INT6983

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Context Info
Confidence 0.41
First Reported 1985
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 18
Total Number 19
Disease Relevance 4.29
Pain Relevance 5.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ca2) extracellular space (Ca2) lyase activity (Ca2)
response to stress (Ca2) cytoplasm (Ca2)
Anatomy Link Frequency
astrocyte 4
sensory neuron 2
neuronal 2
CPA 2
livers 2
Ca2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 51 100.00 Very High Very High Very High
nMDA receptor 40 100.00 Very High Very High Very High
Kinase C 2 100.00 Very High Very High Very High
fluoxetine 11 99.88 Very High Very High Very High
agonist 22 99.60 Very High Very High Very High
tetrodotoxin 42 99.48 Very High Very High Very High
antagonist 63 99.46 Very High Very High Very High
Enkephalin 1 98.58 Very High Very High Very High
Morphine 4 98.32 Very High Very High Very High
Potency 2 98.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypoxia 149 100.00 Very High Very High Very High
Drug Induced Neurotoxicity 59 99.36 Very High Very High Very High
Stress 41 98.56 Very High Very High Very High
Morphine Dependence 2 98.32 Very High Very High Very High
Convulsion 99 98.16 Very High Very High Very High
Ganglion Cysts 22 97.12 Very High Very High Very High
Cataract 50 94.64 High High
Substance Withdrawal Syndrome 1 92.24 High High
Pressure And Volume Under Development 1 91.52 High High
Brain Hemorrhage 38 87.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chronic inhibition of intracellular Ca2+ release or protein kinase C activation significantly reduces the development of morphine dependence.
Negative_regulation (inhibition) of Positive_regulation (activation) of Ca2 associated with addiction, kinase c and morphine
1) Confidence 0.41 Published 1996 Journal Eur. J. Pharmacol. Section Title Doc Link 8739205 Disease Relevance 0.27 Pain Relevance 0.75
The increase of NO release as well as the reduced acid response were attenuated by pretreatment with L-NAME or coapplication of EGTA, and the latter inhibited the luminal increase of Ca2+.
Negative_regulation (inhibited) of Positive_regulation (increase) of Ca2
2) Confidence 0.38 Published 1999 Journal Dig. Dis. Sci. Section Abstract Doc Link 10080143 Disease Relevance 0 Pain Relevance 0.08
Fluoxetine also inhibited the K(+)-induced increase in intracellular free Ca2+ in fura-2 loaded synaptosomes.
Negative_regulation (inhibited) of Positive_regulation (increase) of Ca2 associated with fluoxetine
3) Confidence 0.38 Published 1992 Journal Life Sci. Section Abstract Doc Link 1608295 Disease Relevance 0 Pain Relevance 1.05
Irrespective of the order of addition the combination of FCCP with caffeine and or CPA completely prevented any anoxia induced rise in [Ca2+]i, (?
Negative_regulation (prevented) of Positive_regulation (induced) of Ca2 in CPA associated with hypoxia
4) Confidence 0.36 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.58 Pain Relevance 0
Thus, alkylating hepatotoxins given in vivo were examined for their ability to inhibit Ca2+ accumulation by plasma membrane vesicles isolated from livers of adult male rats.
Spec (examined) Negative_regulation (inhibit) of Spec (examined) Positive_regulation (accumulation) of Ca2 in livers
5) Confidence 0.36 Published 1985 Journal Mol. Pharmacol. Section Abstract Doc Link 4021997 Disease Relevance 0.09 Pain Relevance 0.21
The opioid receptor agonists ohmefentanyl (OMF, mu agonist), [D-Pen2,D-Pen5]enkephalin (DPDPE, delta agonist), and 66A-078 (kappa agonist) produced a marked suppression of the Ca2+ influx induced by high K+ depolarization.
Negative_regulation (suppression) of Positive_regulation (induced) of Ca2 associated with agonist, enkephalin and opioid receptor
6) Confidence 0.35 Published 1992 Journal Peptides Section Abstract Doc Link 1336191 Disease Relevance 0 Pain Relevance 0.57
The PTZ-stimulatory effects of both synapsin I phosphorylation and synaptosomal accumulation of Ca2+ were inhibited markedly by tetrodotoxin as well as by cobalt chloride and lanthanum chloride.
Negative_regulation (inhibited) of Positive_regulation (accumulation) of Ca2 associated with tetrodotoxin
7) Confidence 0.33 Published 1987 Journal Biochem. Pharmacol. Section Abstract Doc Link 3107572 Disease Relevance 0 Pain Relevance 0.26
Oxidative stress-induced lipid peroxidative damage of membranes might be a contributing factor in the loss of Ca2+ ATPase activity and accumulation of Ca2+, which in turn leads to the activation of lens calpains and subsequent proteolytic degradation of lens soluble proteins in selenite cataract.
Negative_regulation (loss) of Positive_regulation (accumulation) of Ca2 in lens associated with stress and cataract
8) Confidence 0.29 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2779145 Disease Relevance 0.87 Pain Relevance 0
The protective effect of Drevogenin D could also be attributed to its mitochondrial protective activity by virtue of its ability to prevent oxidative stress and preoxidative damage of mitochondrial membrane, thereby keeping the Ca2+ level normal and preventing calpain activation.
Negative_regulation (preventing) of Positive_regulation (activation) of Ca2 associated with stress
9) Confidence 0.29 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2779145 Disease Relevance 0.15 Pain Relevance 0
Moreover, calmidazolium inhibited capsaicin-induced Ca2+-uptake in sensory neuron cultures with a higher potency than that was determined in TRPV1-NIH3T3 cells (i.e. 0.6 µM vs. ?
Negative_regulation (inhibited) of Positive_regulation (induced) of Ca2 in sensory neuron associated with qutenza and potency
10) Confidence 0.19 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1890308 Disease Relevance 0.13 Pain Relevance 0.43
Chronic incubation with GA resulted in a down-regulation particularly of the NR2B subunit and reduced the NMDA receptor-mediated increase in intracellular Ca2+ (Kölker et al., 2002).
Negative_regulation (reduced) of Positive_regulation (increase) of Ca2 associated with nmda receptor
11) Confidence 0.19 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC3015038 Disease Relevance 0.28 Pain Relevance 0.42
In the present study, we observed that i) the interictal activity was not blocked after Ca2+ elevations in astrocytes were drastically reduced; and ii) synchronous astrocyte Ca2+ elevations were never observed to accompany an interictal discharge in the different models.
Negative_regulation (reduced) of Positive_regulation (elevations) of Ca2 in astrocytes
12) Confidence 0.15 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2854117 Disease Relevance 0.17 Pain Relevance 0.29
The delay of each SIC activated in neurons after astrocyte stimulation with TFLLR was calculated with respect to the peak of the immediately preceding astrocyte Ca2+ increase.
Negative_regulation (preceding) of Positive_regulation (increase) of Ca2 in astrocyte
13) Confidence 0.15 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2854117 Disease Relevance 0.17 Pain Relevance 0.03
It is generally accepted that neuronal degeneration after kainic acid administration is associated with a depletion of ATP levels and accumulation of [Ca2+]i .
Negative_regulation (depletion) of Positive_regulation (accumulation) of Ca2 in neuronal
14) Confidence 0.13 Published 2003 Journal BMC Pharmacol Section Body Doc Link PMC165434 Disease Relevance 0.07 Pain Relevance 0
The elevation of [Ca2+]i is considered to be the primary event of A?
Negative_regulation (event) of Positive_regulation (elevation) of Ca2
15) Confidence 0.13 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2515900 Disease Relevance 0.19 Pain Relevance 0.03
Cholesterol also blocks the increase in [Ca2+]i induced by A?
Negative_regulation (blocks) of Positive_regulation (increase) of Ca2
16) Confidence 0.13 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2515900 Disease Relevance 0.30 Pain Relevance 0
M significantly inhibited the mean increase in [Ca2+]i induced by A?
Negative_regulation (inhibited) of Positive_regulation (increase) of Ca2
17) Confidence 0.13 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2515900 Disease Relevance 0 Pain Relevance 0
Intracellular increase in Ca2+ activity can not be prevented by use of the various pharmacological substances (e.g.
Negative_regulation (prevented) of Positive_regulation (increase) of Ca2
18) Confidence 0.08 Published 2000 Journal Pflugers Arch. Section Abstract Doc Link 10653155 Disease Relevance 0.34 Pain Relevance 0.15
TRPV1 antagonists capsazepine and melatonin inhibited the [Ca2+]i increase evoked by formaldehyde (Fig. 4, C and D) or by capsaicin (Fig. 4, E and F).
Negative_regulation (inhibited) of Positive_regulation (increase) of Ca2 associated with qutenza and antagonist
19) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2858155 Disease Relevance 0.69 Pain Relevance 0.77

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