0.69 Published 2004 Journal Aliment. Pharmacol. Ther. Section Abstract Doc Link 15379840 Disease Relevance 0.52 Pain Relevance 0.07
AIM: To identify the cells that express cyclo-oxygenase-2 protein and to investigate the relationship between cyclo-oxygenase-2 expression and mucin-phenotype of Barrett's epithelium.
Gene_expression (express) of cyclo-oxygenase-2 in epithelium
7) Confidence 0.69 Published 2004 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 15379840 Disease Relevance 0.28 Pain Relevance 0
A significant elevation of proliferating cell nuclear antigen index and suppression of apoptotic index was observed in Barrett's epithelium with superficial epithelial cyclo-oxygenase-2 expression.
Gene_expression (expression) of cyclo-oxygenase-2 in epithelium
8) Confidence 0.69 Published 2004 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 15379840 Disease Relevance 0.17 Pain Relevance 0
However, the existence of cyclo-oxygenase-2 expressing cells in Barrett's epithelium is still uncertain.
Gene_expression (expressing) of cyclo-oxygenase-2 in epithelium
9) Confidence 0.69 Published 2004 Journal Aliment. Pharmacol. Ther. Section Abstract Doc Link 15379840 Disease Relevance 0.23 Pain Relevance 0.07
AIM: To identify the cells that express cyclo-oxygenase-2 protein and to investigate the relationship between cyclo-oxygenase-2 expression and mucin-phenotype of Barrett's epithelium.
Gene_expression (expression) of cyclo-oxygenase-2 in epithelium
10) Confidence 0.69 Published 2004 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 15379840 Disease Relevance 0.27 Pain Relevance 0
RESULTS: Cyclo-oxygenase-2 expression was detected in 71.0% of Barrett's epithelium biopsy samples.
Gene_expression (expression) of Cyclo-oxygenase-2 in epithelium
11) Confidence 0.69 Published 2004 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 15379840 Disease Relevance 0.23 Pain Relevance 0
CONCLUSIONS: Barrett's epithelium with intestinal mucin and superficial epithelial cyclo-oxygenase-2 expression possess a higher proliferation potential, but this risk may be thwarted by non-steroidal anti-inflammatory drugs administration.


Gene_expression (expression) of cyclo-oxygenase-2 in epithelium
12) Confidence 0.69 Published 2004 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 15379840 Disease Relevance 0 Pain Relevance 0
METHODS: Sections from 466 biopsy samples of Barrett's epithelium from 358 non-medicated patients were immunohistochemically examined for the cyclo-oxygenase-2 expression, mucin-phenotype, cell proliferation and apoptosis.
Spec (examined) Gene_expression (expression) of cyclo-oxygenase-2 in epithelium
13) Confidence 0.69 Published 2004 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 15379840 Disease Relevance 0.24 Pain Relevance 0
In Barrett's epithelium with the gastric predominant mucin-phenotype, cyclo-oxygenase-2 expression was mainly found in stromal and deep epithelial cells, whereas in intestinal predominant mucin-phenotype, it was mostly in superficial epithelial cell.
Gene_expression (expression) of cyclo-oxygenase-2 in epithelial cells
14) Confidence 0.69 Published 2004 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 15379840 Disease Relevance 0.21 Pain Relevance 0
We also examined cyclo-oxygenase-1 and cyclo-oxygenase-2 protein levels in the spinal cord during the development of inflammation using the same model of arthritis.
Spec (examined) Gene_expression (levels) of cyclo-oxygenase-2 in spinal cord associated with inflammation, arthritis and spinal cord
15) Confidence 0.48 Published 1999 Journal Neuroscience Section Abstract Doc Link 10465460 Disease Relevance 0.44 Pain Relevance 0.31
The results show that there is a tonic release of immunoreactive prostaglandin E2 from the spinal cord following the induction of arthritis, which is accompanied by enhanced expression of cyclo-oxygenase-2 protein in the spinal cord.
Gene_expression (expression) of cyclo-oxygenase-2 in spinal cord associated with arthritis and spinal cord
16) Confidence 0.48 Published 1999 Journal Neuroscience Section Abstract Doc Link 10465460 Disease Relevance 0.61 Pain Relevance 0.60
Aspirin causes rapid up-regulation of cyclo-oxygenase-2 expression in the stomach of rats.
Gene_expression (expression) of cyclo-oxygenase-2 in stomach associated with aspirin
17) Confidence 0.14 Published 1997 Journal Aliment. Pharmacol. Ther. Section Title Doc Link 9663836 Disease Relevance 0.18 Pain Relevance 0.28
An observation that might favour of NSAIDs consumption as a factor promoting sensitization is that NSAIDs increase spinal expression of inducible cyclo-oxygenase-2 [29], an enzyme that contributes to sensitization in a rat model of inflammatory pain [30].
Gene_expression (expression) of cyclo-oxygenase-2 in spinal associated with ipn and cinod
18) Confidence 0.12 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3024248 Disease Relevance 1.09 Pain Relevance 1.81
Cyclo-oxygenase-2 may be expressed constitutively, whereas the generation of prostaglandin by cyclo-oxygenase-2 may replace that by cyclo-oxygenase-1 in some situations (or vice-versa).
Gene_expression (expressed) of Cyclo-oxygenase-2
19) Confidence 0.10 Published 2001 Journal Dig Liver Dis Section Abstract Doc Link 11827358 Disease Relevance 0.24 Pain Relevance 0.27
Although cyclo-oxygenase-1 seems to be expressed in physiological conditions and cyclo-oxygenase-2 in inflammatory conditions, it is not yet possible to identify all their different roles.
Gene_expression (expressed) of cyclo-oxygenase-2 associated with inflammation
20) Confidence 0.10 Published 2001 Journal Dig Liver Dis Section Abstract Doc Link 11827358 Disease Relevance 0.25 Pain Relevance 0.28

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