INT69768

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Context Info
Confidence 0.51
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 4.76
Pain Relevance 2.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
photoreceptor 1
monocytes 1
PSCs 1
NK cell 1
DRN 1
Pscs (Mus musculus)
Pain Link Frequency Relevance Heat
Action potential 3 100.00 Very High Very High Very High
tetrodotoxin 2 100.00 Very High Very High Very High
Enkephalin 8 99.92 Very High Very High Very High
fibrosis 12 99.90 Very High Very High Very High
Central grey 1 99.12 Very High Very High Very High
Pyramidal cell 6 95.48 Very High Very High Very High
GABAergic 3 94.40 High High
antagonist 1 88.08 High High
agonist 3 86.44 High High
cytokine 24 86.20 High High
Disease Link Frequency Relevance Heat
Retinal Diseases 22 99.96 Very High Very High Very High
Fibrosis 12 99.90 Very High Very High Very High
Disease 114 99.20 Very High Very High Very High
Urological Neuroanatomy 2 99.12 Very High Very High Very High
Retina Disease 34 98.28 Very High Very High Very High
Cancer 83 92.52 High High
INFLAMMATION 21 85.76 High High
Cleidocranial Dysplasia 2 83.20 Quite High
Pancreatic Cancer 17 82.56 Quite High
Pancreatic Ductal Carcinoma 1 79.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This reduction in both presynaptic and postsynaptic elements was paralleled by a significant decrease in frequency of tetrodotoxin-insensitive miniature (action potential-independent) PSCs (mPSCs).
Negative_regulation (decrease) of PSCs associated with action potential and tetrodotoxin
1) Confidence 0.51 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 11069968 Disease Relevance 0.06 Pain Relevance 0.55
These results suggest that CM attenuated DBTC-induced rat pancreatic fibrosis via inhibition of monocytes and PSCs activity.
Negative_regulation (inhibition) of PSCs in PSCs associated with fibrosis
2) Confidence 0.15 Published 2005 Journal Lab. Invest. Section Abstract Doc Link 15531908 Disease Relevance 0.67 Pain Relevance 0.30
Consistent with the reduction in PSCs, ENK inhibited/hyperpolarized the great majority (81%) of non-serotonergic neurons recorded extra- and intracellularly in the DRN; the ENK effect reversed polarity at -99 +/- 9 mV, close to the potassium reversal potential.
Negative_regulation (reduction) of PSCs in DRN associated with enkephalin
3) Confidence 0.10 Published 1997 Journal Brain Res. Section Abstract Doc Link 9175891 Disease Relevance 0.10 Pain Relevance 1.35
In addition, the transformation of freshly isolated PSCs from quiescent to myofibroblast-like phenotyp in culture was also blocked by ellagic acid.
Negative_regulation (blocked) of PSCs
4) Confidence 0.07 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872306 Disease Relevance 0.58 Pain Relevance 0.20
These results suggest that CM attenuated DBTC-induced rat pancreatic fibrosis via inhibition of monocytes and PSCs activity.
Negative_regulation (inhibition) of PSCs in monocytes associated with fibrosis
5) Confidence 0.05 Published 2005 Journal Lab. Invest. Section Abstract Doc Link 15531908 Disease Relevance 0.67 Pain Relevance 0.30
Of equal importance is the derivation of iPSCs from patients with retinal disease for creation of disease models, which provides an invaluable opportunity to investigate disease pathogenesis and treatment that has not been possible before.
Negative_regulation (derivation) of iPSCs associated with disease and retinal diseases
6) Confidence 0.00 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2962903 Disease Relevance 0.85 Pain Relevance 0
Derivation of iPSCs from patients with diseases causing outer retinal degeneration, alongside in vitro gene correction with a robust differentiation method for producing photoreceptor and RPE cells from these cells, could provide a source of autologous cells for transplantation.
Negative_regulation (Derivation) of iPSCs in photoreceptor associated with disease and retina disease
7) Confidence 0.00 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2962903 Disease Relevance 1.25 Pain Relevance 0.03
In addition, both hESCs and iPSCs as well as a number of other stem cells such as hMSCs and hDPSCs were found to be significantly more susceptible to NK cell mediated cytotoxicity.
Negative_regulation (number) of iPSCs in NK cell
8) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905395 Disease Relevance 0.58 Pain Relevance 0.09

General Comments

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