INT69771

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Context Info
Confidence 0.52
First Reported 1997
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 0.31
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Kcnma1) endoplasmic reticulum (Kcnma1) plasma membrane (Kcnma1)
transmembrane transport (Kcnma1)
Anatomy Link Frequency
cardiomyocytes 1
muscle 1
Kcnma1 (Mus musculus)
Pain Link Frequency Relevance Heat
potassium channel 41 100.00 Very High Very High Very High
depression 58 98.52 Very High Very High Very High
member 8 1 97.84 Very High Very High Very High
antagonist 7 68.12 Quite High
tetrodotoxin 1 64.20 Quite High
agonist 3 21.44 Low Low
anesthesia 5 5.00 Very Low Very Low Very Low
addiction 3 5.00 Very Low Very Low Very Low
Somatostatin 3 5.00 Very Low Very Low Very Low
Action potential 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 58 98.52 Very High Very High Very High
Ataxia 21 76.56 Quite High
Camurati-engelmann Disease 4 5.00 Very Low Very Low Very Low
Stress 3 5.00 Very Low Very Low Very Low
Congenital Anomalies 2 5.00 Very Low Very Low Very Low
Infection 2 5.00 Very Low Very Low Very Low
Dysmenorrhea 1 5.00 Very Low Very Low Very Low
Breech Presentation 1 5.00 Very Low Very Low Very Low
Placenta Previa 1 5.00 Very Low Very Low Very Low
Shock 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Maximal activation of BK channels (alias maxiK, KCNMA1, KCa1.1 or slowpoke) requires both membrane depolarization and increased intracellular Ca2+[4], [5].
Positive_regulation (activation) of KCNMA1
1) Confidence 0.52 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2776494 Disease Relevance 0.08 Pain Relevance 0
Cumulative additions of THG113.31 resulted in a potent activation of BKCa channel activity in a concentration-dependent fashion, as illustrated (Figure 2B &2C).
Positive_regulation (activation) of BKCa associated with potassium channel
2) Confidence 0.49 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1831777 Disease Relevance 0 Pain Relevance 0.37
The amino acid sequence demonstrated that mCardBKa was a unique BK(Ca) channel alpha-subunit in mouse cardiomyocytes, with amino acids 41-1153 being identical to calcium-activated potassium channel SLO1 and amino acids 1-40 corresponding to BK(Ca) channel subfamily M alpha member 1.
Positive_regulation (activated) of SLO1 in cardiomyocytes associated with member 8 and potassium channel
3) Confidence 0.42 Published 2009 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 19699717 Disease Relevance 0 Pain Relevance 0.15
Since mutation of the caveolin-binding site had a significant effect on activation of the maxi-K channel, we next determined the role of the caveolin-binding motif in regulating localization of the maxi-K channel within lipid rafts.
Positive_regulation (activation) of maxi-K channel
4) Confidence 0.24 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2785819 Disease Relevance 0 Pain Relevance 0
For example, components crucial for the regulation of Ca2+, a key regulator of the maxi-K channel, are localized in caveolae and may serve as initiation sites for Ca2+ release events, including Ca2+ sparks [21,22].
Positive_regulation (regulator) of maxi-K channel
5) Confidence 0.16 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2785819 Disease Relevance 0 Pain Relevance 0
In the experiments, the activation of KCa channels could not only be observed as an AHP in super-threshold responses (FigureĀ 3F) but was also reflected by the faster initial decay of larger EPSPs (Figures 3B and 3G).
Positive_regulation (activation) of KCa
6) Confidence 0.02 Published 2007 Journal Neuron Section Body Doc Link PMC1885969 Disease Relevance 0.23 Pain Relevance 0.12
The results suggest that the large-conductance Kca channel is constitutively activated for modulations of spontaneous activity, and that muscle excitation, through elevation of Ca2+ levels, stimulates the large-conductance Kca channel to suppress spontaneous activity.
Positive_regulation (stimulates) of Kca in muscle
7) Confidence 0.01 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9176202 Disease Relevance 0 Pain Relevance 0.10

General Comments

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