INT69764

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Context Info
Confidence 0.70
First Reported 1997
Last Reported 2010
Negated 0
Speculated 10
Reported most in Abstract
Documents 126
Total Number 136
Disease Relevance 67.80
Pain Relevance 91.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Cnr1) plasma membrane (Cnr1) response to stress (Cnr1)
signal transducer activity (Cnr1)
Anatomy Link Frequency
spinal 5
primary sensory neurons 4
body 3
brain 3
neuronal 3
Cnr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cannabinoid 983 100.00 Very High Very High Very High
Pain 536 100.00 Very High Very High Very High
Cannabinoid receptor 362 100.00 Very High Very High Very High
Inflammation 343 100.00 Very High Very High Very High
Analgesic 191 100.00 Very High Very High Very High
Antinociceptive 137 100.00 Very High Very High Very High
Ventral tegmentum 126 100.00 Very High Very High Very High
Glutamate receptor 14 100.00 Very High Very High Very High
opioid receptor 9 100.00 Very High Very High Very High
Endocannabinoid 661 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Anxiety Disorder 468 100.00 Very High Very High Very High
INFLAMMATION 344 99.98 Very High Very High Very High
Nervous System Injury 151 99.98 Very High Very High Very High
Pain 605 99.92 Very High Very High Very High
Inflammatory Pain 53 99.90 Very High Very High Very High
Obesity 534 99.84 Very High Very High Very High
Weight Loss 49 99.84 Very High Very High Very High
Status Epilepticus 114 99.82 Very High Very High Very High
Hypothermia 25 99.72 Very High Very High Very High
Nociception 274 99.70 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, VUF5420 showed very low affinity (Kd approximately 10 microM) on CB1-receptor activation of 35S-GTPgammaS binding, indicating that this drug does not directly interact with the CB1 receptor in vivo.
Positive_regulation (activation) of CB1
1) Confidence 0.70 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16806300 Disease Relevance 0.08 Pain Relevance 1.44
Pharmacological activation of CB1 and D2 receptors in rats: predominant role of CB1 in the increase of alcohol relapse.
Positive_regulation (activation) of CB1 associated with analgesic, recurrence and alcohol
2) Confidence 0.70 Published 2008 Journal Eur. J. Neurosci. Section Title Doc Link 18554293 Disease Relevance 0.71 Pain Relevance 0.68
We found that subchronic activation of CB1 (WIN 55,212-2, 2 mg/kg), but not D2 receptors (quinpirole, 1 mg/kg), during a period of alcohol deprivation increased long-lasting alcohol relapse.
Positive_regulation (activation) of CB1 associated with recurrence and alcohol
3) Confidence 0.70 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18554293 Disease Relevance 0.75 Pain Relevance 0.64
Together, these results essentially demonstrate that activation of CB1 receptors plays a key role in the increase of alcohol relapse, whereas inactivation of D2 receptors modulates this aberrant behavior.
Positive_regulation (activation) of CB1 associated with recurrence and alcohol
4) Confidence 0.70 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18554293 Disease Relevance 0.69 Pain Relevance 0.66
The early alterations in abdominal contractile response to colorectal distension of agonist/antagonist treated rats and the increased levels of CB1R mRNA in myenteric plexuses of enhanced sensation colons seem to point to an important, if not predominant, function of the endogenous cannabinoid system at peripheral sites.
Positive_regulation (increased) of CB1R mRNA in colons associated with cannabinoid, antagonist and agonist
5) Confidence 0.70 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2912121 Disease Relevance 0.70 Pain Relevance 0.82
These findings provide ultrastructural evidence that cannabinoid-opioid interactions are mediated by activation of CB1 and mu-opioid receptors within the same or synaptically linked neurons in the Acb shell and core.
Positive_regulation (activation) of CB1 in neurons associated with nucleus accumbens, cannabinoid, mu opioid receptor and opioid
6) Confidence 0.70 Published 2004 Journal Neuroscience Section Abstract Doc Link 15219673 Disease Relevance 0 Pain Relevance 0.67
BACKGROUND: Anandamide (AEA), one of the endocannabinoid compounds, has an important regulatory function by serving as an autocrine/paracrine or endocrine factor throughout the body via activation of the cannabinoid receptor 1 (CB1) and/or the transient receptor potential vanilloid type 1 (TRPV1) channels.
Positive_regulation (activation) of cannabinoid receptor 1 in body associated with endocannabinoid and cannabinoid receptor
7) Confidence 0.68 Published 2006 Journal J. Hypertens. Section Abstract Doc Link 17053550 Disease Relevance 0 Pain Relevance 0.10
BACKGROUND: Anandamide (AEA), one of the endocannabinoid compounds, has an important regulatory function by serving as an autocrine/paracrine or endocrine factor throughout the body via activation of the cannabinoid receptor 1 (CB1) and/or the transient receptor potential vanilloid type 1 (TRPV1) channels.
Positive_regulation (activation) of CB1 in body associated with endocannabinoid and cannabinoid receptor
8) Confidence 0.68 Published 2006 Journal J. Hypertens. Section Abstract Doc Link 17053550 Disease Relevance 0 Pain Relevance 0.10
While activation of the CB1 receptor may underlie AEA-induced depressor effects, the diuretic effect of AEA appears to be mediated by neuronal reflex of the kidney, which is not sensitive to blockade of the TRPV1 or CB1 receptor.


Positive_regulation (activation) of CB1 receptor in kidney
9) Confidence 0.68 Published 2006 Journal J. Hypertens. Section Body Doc Link 17053550 Disease Relevance 0 Pain Relevance 0
It is well known that the endocannabinoid/CB1 tone is upregulated in obesity, at both the central and peripheral levels (27–31).
Positive_regulation (upregulated) of CB1 associated with endocannabinoid and obesity
10) Confidence 0.68 Published 2008 Journal Diabetes Section Body Doc Link PMC2570394 Disease Relevance 0.54 Pain Relevance 0.27
Here we investigated whether presynaptic inhibition can be caused by activation of postsynaptic group I metabotropic glutamate receptors (mGluRs) and following presynaptic cannabinoid receptor type 1 (CB1 receptor) using mechanically dissociated rat hippocampal CA3 pyramidal neurons with adherent functional synaptic boutons.
Positive_regulation (activation) of CB1 receptor in boutons associated with cannabinoid receptor, pyramidal cell and glutamate receptor
11) Confidence 0.67 Published 2010 Journal Neuroscience Section Abstract Doc Link 19961906 Disease Relevance 0 Pain Relevance 0.81
In summary, our data indicate a major role for VR1 receptors, as compared to CB1 receptors, in the antihyperkinetic effects and the recovery of neurochemical deficits caused in 3NP-lesioned rats by compounds that activate both CB1 and VR1 receptors, either directly or via manipulation of the levels of endogenous agonists.
Positive_regulation (activate) of CB1 associated with agonist
12) Confidence 0.67 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12603833 Disease Relevance 0.29 Pain Relevance 0.55
Hypotensive effect of anandamide through the activation of CB1 and VR1 spinal receptors in urethane-anesthetized rats.
Positive_regulation (activation) of CB1 in spinal associated with qutenza
13) Confidence 0.67 Published 2003 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Title Doc Link 14504685 Disease Relevance 0.36 Pain Relevance 0.64
In contrast to classical neurotransmitters, endogenous cannabinoids can function as retrograde synaptic messengers: They are released from postsynaptic neurons and travel backward across synapses, activating CB1 on presynaptic axons and suppressing neurotransmitter release.
Positive_regulation (activating) of CB1 in synapses associated with neurotransmitter and cannabinoid
14) Confidence 0.66 Published 2002 Journal Science Section Abstract Doc Link 11976437 Disease Relevance 0.18 Pain Relevance 0.36
In summary, the unilateral 6-hydroxydopamine lesion of nigrostriatal dopaminergic neurons originated a marked increase in CB1 receptor-mRNA levels in cell bodies of striatal efferent neurons, although accompanied by no changes in CB1 receptor binding and activation of signal transduction mechanisms.
Positive_regulation (increase) of CB1 in dopaminergic neurons
15) Confidence 0.66 Published 2000 Journal Life Sci. Section Abstract Doc Link 10794065 Disease Relevance 0 Pain Relevance 0.11
Unilateral 6-hydroxydopamine lesions of nigrostriatal dopaminergic neurons increased CB1 receptor mRNA levels in the caudate-putamen.
Positive_regulation (increased) of CB1 in caudate-putamen associated with enkephalin
16) Confidence 0.66 Published 2000 Journal Life Sci. Section Title Doc Link 10794065 Disease Relevance 0 Pain Relevance 0.25
Activation of CB1 and CB2 receptors attenuates the induction and maintenance of inflammatory pain in the rat.
Positive_regulation (Activation) of CB1 associated with analgesic and ipn
17) Confidence 0.65 Published 2005 Journal Pain Section Title Doc Link 16289798 Disease Relevance 0.53 Pain Relevance 1.12
Low levels of AEA in the receptive uterus and activated CB1 in blastocysts are beneficial for implantation, whereas higher AEA levels are detrimental to this process [20-22].
Positive_regulation (activated) of CB1 in uterus
18) Confidence 0.64 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2775033 Disease Relevance 0.08 Pain Relevance 0.16
Our western blot results showed that CB1 was upregulated during midpregnancy, being ~1.5-fold higher on day 12, which is not in accordance with Q-PCR data, suggesting that the expression of proteins is transcription-unregulated.
Positive_regulation (upregulated) of CB1
19) Confidence 0.64 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2775033 Disease Relevance 0 Pain Relevance 0.04
URB597 dose dependently enhanced PAG anandamide and 2-AG levels, with probable subsequent activation of TRPV1/CB1 receptors and only CB1 receptors, respectively.
Spec (probable) Positive_regulation (activation) of CB1 associated with central grey
20) Confidence 0.64 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16284279 Disease Relevance 0.98 Pain Relevance 0.95

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