INT69789

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Context Info
Confidence 0.36
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 5.08
Pain Relevance 2.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Fn1) cell adhesion (Fn1) proteinaceous extracellular matrix (Fn1)
extracellular matrix organization (Fn1)
Anatomy Link Frequency
extracellular matrix 2
poly 1
choroid plexus 1
plaque 1
Fn1 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 23 99.04 Very High Very High Very High
Inflammation 144 98.72 Very High Very High Very High
chemokine 52 98.00 Very High Very High Very High
imagery 33 95.24 Very High Very High Very High
Mechanotransduction 19 94.32 High High
Calcitonin gene-related peptide 6 92.52 High High
Somatostatin 6 92.28 High High
Action potential 46 89.12 High High
cytokine 37 86.20 High High
Enkephalin 3 81.00 Quite High
Disease Link Frequency Relevance Heat
Death 14 99.58 Very High Very High Very High
Injury 62 99.28 Very High Very High Very High
Adhesions 27 98.88 Very High Very High Very High
INFLAMMATION 157 98.72 Very High Very High Very High
Atherosclerosis 18 98.40 Very High Very High Very High
Shock 1 98.16 Very High Very High Very High
Cancer 142 97.04 Very High Very High Very High
Targeted Disruption 3 96.48 Very High Very High Very High
Asthma 95 94.48 High High
Adenocarcinoma 5 83.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Animal experiments have shown antiatherosclerotic effects with ezetimibe therapy, in part possibly mediated by nonlipid (pleiotropic) mechanisms, the significance of which is controversial.62–68 In apoE knockout (ko) mice, aortic lesion formation was significantly reduced by ezetimibe therapy.62 Ezetimibe treatment resulted in a significant reduction in plaque size and macrophage and fibronectin extra domain-B immunoreactivity in brachiocephalic lesions, indicating plaque regression.66 Similar results were also shown with high-intensity (7 T) magnetic resonance imaging.63
fibronectin Binding (immunoreactivity) of in plaque associated with targeted disruption, atherosclerosis and imagery
1) Confidence 0.36 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988620 Disease Relevance 0.49 Pain Relevance 0.05
It associates with FN and a variety of other ECM proteins including laminin and fibrinogen [13].
FN Binding (associates) of
2) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954173 Disease Relevance 0.57 Pain Relevance 0.04
Integrin clustering upon binding to extracellular matrix components, such as FN, or growth factor binding to their receptors results in activation of FAK [41].
FN Binding (binding) of in extracellular matrix
3) Confidence 0.12 Published 2008 Journal Mol Cell Biochem Section Body Doc Link PMC2758386 Disease Relevance 0.20 Pain Relevance 0.11
A similar effect by VIP was also observed in cell migration to fibronectin.
fibronectin Binding (migration) of
4) Confidence 0.10 Published 1997 Journal Cancer Lett. Section Abstract Doc Link 9177465 Disease Relevance 0.60 Pain Relevance 0.52
A similar effect by VIP was also observed in cell migration to fibronectin.
fibronectin Binding (migration) of
5) Confidence 0.10 Published 1997 Journal Cancer Lett. Section Abstract Doc Link 18372531 Disease Relevance 0.60 Pain Relevance 0.52
Thus, we probed these interactions by using poly-L-lysine and fibronectin, which have different cell adhesion characteristics.
fibronectin Binding (interactions) of in poly associated with adhesions
6) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2627935 Disease Relevance 0.25 Pain Relevance 0.24
Endothelial cells of the choroid plexus and other CVO express proteoglycans, fibronectin and other extracellular matrix proteins [33,34], which may bind Gf.
fibronectin Binding (bind) of in choroid plexus
7) Confidence 0.09 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2978145 Disease Relevance 0.65 Pain Relevance 0.36
The main function of nidogen in the basement-membrane is to connect networks of collagen IV and laminin [68], but nidogen also binds perlecan [69], fibulins [70] and fibronectin [71].
fibronectin Binding (binds) of
8) Confidence 0.04 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC535545 Disease Relevance 0.12 Pain Relevance 0
Binding to fibronectin is not the same as GAGs, and this may also account for discrepancies between in vivo and in vitro activities of our variants.
fibronectin Binding (Binding) of
9) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909905 Disease Relevance 0 Pain Relevance 0.22
Collagens, elastin, structural glycoproteins (eg. fibronectin, laminin, SPARC and nidogen), proteoglycans (eg. biglycan) and glycosaminoglycans are the major components of endometrial matrix, and can act as ligands for both cell-cell and cell-matrix interactions [37].
fibronectin Binding (interactions) of
10) Confidence 0.03 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC535545 Disease Relevance 0.18 Pain Relevance 0
Collagens, elastin, structural glycoproteins (eg. fibronectin, laminin, SPARC and nidogen), proteoglycans (eg. biglycan) and glycosaminoglycans are the major components of endometrial matrix, and can act as ligands for both cell-cell and cell-matrix interactions [37].
fibronectin Binding (ligands) of
11) Confidence 0.03 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC535545 Disease Relevance 0.18 Pain Relevance 0
In addition, it has been purported that certain receptors may be involved in sensation of tissue injury and cell death, such as those that recognize extracellular matrix fragments (such as hyaluronan or fibronectin) or necrotic debris (including S100 and heat shock proteins and HMGB1).
fibronectin Binding (recognize) of in extracellular matrix associated with shock, injury and death
12) Confidence 0.02 Published 2007 Journal Yale J Biol Med Section Body Doc Link PMC1994795 Disease Relevance 0.94 Pain Relevance 0.10
TSP1 is involved in the formation and resolution of a fibrin clot and binds to many proteins and proteases.(16) TSP1 interacts with heparan sulfates, proteoglycans, integrins, fibrinogen and fibronectin.(18) It also binds to components of the fibrinolytic system (plasminogen, urokinase and its inhibitor PAI-1)(19,20) and to cathepsin G and elastase.(21)
fibronectin Binding (binds) of
13) Confidence 0.02 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2600574 Disease Relevance 0.31 Pain Relevance 0.03

General Comments

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