INT69850

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Context Info
Confidence 0.24
First Reported 1997
Last Reported 1998
Negated 3
Speculated 0
Reported most in Abstract
Documents 2
Total Number 4
Disease Relevance 0
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Pigm)
Pigm (Rattus norvegicus)
Pain Link Frequency Relevance Heat
conotoxin 1 96.64 Very High Very High Very High
Hippocampus 6 95.12 Very High Very High Very High
dexamethasone 1 76.80 Quite High
Spinal cord 5 76.08 Quite High
Kinase C 3 68.92 Quite High
Calcium channel 1 57.76 Quite High
Enkephalin 4 25.00 Low Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment of cells with cycloheximide (a protein synthesis inhibitor; 10 microM) did not affect the forskolin- or PMA-induced increase in proDYN mRNA, but pretreatment with nimodipine (a L-type Ca2+ channel blocker; 2 microM), omega-conotoxin (a N-type Ca2+ channel blocker; 1 microM), or KN-62 (a Ca2+/calmodulin-dependent protein kinase II inhibitor; 5 microM) inhibited induction of proDYN mRNA both by forskolin and PMA.
Neg (not) Regulation (affect) of Positive_regulation (increase) of proDYN mRNA associated with conotoxin
1) Confidence 0.24 Published 1997 Journal Neuropeptides Section Abstract Doc Link 9179864 Disease Relevance 0 Pain Relevance 0.40
The elevations of both proENK and proDYN mRNA levels induced by KA was effectively inhibited by pre-administration of L-ARG (400 mg/kg, i.p.), but was not affected by pre-treatment with L-NAME (200 mg/kg, i.p.).
Neg (not) Regulation (affected) of Positive_regulation (elevations) of proDYN mRNA
2) Confidence 0.03 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9602069 Disease Relevance 0 Pain Relevance 0.09
However, these increases did not show the potentiative effect on KA-induced increases of proENK and proDYN mRNA level.
Regulation (effect) of Positive_regulation (increases) of proDYN mRNA
3) Confidence 0.02 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9602069 Disease Relevance 0 Pain Relevance 0.04
The elevations of both proENK and proDYN mRNA levels induced by KA was effectively inhibited by pre-administration of L-ARG (400 mg/kg, i.p.), but was not affected by pre-treatment with L-NAME (200 mg/kg, i.p.).
Neg (not) Regulation (affected) of Positive_regulation (induced) of proDYN mRNA
4) Confidence 0.01 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9602069 Disease Relevance 0 Pain Relevance 0.08

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