INT69785

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Context Info
Confidence 0.70
First Reported 1997
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 10
Disease Relevance 6.24
Pain Relevance 1.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (MYOC) extracellular region (MYOC) structural molecule activity (MYOC)
cilium (MYOC)
Anatomy Link Frequency
meshwork 5
eye 1
outflow 1
fibroblast 1
MYOC (Homo sapiens)
Pain Link Frequency Relevance Heat
dexamethasone 133 99.92 Very High Very High Very High
agonist 22 99.92 Very High Very High Very High
cINOD 5 99.44 Very High Very High Very High
corticosteroid 2 98.80 Very High Very High Very High
cytokine 95 89.60 High High
Inflammation 163 89.36 High High
Inflammatory mediators 3 65.76 Quite High
chemokine 3 51.60 Quite High
Inflammatory marker 3 12.56 Low Low
Potency 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 177 98.72 Very High Very High Very High
Stress 11 97.64 Very High Very High Very High
Ocular Hypertension 92 96.88 Very High Very High Very High
Glaucoma 48 95.80 Very High Very High Very High
Hyperglycemia 3 88.48 High High
Apoptosis 7 87.88 High High
Skin Atrophy 3 85.60 High High
Ocular Toxicity (including Many Sub-types) 6 85.20 High High
Skin Diseases 3 78.40 Quite High
Hypersensitivity 12 76.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pharmacological evaluation showed that basic fibroblast growth factory and transforming growth factor beta decreased the GC induction of TIGR, and certain nonsteroidal anti-inflammatory drugs protected against both GC- and oxidation-induced stress responses in HTM cells.
Positive_regulation (induction) of TIGR in fibroblast associated with stress, inflammation and cinod
1) Confidence 0.70 Published 1997 Journal Ophthalmologica Section Abstract Doc Link 9176893 Disease Relevance 0.51 Pain Relevance 0.13
The very large, progressive induction of TIGR combined with specific structural features of its cDNA suggested that TIGR should be considered a candidate gene for outflow obstruction in glaucoma.
Positive_regulation (induction) of TIGR in outflow associated with glaucoma
2) Confidence 0.70 Published 1997 Journal Ophthalmologica Section Abstract Doc Link 9176893 Disease Relevance 0.32 Pain Relevance 0.05
This protein was originally known as the trabecular meshwork-induced glucocorticoid response protein (TIGR) [26-28].
Positive_regulation (induced) of glucocorticoid response protein in meshwork
3) Confidence 0.69 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2652017 Disease Relevance 0.89 Pain Relevance 0
This protein was originally known as the trabecular meshwork-induced glucocorticoid response protein (TIGR) [26-28].
Positive_regulation (induced) of TIGR in meshwork
4) Confidence 0.67 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2652017 Disease Relevance 0.94 Pain Relevance 0
Dexamethasone and oxidative damage also lead to increase of trabecular meshwork inducible glucocorticoid response (TIGR) protein [23].
Positive_regulation (increase) of TIGR in meshwork associated with dexamethasone
5) Confidence 0.66 Published 2008 Journal The Open Ophthalmology Journal Section Body Doc Link PMC2694598 Disease Relevance 1.03 Pain Relevance 0.05
Whether the sequence CATCTG forms part of the motifs for any enhancer downstream of the MYOC gene remains to be determined and is worthy of further investigation.
Positive_regulation (enhancer) of MYOC
6) Confidence 0.50 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2652017 Disease Relevance 0.07 Pain Relevance 0
We have found that BOL-303242-X behaves as a partial agonist compared both to dexamethasone at increasing myocilin protein levels and to the gene expression of cultured monkey trabecular meshwork cells [19,48].
Positive_regulation (increasing) of myocilin in meshwork associated with agonist and dexamethasone
7) Confidence 0.34 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790480 Disease Relevance 0.81 Pain Relevance 0.35
A recent study also demonstrated that BOL-303242-X behaves as a partial agonist at increasing myocilin protein levels and gene expression in monkey trabecular meshwork cells [19].
Spec (partial) Positive_regulation (increasing) of myocilin in meshwork associated with agonist
8) Confidence 0.34 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790480 Disease Relevance 1.18 Pain Relevance 0.40
Our observations, together with data indicating that the compound acts as a partial agonist to increase myocilin protein and mRNA levels when incubated with monkey trabecular meshwork cells [19], and that the compound shows a reduced propensity to elevate IOP in normotensive rabbits [18], suggest that this novel SEGRA compound may be a new option for the treatment of chronic inflammatory conditions of the eye, and may provide a beneficial side-effect profile in comparison with classical steroids.



Positive_regulation (increase) of myocilin in eye associated with inflammation, agonist and ocular hypertension
9) Confidence 0.23 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790480 Disease Relevance 0.41 Pain Relevance 0.29
Interestingly, this was observed for genes that are activated by glucocorticoids (MKP-1, myocilin, fibronectin) and for genes that are repressed in response to glucocorticoids (TNF?
Positive_regulation (activated) of myocilin
10) Confidence 0.04 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2716050 Disease Relevance 0.07 Pain Relevance 0.09

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