INT69872

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Context Info
Confidence 0.54
First Reported 1997
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 52
Total Number 55
Disease Relevance 8.87
Pain Relevance 18.30

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small molecule metabolic process (POMC) cell-cell signaling (POMC) cytoplasm (POMC)
signal transducer activity (MC1R) pigmentation (MC1R) extracellular space (POMC)
Anatomy Link Frequency
melanocytes 26
pigmentation 8
plasma 4
MC1R (Homo sapiens)
POMC (Homo sapiens)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 549 100.00 Very High Very High Very High
Inflammation 16 97.92 Very High Very High Very High
Inflammatory response 5 97.04 Very High Very High Very High
Potency 10 96.36 Very High Very High Very High
opiate 6 92.80 High High
antagonist 5 90.56 High High
agonist 14 80.72 Quite High
adenocard 2 32.72 Quite Low
addiction 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 15 99.64 Very High Very High Very High
Apoptosis 4 99.12 Very High Very High Very High
INFLAMMATION 21 97.92 Very High Very High Very High
Melanoma 364 94.96 High High
Diabetes Mellitus 5 89.24 High High
Skin Cancer 32 87.92 High High
Necrosis 5 87.32 High High
Cancer 35 86.96 High High
Sunburn 28 82.32 Quite High
Malignant Neoplastic Disease 16 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The synthesis of eumelanin is stimulated by the binding of alpha-melanotropin (alpha-melanocyte-stimulating hormone) to the functional melanocortin 1 receptor (MC1R) expressed on melanocytes.
MC1R Binding (binding) of alpha-melanocyte-stimulating hormone in melanocyte associated with melanocortin 1 receptor
1) Confidence 0.54 Published 2002 Journal J. Cell. Sci. Section Abstract Doc Link 12006619 Disease Relevance 0.34 Pain Relevance 0.46
The synthesis of eumelanin is stimulated by the binding of alpha-melanotropin (alpha-melanocyte-stimulating hormone) to the functional melanocortin 1 receptor (MC1R) expressed on melanocytes.
melanocortin 1 receptor Binding (binding) of alpha-melanocyte-stimulating hormone in melanocyte associated with melanocortin 1 receptor
2) Confidence 0.54 Published 2002 Journal J. Cell. Sci. Section Abstract Doc Link 12006619 Disease Relevance 0.34 Pain Relevance 0.45
-MSH, which binds to MC1R, is involved in anti-apoptotic DNA repair and anti-inflammatory pathways (53–56).
MC1R Binding (binds) of MSH associated with inflammation, melanocortin 1 receptor and apoptosis
3) Confidence 0.54 Published 2010 Journal JNCI Journal of the National Cancer Institute Section Body Doc Link PMC2957428 Disease Relevance 0.76 Pain Relevance 0.57
Alpha melanocyte-stimulating hormone (MSH) and related proopiomelanocortin-derived (POMC) peptides bind to the melanocortin 1 receptor (MC1-R) of mammalian melanocytes and stimulate proliferation and melanogenesis.
melanocortin 1 receptor Binding (bind) of MSH in melanocytes associated with melanocortin 1 receptor
4) Confidence 0.53 Published 1999 Journal Cell. Mol. Biol. (Noisy-le-grand) Section Abstract Doc Link 10644013 Disease Relevance 0.35 Pain Relevance 0.10
Alpha melanocyte-stimulating hormone (MSH) and related proopiomelanocortin-derived (POMC) peptides bind to the melanocortin 1 receptor (MC1-R) of mammalian melanocytes and stimulate proliferation and melanogenesis.
MC1-R Binding (bind) of MSH in melanocytes associated with melanocortin 1 receptor
5) Confidence 0.53 Published 1999 Journal Cell. Mol. Biol. (Noisy-le-grand) Section Abstract Doc Link 10644013 Disease Relevance 0.35 Pain Relevance 0.10
Alpha melanocyte-stimulating hormone (MSH) and related proopiomelanocortin-derived (POMC) peptides bind to the melanocortin 1 receptor (MC1-R) of mammalian melanocytes and stimulate proliferation and melanogenesis.
MC1-R Binding (bind) of Alpha melanocyte-stimulating hormone in melanocytes associated with melanocortin 1 receptor
6) Confidence 0.53 Published 1999 Journal Cell. Mol. Biol. (Noisy-le-grand) Section Abstract Doc Link 10644013 Disease Relevance 0.35 Pain Relevance 0.10
Alpha melanocyte-stimulating hormone (MSH) and related proopiomelanocortin-derived (POMC) peptides bind to the melanocortin 1 receptor (MC1-R) of mammalian melanocytes and stimulate proliferation and melanogenesis.
melanocortin 1 receptor Binding (bind) of Alpha melanocyte-stimulating hormone in melanocytes associated with melanocortin 1 receptor
7) Confidence 0.53 Published 1999 Journal Cell. Mol. Biol. (Noisy-le-grand) Section Abstract Doc Link 10644013 Disease Relevance 0.35 Pain Relevance 0.10
ACTH and alpha-MSH in association with their processing enzymes and MC-1R are expressed in human follicular melanocytes at the message level in vitro and at the protein level both in situ and in vitro.
MC-1R Binding (association) of ACTH in melanocytes
8) Confidence 0.47 Published 2005 Journal Endocrinology Section Abstract Doc Link 15498881 Disease Relevance 0 Pain Relevance 0.22
Its effect on pigmentation is achieved by antagonizing the binding of alpha-melanocyte stimulating hormone (alpha-MSH) to melanocortin 1 receptor (Mc1r), switching melanin synthesis from eumelanin (black/brown) to phaeomelanin (red/yellow).
melanocortin 1 receptor Binding (binding) of alpha-MSH in melanocyte associated with melanocortin 1 receptor
9) Confidence 0.43 Published 2002 Journal Pigment Cell Res. Section Abstract Doc Link 11837451 Disease Relevance 0.22 Pain Relevance 0.26
Its effect on pigmentation is achieved by antagonizing the binding of alpha-melanocyte stimulating hormone (alpha-MSH) to melanocortin 1 receptor (Mc1r), switching melanin synthesis from eumelanin (black/brown) to phaeomelanin (red/yellow).
Mc1r Binding (binding) of alpha-MSH in melanocyte associated with melanocortin 1 receptor
10) Confidence 0.43 Published 2002 Journal Pigment Cell Res. Section Abstract Doc Link 11837451 Disease Relevance 0.22 Pain Relevance 0.26
The yellow coat colour is the result of agouti chronically antagonizing the binding of alpha-MSH to Mc1r and the obese phenotype results from agouti protein antagonizing the binding of alpha-MSH to Mc3r and/or Mc4r.
Mc1r Binding (binding) of alpha-MSH associated with melanocortin 1 receptor and obesity
11) Confidence 0.43 Published 2002 Journal Pigment Cell Res. Section Abstract Doc Link 11837451 Disease Relevance 0.35 Pain Relevance 0.26
Its effect on pigmentation is achieved by antagonizing the binding of alpha-melanocyte stimulating hormone (alpha-MSH) to melanocortin 1 receptor (Mc1r), switching melanin synthesis from eumelanin (black/brown) to phaeomelanin (red/yellow).
Mc1r Binding (binding) of alpha-melanocyte stimulating hormone in melanocyte associated with melanocortin 1 receptor
12) Confidence 0.43 Published 2002 Journal Pigment Cell Res. Section Abstract Doc Link 11837451 Disease Relevance 0.22 Pain Relevance 0.26
Its effect on pigmentation is achieved by antagonizing the binding of alpha-melanocyte stimulating hormone (alpha-MSH) to melanocortin 1 receptor (Mc1r), switching melanin synthesis from eumelanin (black/brown) to phaeomelanin (red/yellow).
melanocortin 1 receptor Binding (binding) of alpha-melanocyte stimulating hormone in melanocyte associated with melanocortin 1 receptor
13) Confidence 0.43 Published 2002 Journal Pigment Cell Res. Section Abstract Doc Link 11837451 Disease Relevance 0.22 Pain Relevance 0.26
Alpha-melanocyte stimulating hormone (alpha-MSH) binds to melanocortin-1 receptor (MC1R) on melanocytes to stimulate pigmentation and modulate various cutaneous inflammatory responses.
MC1R Binding (binds) of alpha-MSH in pigmentation associated with inflammatory response and melanocortin 1 receptor
14) Confidence 0.43 Published 2009 Journal Photochem. Photobiol. Section Abstract Doc Link 19656324 Disease Relevance 0.31 Pain Relevance 0.57
Alpha-melanocyte stimulating hormone (alpha-MSH) binds to melanocortin-1 receptor (MC1R) on melanocytes to stimulate pigmentation and modulate various cutaneous inflammatory responses.
MC1R Binding (binds) of Alpha-melanocyte stimulating hormone in pigmentation associated with inflammatory response and melanocortin 1 receptor
15) Confidence 0.43 Published 2009 Journal Photochem. Photobiol. Section Abstract Doc Link 19656324 Disease Relevance 0.31 Pain Relevance 0.57
Alpha-melanocyte stimulating hormone (alpha-MSH) binds to melanocortin-1 receptor (MC1R) on melanocytes to stimulate pigmentation and modulate various cutaneous inflammatory responses.
melanocortin-1 receptor Binding (binds) of Alpha-melanocyte stimulating hormone in pigmentation associated with inflammatory response and melanocortin 1 receptor
16) Confidence 0.43 Published 2009 Journal Photochem. Photobiol. Section Abstract Doc Link 19656324 Disease Relevance 0.30 Pain Relevance 0.57
Alpha-melanocyte stimulating hormone (alpha-MSH) binds to melanocortin-1 receptor (MC1R) on melanocytes to stimulate pigmentation and modulate various cutaneous inflammatory responses.
melanocortin-1 receptor Binding (binds) of alpha-MSH in pigmentation associated with inflammatory response and melanocortin 1 receptor
17) Confidence 0.43 Published 2009 Journal Photochem. Photobiol. Section Abstract Doc Link 19656324 Disease Relevance 0.30 Pain Relevance 0.57
ACTH and alpha-MSH bind to the melanocortin-1 receptor (MC-1-R) on the plasma membrane and activate the signalling pathway predominantly coupled to production of cAMP, and in some cell lines raising intracellular calcium levels.
melanocortin-1 receptor Binding (bind) of ACTH in plasma associated with melanocortin 1 receptor
18) Confidence 0.41 Published 2006 Journal Cell. Mol. Biol. (Noisy-le-grand) Section Abstract Doc Link 16914090 Disease Relevance 0 Pain Relevance 0.10
Interestingly, alpha-MSH is predicted to only have a kinetic effect on the MC-1-R and beta-MSH has even a weaker affinity for the MC-1-R than alpha-MSH.
MC-1-R Binding (affinity) of beta-MSH
19) Confidence 0.41 Published 2006 Journal Cell. Mol. Biol. (Noisy-le-grand) Section Abstract Doc Link 16914090 Disease Relevance 0 Pain Relevance 0.06
ACTH and alpha-MSH bind to the melanocortin-1 receptor (MC-1-R) on the plasma membrane and activate the signalling pathway predominantly coupled to production of cAMP, and in some cell lines raising intracellular calcium levels.
melanocortin-1 receptor Binding (bind) of alpha-MSH in plasma associated with melanocortin 1 receptor
20) Confidence 0.41 Published 2006 Journal Cell. Mol. Biol. (Noisy-le-grand) Section Abstract Doc Link 16914090 Disease Relevance 0 Pain Relevance 0.10

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