INT69803

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Context Info
Confidence 0.62
First Reported 1997
Last Reported 2009
Negated 0
Speculated 3
Reported most in Abstract
Documents 3
Total Number 6
Disease Relevance 0.79
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Edn1) extracellular region (Edn1) cell-cell signaling (Edn1)
cytoplasm (Edn1)
Anatomy Link Frequency
pituitary gland 6
Edn1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 6 100.00 Very High Very High Very High
Percutaneous transluminal coronary angioplasty 3 100.00 Very High Very High Very High
mu opioid receptor 3 99.66 Very High Very High Very High
Opioid 3 99.62 Very High Very High Very High
Endogenous opioid 3 99.58 Very High Very High Very High
lidocaine 1 94.68 High High
opioid receptor 3 84.32 Quite High
Angina 1 75.00 Quite High
local anesthetic 1 75.00 Quite High
ischemia 1 57.68 Quite High
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 2 98.32 Very High Very High Very High
Pulmonary Disease 1 89.32 High High
Stress 1 76.64 Quite High
Stable Angina Pectoris 1 75.00 Quite High
Adult Respiratory Distress Syndrome 1 75.00 Quite High
Atherosclerotic Plaque 1 75.00 Quite High
Coronary Artery Disease 1 75.00 Quite High
Volume Depletion And Dehydration 3 72.00 Quite High
Death 2 5.00 Very Low Very Low Very Low
Dysmenorrhea 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Are mu-opioid receptors involved in the control of endothelin-1 release from the pituitary gland in normal and dehydrated rats?
Regulation (control) of Localization (release) of endothelin-1 in pituitary gland associated with mu opioid receptor
1) Confidence 0.62 Published 1997 Journal Regul. Pept. Section Title Doc Link 9178351 Disease Relevance 0.06 Pain Relevance 0.19
The objective of the present study was to investigate whether the endogenous opioids are involved in the control of endothelin-1 release from the pituitary gland.
Spec (whether) Regulation (control) of Localization (release) of endothelin-1 in pituitary gland associated with endogenous opioid
2) Confidence 0.62 Published 1997 Journal Regul. Pept. Section Abstract Doc Link 9178351 Disease Relevance 0 Pain Relevance 0.18
CONCLUSIONS: (1) An elevation of irET-1 in the pituitary gland and peripheral circulation in dehydrated animals may play a role in maintaining of water-electrolyte balance. (2) The mu-opioid system appears to control the ET-1 release from the pituitary in normal and dehydrated animals.
Spec (appears) Regulation (control) of Localization (release) of ET-1 in pituitary gland associated with opioid
3) Confidence 0.62 Published 1997 Journal Regul. Pept. Section Abstract Doc Link 9178351 Disease Relevance 0.07 Pain Relevance 0.16
We examined the effects of procaine, bupivacaine, and ropivacaine on experimentally evoked PAP increase and ET-1 release.
Spec (examined) Regulation (effects) of Localization (release) of ET-1
4) Confidence 0.43 Published 2009 Journal Anesth. Analg. Section Abstract Doc Link 19690261 Disease Relevance 0.36 Pain Relevance 0.17
Genes such as gelatinase A (MMP2), cathepsin L, tissue inhibitor metalloproteinases 2 (TIMP2) and 3 (TIMP3), plasminogen activator inhibitor1 (PAI1), tissue type plasminogen activator (tPA), urokinase plasminogen activator (uPA), endothelin 1, calponin, carboxypeptidase D and calponin acidic were down regulated.
Regulation (regulated) of Localization (tissue) of endothelin 1 associated with metalloproteinase
5) Confidence 0.19 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548144 Disease Relevance 0 Pain Relevance 0.05
To assess the effects of percutaneous transluminal coronary angioplasty on endothelin-1 (ET-1) release, we assessed ET-1 concentrations at different sites of the coronary circulation in patients submitted to elective procedures.
Regulation (effects) of Localization (release) of endothelin-1 associated with percutaneous transluminal coronary angioplasty
6) Confidence 0.16 Published 1999 Journal Am. J. Cardiol. Section Abstract Doc Link 10569670 Disease Relevance 0.30 Pain Relevance 0.23

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