INT69775

Context Info Confidence 0.05 First Reported 1996 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.77 Pain Relevance 0.71

Anatomy Link Frequency liver 1 cy (Mus musculus)

Pain Link Frequency Relevance Heat imagery 43 99.32 Paracetamol 5 88.24 Inflammation 5 5.00 isoflurane 2 5.00 anesthesia 1 5.00

Disease Link Frequency Relevance Heat Coronary Artery Disease 1 90.40 Bladder Cancer 32 77.52 Targeted Disruption 13 76.08 Hepatotoxicity 2 75.00 Cataract 1 72.44 Disease 1 51.68 Cancer 49 5.00 Metastasis 6 5.00 INFLAMMATION 5 5.00 Transitional Cell Carcinoma 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

This enabled comparisons to be made of the efficacy of L-CySSME as well as Ac-CySSME and Et-CySSME with other representative prodrugs of L-cysteine, namely, 2(RS)-methylthiazolidine-4(R)-carboxylic acid (MTCA), L-2-oxothiazolidine-4-carboxylic acid (OTCA), and N-acetyl-L-cysteine (NAC), in protecting the liver.

Gene_expression (made) of L-CySSME in liver

1) Confidence 0.05 Published 1996 Journal J. Biochem. Toxicol. Section Abstract Doc Link 9176740 Disease Relevance 0.21 Pain Relevance 0.37

MRS conceived study and experimental design, participated in NIRF experiments, performed IHC analysis, interpreted the results, and drafted the manuscript; RT performed MRI experiments, participated on the design, results interpretation, and helped drafting the manuscript; NS synthesized the d-Cy5.5; AA performed MRI experiments and interpretation of MRI results; MN consulted MRS regarding the proper contrast agents, participated in the design of MRI experiments and interpretation of the results, and helped drafting the manuscript; CAD maintained the genotyping and animal colony, and performed image analysis; CS performed animal experiments and whole mount IHC; JM participated on the design of immunohistochemistry protocols and choice of antibodies, performed the immunohistochemistry and confocal microscopy analysis; SM developed kB-lacZ mice, participate in the design of the double transgenic, and helped drafting the manuscript; X-RW developed UPKII-SV40T mice, participate in the design of the double transgenic, and helped drafting the manuscript; and RS participated in the experimental design, performed NIRF experiments and data interpretation.

Gene_expression (synthesized) of Cy5 associated with targeted disruption, coronary artery disease and imagery

2) Confidence 0.01 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2241841 Disease Relevance 0.55 Pain Relevance 0.34

General Comments

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