INT69781

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Context Info
Confidence 0.42
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 22
Total Number 22
Disease Relevance 17.25
Pain Relevance 4.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (FGF2) extracellular space (FGF2) extracellular region (FGF2)
nucleus (FGF2) cytoplasm (FGF2)
Anatomy Link Frequency
fibroblast 6
striatum 1
Eosinophils 1
endometrium 1
hippocampus 1
FGF2 (Homo sapiens)
Pain Link Frequency Relevance Heat
bDMF 12 99.84 Very High Very High Very High
Dismenorea 3 99.48 Very High Very High Very High
ischemia 17 99.30 Very High Very High Very High
sSRI 9 98.98 Very High Very High Very High
depression 69 98.96 Very High Very High Very High
COX-2 inhibitor 6 98.88 Very High Very High Very High
antidepressant 12 98.56 Very High Very High Very High
cINOD 2 98.44 Very High Very High Very High
Hippocampus 9 98.32 Very High Very High Very High
Dopamine 113 96.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pituitary Cancer 26 100.00 Very High Very High Very High
Eosinophilic Esophagitis 318 99.48 Very High Very High Very High
Dysmenorrhea 3 99.48 Very High Very High Very High
Proteinuria 20 99.36 Very High Very High Very High
Diabetes Mellitus 33 99.32 Very High Very High Very High
Coronary Artery Disease 77 99.30 Very High Very High Very High
Depression 84 98.96 Very High Very High Very High
Cancer 304 98.24 Very High Very High Very High
Glaucoma 3 97.84 Very High Very High Very High
INFLAMMATION 26 97.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The study was stopped prematurely after treatment of the first 24 subjects due to proteinuria in five of the 16 subjects who received systemic bFGF, which exceeded 1000 mg/24 h in four of these five subjects.
Negative_regulation (received) of bFGF associated with proteinuria
1) Confidence 0.42 Published 2001 Journal Vasc Med Section Abstract Doc Link 11958389 Disease Relevance 0.82 Pain Relevance 0.24
This study was designed to evaluate if adenomyosis expresses bFGF and FGF-R, and if present, to compare bFGF and FGF-R expression in adenomyosis and autologous endometrium.
Negative_regulation (compare) of bFGF in endometrium associated with dismenorea
2) Confidence 0.41 Published 2001 Journal Menopause Section Abstract Doc Link 11528364 Disease Relevance 0.46 Pain Relevance 0.27
Computational analysis predicted fibroblast growth factor-2 (FGF-2) as the strongest target gene for hsa-miR15b.
Negative_regulation (predicted) of FGF-2 in fibroblast
3) Confidence 0.41 Published 2010 Journal J. Cell. Biochem. Section Abstract Doc Link 20564181 Disease Relevance 0.84 Pain Relevance 0.74
A history of antidepressant treatment with SSRIs in the depressed subjects seemed to mitigate this decrease in FGFs and FGF receptors, especially for FGF2, FGFR2 and FGFR3.
Negative_regulation (decrease) of FGF2 associated with antidepressant and ssri
4) Confidence 0.40 Published 2005 Journal Genome Biol Section Body Doc Link PMC1088952 Disease Relevance 1.06 Pain Relevance 0.84
Moreover, recent work in rats has shown that a combination of the SSRI antidepressant fluoxetine and the atypical antipsychotic drug olanzapine, which appear in human studies to be more effective for the treatment of resistant depression in combination than individually, led to increased levels of FGF2 mRNA in prefrontal cortex, as well as in hippocampus and striatum [8].
Negative_regulation (levels) of FGF2 in hippocampus associated with antidepressant, depression, hippocampus, ssri and fluoxetine
5) Confidence 0.40 Published 2005 Journal Genome Biol Section Body Doc Link PMC1088952 Disease Relevance 0.87 Pain Relevance 0.59
A factor related to the diabetic condition (unbalanced glucose levels, defective insulin regulation, etc) in cooperation with the myocardial ischemia could be responsible for the high levels of VEGF and bFGF observed in the diabetic patients (CAD SA).
Negative_regulation (levels) of bFGF associated with coronary artery disease, diabetes mellitus and ischemia
6) Confidence 0.37 Published 2003 Journal J Transl Med Section Body Doc Link PMC239962 Disease Relevance 1.57 Pain Relevance 0.22
Pharmacological evaluation showed that basic fibroblast growth factory and transforming growth factor beta decreased the GC induction of TIGR, and certain nonsteroidal anti-inflammatory drugs protected against both GC- and oxidation-induced stress responses in HTM cells.
Negative_regulation (decreased) of basic fibroblast growth factory and transforming growth factor beta in fibroblast associated with stress, inflammation and cinod
7) Confidence 0.34 Published 1997 Journal Ophthalmologica Section Abstract Doc Link 9176893 Disease Relevance 0.52 Pain Relevance 0.13
A comparison between gene expression in velvet and skin samples from pedicle and frontal showed an opposite trend, with most genes, including BDNF, BMP2, FGF2, L1-CAM, Meteorin and NR-CAM, appearing downregulated in velvet.
Negative_regulation (downregulated) of FGF2 in skin associated with bdmf
8) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004953 Disease Relevance 0 Pain Relevance 0.09
Treated EoE subjects had a statistically significant decrease in bFGF (n = 9, mean 4.60 pg/mL, s.e. 1.35 pg/mL, p < 0.05) (Figure 3a).
Negative_regulation (decrease) of bFGF associated with eosinophilic esophagitis
9) Confidence 0.28 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2976489 Disease Relevance 1.43 Pain Relevance 0.07
A decrease in bFGF was seen in all subjects.
Negative_regulation (decrease) of bFGF
10) Confidence 0.24 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2976489 Disease Relevance 1.43 Pain Relevance 0.08
In summary, we demonstrated that PO inhibited bFGF-stimulated proliferation, migration, tube formation in human endothelial cells and also disrupted in vivo neovascularization.
Negative_regulation (inhibited) of bFGF in endothelial cells
11) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2925949 Disease Relevance 0.38 Pain Relevance 0
The treatment with PO blocked bFGF-stimulated migration and in vitro capillary differentiation (tube formation) in a dose-dependent manner.
Negative_regulation (blocked) of bFGF in tube
12) Confidence 0.23 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2925949 Disease Relevance 0.33 Pain Relevance 0.03
Eosinophils are also known to secrete bFGF [23] and FGF-9 [24] upon the presence of necrotic epithelial cells. bFGF is also known to be secreted in case of cellular damage, such as the esophageal epithelial tissue damage experienced by EoE subjects [12].
Negative_regulation (secrete) of bFGF in Eosinophils associated with eosinophilic esophagitis
13) Confidence 0.23 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2976489 Disease Relevance 0.77 Pain Relevance 0
These data are in line with Hasegawa et al. [41] and Basu et al. [42] showing an inhibition of bFGF and VEGF using a selective COX-2 inhibitor.
Negative_regulation (inhibition) of bFGF associated with cox-2 inhibitor
14) Confidence 0.20 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2841144 Disease Relevance 0.41 Pain Relevance 0.08
Hsulf-1 expression significantly attenuated FGF-2 (50 ng/ml) induced cell growth by around 50%, from +28.0 ± 3.8% in controls to +14.4 ± 1.0 % in Hsulf-1 clones (Figure 6).
Negative_regulation (attenuated) of FGF-2
15) Confidence 0.15 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1087876 Disease Relevance 0.33 Pain Relevance 0
Moreover, recent work in rats has shown that a combination of the SSRI antidepressant fluoxetine and the atypical antipsychotic drug olanzapine, which appear in human studies to be more effective for the treatment of resistant depression in combination than individually, led to increased levels of FGF2 mRNA in prefrontal cortex, as well as in hippocampus and striatum [8].
Negative_regulation (levels) of FGF2 in striatum associated with antidepressant, depression, hippocampus, ssri and fluoxetine
16) Confidence 0.14 Published 2005 Journal Genome Biol Section Body Doc Link PMC1088952 Disease Relevance 0.87 Pain Relevance 0.59
Thalidomide inhibits the activity of basic fibroblast growth factor-2 (bFGF).
Negative_regulation (inhibits) of basic fibroblast growth factor-2 in fibroblast
17) Confidence 0.11 Published 2010 Journal OncoTargets and therapy Section Body Doc Link PMC2895781 Disease Relevance 1.88 Pain Relevance 0.04
Thalidomide inhibits the activity of basic fibroblast growth factor-2 (bFGF).
Negative_regulation (inhibits) of bFGF in fibroblast
18) Confidence 0.11 Published 2010 Journal OncoTargets and therapy Section Body Doc Link PMC2895781 Disease Relevance 1.88 Pain Relevance 0.04
Thalidomide inhibits the activity of basic fibroblast growth factor-2 (bFGF).
Negative_regulation (inhibits) of basic fibroblast growth factor-2 in fibroblast
19) Confidence 0.11 Published 2010 Journal OncoTargets and therapy Section Abstract Doc Link PMC2895781 Disease Relevance 0.24 Pain Relevance 0
Thalidomide inhibits the activity of basic fibroblast growth factor-2 (bFGF).
Negative_regulation (inhibits) of bFGF in fibroblast
20) Confidence 0.11 Published 2010 Journal OncoTargets and therapy Section Abstract Doc Link PMC2895781 Disease Relevance 0.24 Pain Relevance 0

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