INT69866

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Context Info
Confidence 0.70
First Reported 1997
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 26
Total Number 27
Disease Relevance 16.25
Pain Relevance 8.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Ptgds) transport (Ptgds) Golgi apparatus (Ptgds)
endoplasmic reticulum (Ptgds) lipid metabolic process (Ptgds) cytoplasm (Ptgds)
Anatomy Link Frequency
neutrophil 2
neuronal 1
liver 1
spinal cord 1
MCF-7 1
Ptgds (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 957 100.00 Very High Very High Very High
dexamethasone 32 99.98 Very High Very High Very High
cINOD 69 99.74 Very High Very High Very High
Spinal cord 4 99.40 Very High Very High Very High
allodynia 2 98.12 Very High Very High Very High
TRP channel 4 98.08 Very High Very High Very High
Hyperalgesia 4 97.56 Very High Very High Very High
Paracetamol 3 95.80 Very High Very High Very High
Pain 32 89.56 High High
qutenza 16 83.64 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 1027 100.00 Very High Very High Very High
Alzheimer's Dementia 11 99.84 Very High Very High Very High
Arthropathy 56 99.74 Very High Very High Very High
Disease 30 99.32 Very High Very High Very High
Hypersensitivity 24 99.00 Very High Very High Very High
Neuropathic Pain 2 98.12 Very High Very High Very High
Crystal Associated Disease 330 97.76 Very High Very High Very High
Hyperalgesia 4 97.56 Very High Very High Very High
Injury 16 96.92 Very High Very High Very High
Renal Disease 114 96.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dexamethasone induced L-PGDS gene transcription in run-on assays and activated the mouse L-PGDS gene promoter in transiently transfected cells.
Positive_regulation (activated) of L-PGDS gene associated with dexamethasone
1) Confidence 0.70 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10899920 Disease Relevance 0.17 Pain Relevance 0.37
It can be assumed, that PGD2 biosynthesis under control conditions is mediated via COX-1 and that during inflammation, increased PGD2 is dependent on COX-2.
Positive_regulation (increased) of PGD2 associated with inflammation
2) Confidence 0.67 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18028337 Disease Relevance 0.29 Pain Relevance 0.32
These findings suggest elevation of PGD2 levels as a novel mechanism of action for an anti-inflammatory agent.


Positive_regulation (elevation) of PGD2 associated with inflammation
3) Confidence 0.65 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206389 Disease Relevance 1.20 Pain Relevance 0.48
Here, we report that the level of the mRNA of the receptor for PGD2 (DP1) was increased in AD brains compared with the level in non-AD brains.
Positive_regulation (increased) of PGD2 in brains associated with alzheimer's dementia
4) Confidence 0.62 Published 2007 Journal J. Neuropathol. Exp. Neurol. Section Abstract Doc Link 17549007 Disease Relevance 1.00 Pain Relevance 0
In this study, endotoxin caused a sequential induction of membrane bound prostaglandin E synthase-1 and lipocalin-type PGD synthase (L-PGDS) in the mouse spinal cord.
Positive_regulation (induction) of L-PGDS in spinal cord associated with spinal cord
5) Confidence 0.49 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18028337 Disease Relevance 0.29 Pain Relevance 0.29
In addition to PGD2, CRTH2 can be activated by indomethacin, a nonselective cyclooxygenase inhibitor and widely used nonsteroidal anti-inflammatory drug (NSAID).
Positive_regulation (activated) of PGD2 associated with inflammation and cinod
6) Confidence 0.48 Published 2005 Journal Mol. Pharmacol. Section Abstract Doc Link 15563582 Disease Relevance 0.46 Pain Relevance 0.39
might be part of the mechanism for PGD2 stimulation in this model.
Positive_regulation (stimulation) of PGD2
7) Confidence 0.47 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206389 Disease Relevance 0.62 Pain Relevance 0.28
The mode of action of this mixture seems to be owing to both a reduction of pro-inflammatory factors and a stimulation of at least one potentially anti-inflammatory factor, PGD2.
Positive_regulation (stimulation) of PGD2 associated with inflammation
8) Confidence 0.44 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206389 Disease Relevance 1.19 Pain Relevance 0.38
These results support a need for further studies of the efficacy of these extracts in the treatment of inflammatory arthropathies and suggest elevation of PGD2 levels as a novel mechanism for an anti-inflammatory agent.



Positive_regulation (elevation) of PGD2 associated with inflammation and arthropathy
9) Confidence 0.44 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC2206389 Disease Relevance 0.87 Pain Relevance 0.34
Preliminary data suggest that raised h-PGDS mRNA levels might be part of the mechanism underlying the elevation of PGD2 levels.
Positive_regulation (elevation) of PGD2
10) Confidence 0.44 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206389 Disease Relevance 0.97 Pain Relevance 0.49
To our knowledge, elevation of PGD2 levels has not been described as the effect of an anti-inflammatory agent.
Positive_regulation (elevation) of PGD2 associated with inflammation
11) Confidence 0.44 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206389 Disease Relevance 1.14 Pain Relevance 0.47
These results suggest elevation of PGD2 levels as a novel mechanism for an anti-inflammatory agent.
Positive_regulation (elevation) of PGD2 associated with inflammation
12) Confidence 0.44 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206389 Disease Relevance 0.88 Pain Relevance 0.45
The absolute levels of PGD2 and PGD3 that are generated in our assay system, and thus the ratio of their abundance, are not easily assessed.
Positive_regulation (generated) of PGD2
13) Confidence 0.42 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2718617 Disease Relevance 0 Pain Relevance 0.04
By northern and western assays we show that the synthetic glucocorticoid dexamethasone, an inhibitor of PG production in most tissues, induces L-PGDS mRNA and protein in a dose- and time-dependent fashion in mouse neuronal GT1-7 cells.
Positive_regulation (induces) of L-PGDS in neuronal associated with dexamethasone
14) Confidence 0.41 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10899920 Disease Relevance 0.16 Pain Relevance 0.32
Accordingly, dexamethasone increases cellular L-PGDS enzymatic activity.
Positive_regulation (increases) of L-PGDS associated with dexamethasone
15) Confidence 0.41 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10899920 Disease Relevance 0.17 Pain Relevance 0.37
Structural determinants of arylacetic acid nonsteroidal anti-inflammatory drugs necessary for binding and activation of the prostaglandin D2 receptor CRTH2.
Positive_regulation (activation) of prostaglandin D2 associated with inflammation and cinod
16) Confidence 0.39 Published 2005 Journal Mol. Pharmacol. Section Title Doc Link 15563582 Disease Relevance 0.45 Pain Relevance 0.42
Reduction of urate crystal-induced inflammation by root extracts from traditional oriental medicinal plants: elevation of prostaglandin D2 levels

Dried roots of the plants Acanthopanax senticosus, Angelica sinensis and Scutellaria baicalensis are used in traditional oriental medicine and reportedly possess anti-inflammatory properties.

Positive_regulation (elevation) of prostaglandin D2 associated with inflammation
17) Confidence 0.38 Published 2007 Journal Arthritis Res Ther Section Title Doc Link PMC2206389 Disease Relevance 0.73 Pain Relevance 0.25
Increase in the level of prostaglandin D2 by treatment with the root extracts
Positive_regulation (Increase) of prostaglandin D2
18) Confidence 0.38 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206389 Disease Relevance 1.12 Pain Relevance 0.32
Thus, the root extracts diminished MSU crystal-induced inflammation by reducing neutrophil recruitment and expression of pro-inflammatory factors and increasing the level of the potentially anti-inflammatory PGD2.
Positive_regulation (increasing) of PGD2 in neutrophil associated with inflammation and crystal associated disease
19) Confidence 0.38 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC2206389 Disease Relevance 0.80 Pain Relevance 0.29
A mixture of root extracts from oriental medicinal plants diminished MSU crystal-induced inflammation by reducing neutrophil recruitment and expression of pro-inflammatory factors and increasing the level of the potentially anti-inflammatory PGD2.
Positive_regulation (increasing) of PGD2 in neutrophil associated with inflammation and crystal associated disease
20) Confidence 0.38 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206389 Disease Relevance 0.95 Pain Relevance 0.52

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