INT69786

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Context Info
Confidence 0.50
First Reported 1997
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.36
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (MYOC) extracellular region (MYOC) structural molecule activity (MYOC)
cilium (MYOC)
Anatomy Link Frequency
meshwork 2
MYOC (Homo sapiens)
Pain Link Frequency Relevance Heat
dexamethasone 49 99.82 Very High Very High Very High
cINOD 2 89.92 High High
Inflammation 61 87.52 High High
agonist 9 86.24 High High
corticosteroid 1 49.68 Quite Low
cytokine 35 34.08 Quite Low
chemokine 1 32.96 Quite Low
Potency 3 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
rheumatoid arthritis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Glaucoma 5 95.96 Very High Very High Very High
Ocular Toxicity (including Many Sub-types) 2 94.88 High High
Stress 6 92.16 High High
INFLAMMATION 66 89.68 High High
Skin Diseases 1 88.08 High High
Death 2 77.60 Quite High
Ocular Hypertension 8 64.56 Quite High
Cataract 2 55.04 Quite High
Diabetic Macular Edema 3 49.12 Quite Low
Infection 1 47.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our recent studies of TIGR's genomic structure have shown motifs in the promoter region that suggest a basis by which multiple hormonal/environmental stimuli can regulate TIGR production and by which putative genetic alterations could lead to an overexpression of the protein.
Positive_regulation (lead) of Gene_expression (production) of TIGR
1) Confidence 0.50 Published 1997 Journal Ophthalmologica Section Abstract Doc Link 9176893 Disease Relevance 0.40 Pain Relevance 0.09
It has been reported that glucocorticoids increase myocilin expression in trabecular meshwork cells, and that this protein may have an etiological role in steroid-induced glaucoma [20,21].
Positive_regulation (increase) of Gene_expression (expression) of myocilin in meshwork associated with glaucoma
2) Confidence 0.34 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790480 Disease Relevance 0.81 Pain Relevance 0.23
inhibited the dexamethasone-induced increase in the expression of the endogenous genes myocilin and fibronectin [Zhang et al., 2005b].
Positive_regulation (increase) of Gene_expression (expression) of myocilin associated with dexamethasone
3) Confidence 0.08 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2716050 Disease Relevance 0.08 Pain Relevance 0.14
Interestingly, this was observed for genes that are activated by glucocorticoids (MKP-1, myocilin, fibronectin) and for genes that are repressed in response to glucocorticoids (TNF?
Positive_regulation (activated) of Gene_expression (fibronectin) of myocilin
4) Confidence 0.08 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2716050 Disease Relevance 0.07 Pain Relevance 0.09

General Comments

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