INT69871

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Context Info
Confidence 0.36
First Reported 1997
Last Reported 1997
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 1.07

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pigmentation (ASIP, TYRP1) signal transduction (ASIP) generation of precursor metabolites and energy (ASIP)
extracellular space (ASIP) extracellular region (ASIP) cell-cell signaling (ASIP)
ASIP (Homo sapiens)
TYRP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 14 88.32 High High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the absence of exogenous alpha-MSH, ASIP inhibited basal levels of tyrosinase activity and cell proliferation and reduced the level of immunoreactive tyrosinase-related protein-1 (TRP-1) without significantly altering the level of immunoreactive tyrosinase.
ASIP Negative_regulation (reduced) of TRP-1
1) Confidence 0.36 Published 1997 Journal J. Invest. Dermatol. Section Abstract Doc Link 9182807 Disease Relevance 0 Pain Relevance 0.54
In the absence of exogenous alpha-MSH, ASIP inhibited basal levels of tyrosinase activity and cell proliferation and reduced the level of immunoreactive tyrosinase-related protein-1 (TRP-1) without significantly altering the level of immunoreactive tyrosinase.
ASIP Negative_regulation (reduced) of tyrosinase-related protein-1
2) Confidence 0.26 Published 1997 Journal J. Invest. Dermatol. Section Abstract Doc Link 9182807 Disease Relevance 0 Pain Relevance 0.53

General Comments

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