INT69749

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Context Info
Confidence 0.06
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.20
Pain Relevance 0.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tacr3) plasma membrane (Tacr3) nucleus (Tacr3)
signal transducer activity (Tacr3)
Anatomy Link Frequency
afferent neurons 1
Tacr3 (Mus musculus)
Pain Link Frequency Relevance Heat
pruritus 71 99.68 Very High Very High Very High
substance P 80 99.20 Very High Very High Very High
antagonist 14 98.20 Very High Very High Very High
Antihistamine 4 93.48 High High
cytokine 21 87.08 High High
chemokine 1 53.52 Quite High
Inflammation 16 48.72 Quite Low
Pain 14 30.56 Quite Low
agonist 1 25.00 Low Low
Central nervous system 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pruritus 82 99.68 Very High Very High Very High
Granuloma 92 96.72 Very High Very High Very High
Targeted Disruption 42 94.20 High High
Skin Diseases 3 90.28 High High
Cyst 12 85.24 High High
Mycobacterial Infection 1 59.32 Quite High
Infection 13 50.00 Quite Low
INFLAMMATION 13 48.72 Quite Low
Dermatological Disease 3 48.40 Quite Low
Disease Susceptibility 7 45.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As it binds to the neurokinin receptor 1 (NKR1), we evaluated if the application of a NKR1 antagonist would significantly decrease chronic pruritus.


NKR1 Binding (binds) of associated with antagonist and pruritus
1) Confidence 0.06 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2881044 Disease Relevance 0.68 Pain Relevance 0.50
may occur through binding of SP to other members of the NK family, for example, NK2 or NK3.

3.4.

NK3 Binding (example) of associated with substance p
2) Confidence 0.02 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2817809 Disease Relevance 1.51 Pain Relevance 0.25
When released from intrinsic enteric or extrinsic primary afferent neurons, tachykinins have the potential to influence both nerve and muscle by way of interaction with three different types of tachykinin receptor, termed NK1, NK2 and NK3 receptors.
NK3 Binding (interaction) of in afferent neurons
3) Confidence 0.00 Published 1997 Journal Pharmacol. Ther. Section Abstract Doc Link 9175155 Disease Relevance 0 Pain Relevance 0.07

General Comments

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