INT69867

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Context Info
Confidence 0.75
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 36
Total Number 38
Disease Relevance 24.54
Pain Relevance 10.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Mip) plasma membrane (Mip) transmembrane transport (Mip)
Anatomy Link Frequency
macrophages 1
diaphragm 1
lens 1
monocyte 1
neurons 1
Mip (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 753 100.00 Very High Very High Very High
Inflammation 544 100.00 Very High Very High Very High
cytokine 467 100.00 Very High Very High Very High
dorsal root ganglion 26 99.04 Very High Very High Very High
qutenza 31 94.76 High High
rheumatoid arthritis 211 93.68 High High
Inflammatory response 58 93.12 High High
Pain 21 89.12 High High
antagonist 22 87.28 High High
Arthritis 66 87.00 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 591 100.00 Very High Very High Very High
Candida Infection 411 99.72 Very High Very High Very High
Sprains And Strains 163 99.64 Very High Very High Very High
Infection 374 99.62 Very High Very High Very High
Nociception 31 99.52 Very High Very High Very High
Ganglion Cysts 26 99.04 Very High Very High Very High
Metaplasia 9 99.04 Very High Very High Very High
Endotoxemia 126 99.00 Very High Very High Very High
Sepsis 367 98.84 Very High Very High Very High
Cataract 3 98.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, under control conditions, the baseline expression levels of both RANTES and MIP-1?
Gene_expression (expression) of MIP
1) Confidence 0.75 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2676322 Disease Relevance 0.32 Pain Relevance 0.13
Here we sought to study the local expression and
                             molecular regulation of the chemokines, regulated upon activation
                             normal T cell expressed and secreted (RANTES) and macrophage
                             inflammatory protein (MIP)-1?
Gene_expression (expressed) of MIP in T cell associated with chemokine and inflammation
2) Confidence 0.75 Published 2009 Journal Mediators of Inflammation Section Abstract Doc Link PMC2676322 Disease Relevance 0.82 Pain Relevance 0.22
The expression of MIP-1?
Gene_expression (expression) of MIP
3) Confidence 0.75 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2127221 Disease Relevance 0.05 Pain Relevance 0.10
The major findings of our study can be summarized as follows: (1) diaphragmatic CCR1 gene expression is upregulated in response to acute endotoxemia; (2) both acute endotoxemia and Pseudomonas lung infection lead to increased expression of the CCR1 ligands, RANTES and MIP-1?
Gene_expression (expression) of MIP in lung associated with endotoxemia and infection
4) Confidence 0.75 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2676322 Disease Relevance 0.73 Pain Relevance 0.22
By contrast, levels of IL-6 and MIP-2?
Gene_expression (levels) of MIP
5) Confidence 0.75 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1088279 Disease Relevance 0.90 Pain Relevance 0.22
We next sought to evaluate whether the observed upregulation of CCRs in the septic diaphragm and TA is associated with altered expression of their cognate ligands, RANTES and MIP-1?
Gene_expression (expression) of MIP in diaphragm
6) Confidence 0.75 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2676322 Disease Relevance 0.09 Pain Relevance 0.07
For example, in the mdx mouse, a murine model of Duchenne muscular dystrophy, the diaphragm exhibits a pronounced infiltration by macrophages and lymphocyctes, which parallels a marked overexpression of RANTES and MIP-1?
Gene_expression (overexpression) of MIP in macrophages associated with muscular dystrophy
7) Confidence 0.65 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2676322 Disease Relevance 0.91 Pain Relevance 0.29
Figure 3 shows that both RANTES and MIP-1?
Gene_expression (shows) of MIP
8) Confidence 0.65 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2676322 Disease Relevance 0.41 Pain Relevance 0.18
Figure 2 shows that the overall patterns of RANTES and MIP-1?
Gene_expression (overall) of MIP
9) Confidence 0.65 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2676322 Disease Relevance 0.08 Pain Relevance 0.08
It has been found that both NK cells and CD8+ T cells use RANTES and MIP-1?
Gene_expression (use) of MIP in NK cells
10) Confidence 0.65 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2676322 Disease Relevance 0.59 Pain Relevance 0.45
, IL-17A, and GM-CSF,, and chemokines such as eotaxin, MIP-1?
Gene_expression (chemokines) of MIP associated with chemokine
11) Confidence 0.65 Published 2009 Journal Respir Res Section Body Doc Link PMC2731726 Disease Relevance 1.47 Pain Relevance 0.31
Constitutive
                             expression levels of RANTES and MIP-1?
Gene_expression (expression) of MIP
12) Confidence 0.65 Published 2009 Journal Mediators of Inflammation Section Abstract Doc Link PMC2676322 Disease Relevance 0.81 Pain Relevance 0.21
Ribonuclease protection assays were performed to quantify RANTES and MIP-1?
Gene_expression (quantify) of MIP
13) Confidence 0.65 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2676322 Disease Relevance 0.17 Pain Relevance 0.16
Having shown that both RANTES and MIP-1?
Gene_expression (shown) of MIP
14) Confidence 0.65 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2676322 Disease Relevance 0.42 Pain Relevance 0.20
Pulmonary exposure to CSBG elevated the levels of MIP-1?
Gene_expression (levels) of MIP associated with candida infection
15) Confidence 0.65 Published 2009 Journal Respir Res Section Body Doc Link PMC2731726 Disease Relevance 1.37 Pain Relevance 0.31
Protein levels of CCL3 (MIP-?)
Gene_expression (levels) of MIP
16) Confidence 0.65 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526593 Disease Relevance 0.49 Pain Relevance 0.34
The observation that an intact RANK signaling pathway is indispensable for the osteoclastogenic effect of MIP-1?
Gene_expression (effect) of MIP
17) Confidence 0.65 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1924519 Disease Relevance 1.27 Pain Relevance 0.03
With regard to targeting MIP-1?
Gene_expression (targeting) of MIP
18) Confidence 0.65 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1924519 Disease Relevance 1.06 Pain Relevance 0.08
Levels of MIP-1?
Gene_expression (Levels) of MIP
19) Confidence 0.65 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2430555 Disease Relevance 1.05 Pain Relevance 0.67
Also, chemokine profiles in the acute phase were different, with high levels of RANTES found in mice infected either both strains, but with higher levels of cardiac MIG, MCP-1, and MIP-1?
Gene_expression (levels) of MIP associated with chemokine and sprains and strains
20) Confidence 0.65 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2852613 Disease Relevance 0.72 Pain Relevance 0.21

General Comments

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