INT69822

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.39
First Reported 1997
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 2.98
Pain Relevance 2.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Ptger3)
Anatomy Link Frequency
cortex 2
brain 1
synapse 1
PGE2 1
Ptger3 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 12 99.84 Very High Very High Very High
Kappa opioid receptor 2 99.80 Very High Very High Very High
Pain 18 99.52 Very High Very High Very High
antagonist 4 98.80 Very High Very High Very High
long-term potentiation 116 97.92 Very High Very High Very High
cerebral cortex 6 94.16 High High
allodynia 6 91.96 High High
cINOD 1 90.12 High High
aspirin 1 88.96 High High
noradrenaline 8 86.80 High High
Disease Link Frequency Relevance Heat
Fever 17 98.12 Very High Very High Very High
Pain 15 98.12 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 3 97.48 Very High Very High Very High
Inflammatory Breast Neoplasms 34 96.56 Very High Very High Very High
Cancer 20 96.40 Very High Very High Very High
Neuropathic Pain 6 91.96 High High
INFLAMMATION 29 89.88 High High
Metastasis 3 88.64 High High
Cv General 2 Under Development 2 87.76 High High
Breast Cancer 14 87.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mutual interactions of the presynaptic histamine H3 and prostaglandin EP3 receptors on the noradrenergic terminals in the mouse brain.
EP3 Binding (interactions) of in brain
1) Confidence 0.39 Published 1997 Journal Neuroscience Section Title Doc Link 9178880 Disease Relevance 0 Pain Relevance 0.26
PGE2 acts by interacting with four subtypes of PGE receptor, the EP1, EP2, EP3 and EP4 receptors.
EP3 Binding (interacting) of in PGE2
2) Confidence 0.36 Published 1998 Journal Nature Section Abstract Doc Link 9751056 Disease Relevance 0.85 Pain Relevance 0.22
Functional evidence for interaction between prostaglandin EP3 and kappa-opioid receptor pathways in tactile pain induced by human immunodeficiency virus type-1 (HIV-1) glycoprotein gp120.
prostaglandin EP3 Binding (interaction) of associated with pain, acquired immune deficiency syndrome or hiv infection and kappa opioid receptor
3) Confidence 0.30 Published 2003 Journal Neuropharmacology Section Title Doc Link 12814662 Disease Relevance 0.97 Pain Relevance 1.15
We studied whether interactions between the presynaptic histamine H3 and prostaglandin EP3 receptors on the noradrenergic neurons of the mouse brain cortex occur.
EP3 Binding (interactions) of in cortex
4) Confidence 0.30 Published 1997 Journal Neuroscience Section Abstract Doc Link 9178880 Disease Relevance 0 Pain Relevance 0.17
This involves interesting and efficient trafficking of EP2 and EP3, both of which are located at the postsynaptic sites in the neurons of the visual cortex.
EP3 Binding (trafficking) of in cortex
5) Confidence 0.20 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759147 Disease Relevance 0 Pain Relevance 0.52
This bidirectional trafficking of EP2 and EP3 is similar to the trafficking of AMPA receptors in LTP.
EP3 Binding (trafficking) of associated with long-term potentiation
6) Confidence 0.20 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759147 Disease Relevance 0 Pain Relevance 0.25
Bidirectional trafficking of the two subtypes, EP2 and EP3, which have reciprocal actions is one of the ways by which synaptic functions may be regulated.
EP3 Binding (trafficking) of
7) Confidence 0.20 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759147 Disease Relevance 0.21 Pain Relevance 0.03
The dynamic force causing this trafficking might be provided by as yet unknown EP2- and EP3-interacting proteins, similar to the AMPA receptor-interacting proteins involved in the so-called silent synapse mechanisms (Harris and Lim, 2001; Barry and Ziff, 2002; Collingridge et al. 2004).
EP3 Binding (interacting) of in synapse
8) Confidence 0.19 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759147 Disease Relevance 0 Pain Relevance 0.19
Neither antagonists of the EP1 or EP2 prostanoid receptors nor agonists of the EP3 receptor, which is recognized as a downregulatory receptor, had any significant effect on biological activities of IBC tumor cells.
EP3 receptor Binding (recognized) of associated with inflammatory breast neoplasms, cancer, antagonist and agonist
9) Confidence 0.05 Published 2009 Journal Toxicological Sciences Section Body Doc Link PMC2769059 Disease Relevance 0.96 Pain Relevance 0.17

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox