INT69782

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Context Info
Confidence 0.78
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 14
Disease Relevance 8.44
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (MYOC) extracellular region (MYOC) structural molecule activity (MYOC)
cilium (MYOC)
Anatomy Link Frequency
meshwork 2
sclera 1
ciliary bodies 1
choroids 1
MYOC (Homo sapiens)
Pain Link Frequency Relevance Heat
dexamethasone 49 99.50 Very High Very High Very High
cINOD 2 89.92 High High
Inflammation 61 87.16 High High
agonist 9 86.24 High High
anesthesia 12 60.60 Quite High
corticosteroid 1 49.68 Quite Low
cytokine 35 34.08 Quite Low
chemokine 1 32.96 Quite Low
Potency 3 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Glaucoma 353 99.60 Very High Very High Very High
Myopia 480 98.88 Very High Very High Very High
Ocular Toxicity (including Many Sub-types) 2 94.52 High High
Stress 9 92.16 High High
INFLAMMATION 66 89.68 High High
Skin Diseases 1 87.72 High High
Refractive Errors 12 84.40 Quite High
Ocular Hypertension 56 80.64 Quite High
Death 3 77.60 Quite High
Photophobia 3 71.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our recent studies of TIGR's genomic structure have shown motifs in the promoter region that suggest a basis by which multiple hormonal/environmental stimuli can regulate TIGR production and by which putative genetic alterations could lead to an overexpression of the protein.
Gene_expression (production) of TIGR
1) Confidence 0.78 Published 1997 Journal Ophthalmologica Section Abstract Doc Link 9176893 Disease Relevance 0.40 Pain Relevance 0.09
MYOC is expressed in many ocular tissues, including the trabecular meshwork, ciliary bodies, sclera, and choroids [31].
Gene_expression (expressed) of MYOC in sclera
2) Confidence 0.77 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2652017 Disease Relevance 1.08 Pain Relevance 0
At the 3' flanking region of the MYOC gene and also 3' to NGA19 (Figure 1), both rs2421853 and rs235858 showed significant association under all three genetic models tested (Table 3).
Gene_expression (region) of MYOC
3) Confidence 0.67 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2652017 Disease Relevance 0.23 Pain Relevance 0
The database of these clusters and corresponding tools can be accessed through TIGR (http://www.tigr.org/sybil/rcd).
Gene_expression (accessed) of TIGR
4) Confidence 0.65 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1366493 Disease Relevance 0.17 Pain Relevance 0
When a reanalysis was performed for a subset of our families (n=74) with siblings (n=95) having more severe myopia (-8.00D or less; this is the same threshold used in the Singapore case-control study), no association could be demonstrated between MYOC microsatellites (both NGA17 and NGA19) and myopia under any genetic models tested (data not shown).
Gene_expression (microsatellites) of MYOC associated with myopia
5) Confidence 0.59 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2652017 Disease Relevance 0.69 Pain Relevance 0
Given that only the coding region of CYP1B1 and MYOC was sequenced, it is possible that a promoter or another non-coding variant may be present in heterozygous patients and among those who had no mutations.
Gene_expression (region) of MYOC
6) Confidence 0.51 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2901188 Disease Relevance 0.84 Pain Relevance 0
Screening of CYP1B1 and MYOC in Moroccan families with primary congenital glaucoma: Three novel mutations in CYP1B1

Purpose

Gene_expression (Screening) of MYOC associated with glaucoma
7) Confidence 0.46 Published 2010 Journal Molecular Vision Section Title Doc Link PMC2901188 Disease Relevance 0.44 Pain Relevance 0
Then the coding exons of MYOC were sequenced in patients who had no mutation in CYP1B1 or carried heterozygous CYP1B1 mutation.
Gene_expression (exons) of MYOC
8) Confidence 0.45 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2901188 Disease Relevance 0.38 Pain Relevance 0.06
It has been reported that glucocorticoids increase myocilin expression in trabecular meshwork cells, and that this protein may have an etiological role in steroid-induced glaucoma [20,21].
Gene_expression (expression) of myocilin in meshwork associated with glaucoma
9) Confidence 0.38 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790480 Disease Relevance 0.81 Pain Relevance 0.23
MYOC is expressed in many ocular tissues, including the trabecular meshwork, ciliary bodies, sclera, and choroids [31].
Gene_expression (expressed) of MYOC in choroids
10) Confidence 0.26 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2652017 Disease Relevance 1.08 Pain Relevance 0
MYOC is expressed in many ocular tissues, including the trabecular meshwork, ciliary bodies, sclera, and choroids [31].
Gene_expression (expressed) of MYOC in meshwork
11) Confidence 0.26 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2652017 Disease Relevance 1.08 Pain Relevance 0
MYOC is expressed in many ocular tissues, including the trabecular meshwork, ciliary bodies, sclera, and choroids [31].
Gene_expression (expressed) of MYOC in ciliary bodies
12) Confidence 0.26 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2652017 Disease Relevance 1.08 Pain Relevance 0
inhibited the dexamethasone-induced increase in the expression of the endogenous genes myocilin and fibronectin [Zhang et al., 2005b].
Gene_expression (expression) of myocilin associated with dexamethasone
13) Confidence 0.13 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2716050 Disease Relevance 0.08 Pain Relevance 0.14
Interestingly, this was observed for genes that are activated by glucocorticoids (MKP-1, myocilin, fibronectin) and for genes that are repressed in response to glucocorticoids (TNF?
Gene_expression (fibronectin) of myocilin
14) Confidence 0.11 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2716050 Disease Relevance 0.07 Pain Relevance 0.09

General Comments

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