INT69784

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Context Info
Confidence 0.48
First Reported 1997
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 5.67
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (MYOC) extracellular region (MYOC) structural molecule activity (MYOC)
cilium (MYOC)
MYOC (Homo sapiens)
Pain Link Frequency Relevance Heat
corticosteroid 2 80.84 Quite High
cINOD 2 62.72 Quite High
anesthesia 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Glaucoma 243 99.88 Very High Very High Very High
Myopia 400 99.80 Very High Very High Very High
Stress 6 91.52 High High
Ocular Hypertension 37 85.92 High High
INFLAMMATION 2 61.28 Quite High
Disease 46 60.88 Quite High
Blindness 2 60.08 Quite High
Refractive Errors 10 43.84 Quite Low
Hyperopia 5 41.20 Quite Low
Syndrome 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, the leucine zippers in the structure were related to TIGR-TIGR oligomerization that was shown to occur with native and recombinant TIGR protein.
TIGR Binding (oligomerization) of
1) Confidence 0.48 Published 1997 Journal Ophthalmologica Section Abstract Doc Link 9176893 Disease Relevance 0.51 Pain Relevance 0.10
In addition, the leucine zippers in the structure were related to TIGR-TIGR oligomerization that was shown to occur with native and recombinant TIGR protein.
TIGR Binding (oligomerization) of
2) Confidence 0.48 Published 1997 Journal Ophthalmologica Section Abstract Doc Link 9176893 Disease Relevance 0.51 Pain Relevance 0.10
Interestingly, a few large studies of genome-wide linkage analysis for myopia families did not show linkage to the MYOC locus [13,16,19,23].
MYOC Neg (not) Binding (linkage) of associated with myopia
3) Confidence 0.42 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2652017 Disease Relevance 0.35 Pain Relevance 0
At the 3' flanking region of the MYOC gene and also 3' to NGA19 (Figure 1), both rs2421853 and rs235858 showed significant association under all three genetic models tested (Table 3).
MYOC Binding (association) of
4) Confidence 0.37 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2652017 Disease Relevance 0.22 Pain Relevance 0
The most updated HapMap data (release 21, phase II, July, 2006) indicate that the MYOC gene is bounded within a 60 kb region by two recombination hotspots and hence separated from other flanking genes by these hotspots.
MYOC Binding (bounded) of
5) Confidence 0.37 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2652017 Disease Relevance 0.22 Pain Relevance 0
The present study is the largest of these four to test the association between MYOC markers and high myopia in that it involved a total of 162 families with 233 severely myopic offspring.
MYOC Binding (association) of associated with myopia
6) Confidence 0.32 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2652017 Disease Relevance 0.80 Pain Relevance 0
Three small studies tested the association between MYOC and myopia but results conflicted [36-38].
MYOC Binding (association) of associated with myopia
7) Confidence 0.31 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2652017 Disease Relevance 1.05 Pain Relevance 0
MYOC mutation associated with PCG
MYOC Binding (mutation) of associated with glaucoma
8) Confidence 0.25 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2901188 Disease Relevance 1.19 Pain Relevance 0
In summary, we identified three CYP1B1 novel mutations in addition to the eight previously reported, and one MYOC mutation previously associated with POAG.
MYOC Binding (associated) of associated with glaucoma
9) Confidence 0.25 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2901188 Disease Relevance 0.81 Pain Relevance 0

General Comments

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