INT69875

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Context Info
Confidence 0.39
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.37
Pain Relevance 1.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (MC1R) plasma membrane (MC1R) signal transducer activity (MC1R)
Anatomy Link Frequency
melanocytes 2
MC1R (Homo sapiens)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 165 100.00 Very High Very High Very High
addiction 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Melanoma 154 75.68 Quite High
Nevus 31 24.88 Low Low
Sunburn 14 15.12 Low Low
Cancer 11 5.00 Very Low Very Low Very Low
Burns 7 5.00 Very Low Very Low Very Low
Disease 5 5.00 Very Low Very Low Very Low
Skin Cancer 4 5.00 Very Low Very Low Very Low
Death 3 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low
Retinoblastoma 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In mouse follicular melanocytes, the switch between eumelanin and pheomelanin synthesis is regulated by the extension locus, which encodes the melanocortin-1 receptor (MC1R) and the agouti locus, which encodes a novel paracrine-signaling molecule that inhibits binding of melanocortins to the MC1R.
Negative_regulation (inhibits) of MC1R Binding (binding) of in melanocytes associated with melanocortin 1 receptor
1) Confidence 0.39 Published 1997 Journal J. Invest. Dermatol. Section Abstract Doc Link 9182807 Disease Relevance 0 Pain Relevance 0.47
Although the V92M variant was reported to have an ability to increase the cylic AMP levels similar to that of the wild-type MC1R (38,39), it was found to have a reduced affinity for the MC1R ligand, ?
Negative_regulation (reduced) of MC1R Binding (affinity) of associated with melanocortin 1 receptor
2) Confidence 0.37 Published 2010 Journal JNCI Journal of the National Cancer Institute Section Body Doc Link PMC2957428 Disease Relevance 0.37 Pain Relevance 0.79

General Comments

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