INT6979

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Context Info
Confidence 0.67
First Reported 1986
Last Reported 2010
Negated 10
Speculated 4
Reported most in Abstract
Documents 206
Total Number 210
Disease Relevance 50.79
Pain Relevance 44.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CA2) extracellular space (CA2) lyase activity (CA2)
response to stress (CA2) cytoplasm (CA2)
Anatomy Link Frequency
external 7
plasma 7
neurons 6
neutrophils 4
smooth muscle 3
CA2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 1069 100.00 Very High Very High Very High
Calcium channel 266 100.00 Very High Very High Very High
addiction 179 100.00 Very High Very High Very High
agonist 701 99.98 Very High Very High Very High
Opioid 429 99.98 Very High Very High Very High
Kinase C 172 99.98 Very High Very High Very High
qutenza 250 99.92 Very High Very High Very High
Nicotine 15 99.66 Very High Very High Very High
Catecholamine 55 99.52 Very High Very High Very High
Glutamate 213 99.50 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 757 99.96 Very High Very High Very High
Parkinson's Disease 27 99.88 Very High Very High Very High
Apoptosis 813 99.76 Very High Very High Very High
Pheochromocytoma 3 99.64 Very High Very High Very High
Volume Depletion And Dehydration 207 99.52 Very High Very High Very High
Hypercalcemia 41 99.28 Very High Very High Very High
Pancreatitis 84 99.24 Very High Very High Very High
Death 314 99.16 Very High Very High Very High
Hyperplasia 15 99.16 Very High Very High Very High
Muscular Spasm 29 99.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
All drug treatments markedly increased the enzymatic activity of nuclear Ca2+/calmodulin (CaM) kinase IV (CaMKIV), a major neuronal CREB kinase, in PFCX.
Positive_regulation (increased) of Ca2 in PFCX associated with urological neuroanatomy
1) Confidence 0.67 Published 2004 Journal Neuropsychopharmacology Section Abstract Doc Link 15138445 Disease Relevance 0.43 Pain Relevance 0.70
The authors sought to determine whether nontoxic concentrations of ethanol cause a direct elevation of Ca2+i in arterial smooth muscle and endothelium.
Spec (whether) Positive_regulation (elevation) of Ca2 in endothelium
2) Confidence 0.47 Published 1996 Journal Reg Anesth Section Abstract Doc Link 8826019 Disease Relevance 0.42 Pain Relevance 0.22
Upregulation of the Ca2+ channel alpha2/delta1 subunit, gamma-aminobutyric acid A receptor alpha5 subunit, Na+ channels and nicotinic acetylcholine receptors in the DRG and dorsal spinal cord indicates their potential roles in neuropathic pain control.
Positive_regulation (Upregulation) of Ca2 in spinal cord associated with dorsal root ganglion, neuropathic pain and spinal cord
3) Confidence 0.45 Published 2005 Journal Curr. Opin. Mol. Ther. Section Abstract Doc Link 16370375 Disease Relevance 0.78 Pain Relevance 0.74
In conclusion, we show that extracts from Echinacea induce transient increases of cytosolic Ca2+ levels when applied to HEK293 cells, and that this increase can be attributed to a subset of lipohilic Echinacea constituents.
Positive_regulation (increases) of Ca2
4) Confidence 0.43 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3002894 Disease Relevance 0 Pain Relevance 0.12
Based on these data, we reveal an Echinacea-induced stimulation of an increase in cytosolic Ca2+ that is not-CB2-dependent, and is not associated with the major alkamides of E. purpurea.
Positive_regulation (increase) of Ca2
5) Confidence 0.43 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3002894 Disease Relevance 0.17 Pain Relevance 0.26
After Ca2+-containing medium is introduced, a sustained increase in cytosolic Ca2+ is observed for both treatments (Figure 6A, 6B).
Positive_regulation (increase) of Ca2
6) Confidence 0.43 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3002894 Disease Relevance 0 Pain Relevance 0.03
We tested for the possible involvement of the IP3 receptor in the Echinacea-induction of intracellular Ca2+ release by evaluating the effect of 2-aminoethoxydiphenyl borate (2-APB), an IP3 receptor antagonist, on Echinacea-induced cytosolic Ca2+ increase.
Positive_regulation (increase) of Ca2 associated with antagonist
7) Confidence 0.43 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3002894 Disease Relevance 0 Pain Relevance 0.05
Restoration of external Ca2+ following thapsigargin-treatment indicates the function of SOCE, which can be observed as an increase in cytosolic Ca2+ [16].
Positive_regulation (increase) of Ca2 in external
8) Confidence 0.43 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3002894 Disease Relevance 0 Pain Relevance 0.06
An artificial increase of intracellular Ca2+ in the submicromolar range, using a very low dose of the Ca2+ ionophore ionomycin, or a threefold increase of the external Ca2+ concentration suffices to lift the xenon-induced metaphase block; the cells enter anaphase despite the presence of xenon and complete cell division.
Positive_regulation (increase) of Ca2 in external
9) Confidence 0.41 Published 1999 Journal Pflugers Arch. Section Abstract Doc Link 10087152 Disease Relevance 0 Pain Relevance 0.04
An artificial increase of intracellular Ca2+ in the submicromolar range, using a very low dose of the Ca2+ ionophore ionomycin, or a threefold increase of the external Ca2+ concentration suffices to lift the xenon-induced metaphase block; the cells enter anaphase despite the presence of xenon and complete cell division.
Positive_regulation (increase) of Ca2 in external
10) Confidence 0.41 Published 1999 Journal Pflugers Arch. Section Abstract Doc Link 10087152 Disease Relevance 0 Pain Relevance 0.09
Ethanol alone, at doses of 2-5% (v/v) also caused a sustained elevation in Ca2+i of physiologically significant magnitude.
Positive_regulation (elevation) of Ca2
11) Confidence 0.41 Published 1996 Journal Reg Anesth Section Body Doc Link 8826019 Disease Relevance 0 Pain Relevance 0
Ca2+ releasing speed was prominently accelerated in this patient.
Positive_regulation (accelerated) of Ca2
12) Confidence 0.41 Published 1991 Journal Masui Section Abstract Doc Link 1875546 Disease Relevance 0.79 Pain Relevance 0.14
Histamine (10 microM) as a positive control caused an increase in Ca2+i, as expected.
Positive_regulation (increase) of Ca2
13) Confidence 0.41 Published 1996 Journal Reg Anesth Section Body Doc Link 8826019 Disease Relevance 0 Pain Relevance 0
Long-term (18 hr) pretreatment of SK-N-SH cells with pertussis (100 ng/ml) or cholera toxins (10 nM) had no effect on NIC or KCl-induced [Ca2+]i accumulation.
Positive_regulation (accumulation) of Ca2 in SK-N-SH associated with bordatella infection, nicotine and vibrio infection
14) Confidence 0.41 Published 1989 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 2548492 Disease Relevance 0.33 Pain Relevance 0.39
When cells were treated with NaCN, [Ca2+]i increased in a time- and NaCN concentration-dependent manner.
Positive_regulation (increased) of Ca2
15) Confidence 0.41 Published 1994 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 7519371 Disease Relevance 0 Pain Relevance 0
Carbachol (1 mm) was applied to evoke a transient increase in cytoplasmic Ca2+.
Positive_regulation (increase) of Ca2
16) Confidence 0.41 Published 2003 Journal Anesthesiology Section Body Doc Link 14508321 Disease Relevance 0 Pain Relevance 0
This increase occurred via activation of plasma membrane Ca2+ channels.
Positive_regulation (activation) of Ca2 in plasma
17) Confidence 0.40 Published 1994 Journal Neuroreport Section Abstract Doc Link 7919177 Disease Relevance 0.09 Pain Relevance 0.21
Short trains of supramaximal electrical stimuli applied to one end of the nerve as well as bath application of capsaicin resulted in an increase in the free intracellular Ca2+ concentration.
Positive_regulation (increase) of Ca2 in nerve associated with qutenza
18) Confidence 0.40 Published 1999 Journal Pain Section Abstract Doc Link 10431719 Disease Relevance 0.31 Pain Relevance 0.59
The release is accompanied by a dose-dependent increase in Ca2+ efflux and is capable of sustaining an initial maximal contraction.
Positive_regulation (increase) of Ca2
19) Confidence 0.40 Published 1986 Journal Am. J. Physiol. Section Abstract Doc Link 2420205 Disease Relevance 0 Pain Relevance 0.20
Collectively, these results suggest that the capsaicin-induced apoptosis in the HepG2 cells may result from the activation of a PLC-dependent intracellular Ca2+ release pathway, and it is further suggested that capsaicin may be valuable for the therapeutic intervention of human hepatomas.
Positive_regulation (activation) of Ca2 associated with qutenza, hepatocellular cancer and apoptosis
20) Confidence 0.39 Published 2005 Journal Arch. Pharm. Res. Section Abstract Doc Link 15742812 Disease Relevance 0.86 Pain Relevance 0.86

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