INT69876

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Context Info
Confidence 0.58
First Reported 1997
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 147
Total Number 149
Disease Relevance 89.81
Pain Relevance 55.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nfkb1) signal transduction (Nfkb1) mitochondrion (Nfkb1)
nucleus (Nfkb1) DNA binding (Nfkb1) nucleic acid binding transcription factor activity (Nfkb1)
Anatomy Link Frequency
neutrophil 8
macrophages 5
lymphocytes 5
nucleus 4
lung 3
Nfkb1 (Mus musculus)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 55 100.00 Very High Very High Very High
COX2 30 100.00 Very High Very High Very High
excitatory amino acid 1 100.00 Very High Very High Very High
Paracetamol 128 99.98 Very High Very High Very High
Inflammatory response 65 99.92 Very High Very High Very High
aspirin 134 99.84 Very High Very High Very High
cINOD 133 99.84 Very High Very High Very High
intrathecal 2 99.84 Very High Very High Very High
Inflammation 1099 99.82 Very High Very High Very High
Inflammatory mediators 28 99.82 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 347 100.00 Very High Very High Very High
Targeted Disruption 116 100.00 Very High Very High Very High
Stress 76 100.00 Very High Very High Very High
Necrosis 52 100.00 Very High Very High Very High
Frailty 18 100.00 Very High Very High Very High
Repression 18 100.00 Very High Very High Very High
Apoptosis 145 99.96 Very High Very High Very High
Injury 94 99.92 Very High Very High Very High
Ovarian Cancer 10 99.92 Very High Very High Very High
INFLAMMATION 1043 99.82 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Aspirin may also protect against Hodgkin's lymphoma by inhibiting transcription factor nuclear factor kappaB (NF-kappaB), which is necessary for immune function and the survival of Hodgkin's lymphoma cells.
Negative_regulation (inhibiting) of transcription factor nuclear factor kappaB associated with lymphatic system cancer
1) Confidence 0.58 Published 2004 Journal J. Natl. Cancer Inst. Section Abstract Doc Link 14970279 Disease Relevance 0.45 Pain Relevance 0.45
Thus, agents that suppress NF-kappaB activity should be useful as adjuvants to cytotoxic cancer therapy.
Negative_regulation (suppress) of NF-kappaB associated with cancer
2) Confidence 0.58 Published 2006 Journal Integr Cancer Ther Section Abstract Doc Link 16880431 Disease Relevance 0.67 Pain Relevance 0.17
A toxic dose of acetaminophen (APAP) reduces the activity of NF-kappaB in mouse liver.
Negative_regulation (reduces) of NF-kappaB in liver associated with paracetamol
3) Confidence 0.58 Published 2000 Journal Toxicol. Sci. Section Abstract Doc Link 10828269 Disease Relevance 0.17 Pain Relevance 0.59
Suppression of the nuclear factor-kappaB activation pathway by spice-derived phytochemicals: reasoning for seasoning.
Negative_regulation (Suppression) of nuclear factor-kappaB
4) Confidence 0.58 Published 2004 Journal Ann. N. Y. Acad. Sci. Section Title Doc Link 15659827 Disease Relevance 1.42 Pain Relevance 0.30
Dexamethasone (3-30 mg/kg, i.p.), which, like aspirin and salicylate, has been reported to inhibit the transcription factor NF-kappaB, was also ineffective.
Negative_regulation (inhibit) of NF-kappaB associated with aspirin and dexamethasone
5) Confidence 0.57 Published 1998 Journal J. Neurochem. Section Abstract Doc Link 9751197 Disease Relevance 0.22 Pain Relevance 0.71
Nuclear extracts of purified, aspirin-treated DC revealed a decreased NF-kappaB DNA-binding activity, whereas Ab supershift analysis indicated that aspirin targeted primarily NF-kappaB p50.
Negative_regulation (decreased) of NF-kappaB associated with aspirin
6) Confidence 0.57 Published 2001 Journal J. Immunol. Section Abstract Doc Link 11390449 Disease Relevance 0.08 Pain Relevance 0.42
This occurred at the transcriptional level, since the gingerol compounds decreased LPS-induced IkappaB-alpha degradation, prevented nuclear translocation of NF-kappaB p65 and reduced NF-kappaB activity in a concentration-dependent manner.
Negative_regulation (reduced) of NF-kappaB
7) Confidence 0.57 Published 2006 Journal Planta Med. Section Abstract Doc Link 16732525 Disease Relevance 0.17 Pain Relevance 0.17
S. pneumoniae infection resulted in a significant induction of NF-kappaB activity only in TLR9 stably transfected HEK 293 cells, but not in TLR2 and TLR4 transfected HEK 293 cells, and morphine treatment inhibited S. pneumoniae-induced NF-kappaB activity in these cells.
Negative_regulation (inhibited) of NF-kappaB associated with infection and morphine
8) Confidence 0.57 Published 2008 Journal J. Immunol. Section Abstract Doc Link 18292587 Disease Relevance 0.73 Pain Relevance 0.59
Hence, NF-kappaB has become a major target in drug discovery, and several natural and synthetic compounds have been investigated for their potential to inhibit NF-kappaB.
Spec (investigated) Negative_regulation (inhibit) of NF-kappaB
9) Confidence 0.57 Published 2008 Journal Biochem. Pharmacol. Section Abstract Doc Link 17919455 Disease Relevance 0.36 Pain Relevance 0.09
While RNAi depletion of Keap1 led to reduced toxicity following exposure to DNCB, depletion of Nrf2 and NF-kappaB augmented toxicity.
Negative_regulation (depletion) of NF-kappaB associated with toxicity
10) Confidence 0.56 Published 2010 Journal Biochem. Pharmacol. Section Abstract Doc Link 20416283 Disease Relevance 0.47 Pain Relevance 0.11
Interestingly, increased Nrf2 caused by Keap1 depletion was reversed by co-depletion of NF-kappaB.
Negative_regulation (depletion) of NF-kappaB
11) Confidence 0.56 Published 2010 Journal Biochem. Pharmacol. Section Abstract Doc Link 20416283 Disease Relevance 0.40 Pain Relevance 0.10
However, in contrast to NAC pretreatment, the loss of p50 had no effect on APAP-induced hepatotoxicity.
Negative_regulation (loss) of p50 associated with paracetamol and hepatotoxicity
12) Confidence 0.51 Published 2006 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 16081117 Disease Relevance 0.90 Pain Relevance 0.79
As observed with NAC pretreatment, the loss of NF-kappaB p50 was associated with decreased ability of APAP to upregulate TNFalpha, KC/gro, and IL-10 expression and increased expression of IL-4 and TGFbeta.
Negative_regulation (loss) of p50 associated with paracetamol
13) Confidence 0.51 Published 2006 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 16081117 Disease Relevance 1.10 Pain Relevance 0.96
Aspirin-induced proteasomal malfunction might be responsible, at least in part, for the down-regulation of NF-kappaB activity and neurite outgrowth.
Negative_regulation (down-regulation) of NF-kappaB in neurite associated with aspirin
14) Confidence 0.51 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16880202 Disease Relevance 0.58 Pain Relevance 0.35
We tested this hypothesis by generating double mutant mice deficient in both p50 and IL-6, and comparing neutrophil recruitment in double mutants and mice deficient in IL-6 alone. p50 deficiency decreased neutrophil recruitment in the absence of IL-6.
Negative_regulation (deficient) of p50 in neutrophil
15) Confidence 0.50 Published 2004 Journal BMC Immunol Section Body Doc Link PMC449706 Disease Relevance 0.27 Pain Relevance 0.21
The phytoestrogen had immunomodulatory and anti-inflammatory activities as it reduced peripheral and central nuclear factor-kappaB, nitric oxide system and pro-inflammatory cytokine over-activation.
Negative_regulation (reduced) of nuclear factor-kappaB associated with inflammation and cytokine
16) Confidence 0.49 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18691380 Disease Relevance 1.09 Pain Relevance 0.79
Taken together, our data indicate that the anti-inflammatory and antinociceptive properties of siegeskaurolic acid may be due to iNOS, COX-2 and TNF-alpha inhibition via the down-regulation of NF-kappaB binding activity.
Negative_regulation (down-regulation) of NF-kappaB associated with inflammation and antinociceptive
17) Confidence 0.46 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17207792 Disease Relevance 0.44 Pain Relevance 0.22
Anti-inflammatory activities of ent-16alphaH,17-hydroxy-kauran-19-oic acid isolated from the roots of Siegesbeckia pubescens are due to the inhibition of iNOS and COX-2 expression in RAW 264.7 macrophages via NF-kappaB inactivation.
Negative_regulation (inactivation) of NF-kappaB in macrophages associated with inflammation and analgesic
18) Confidence 0.46 Published 2007 Journal Eur. J. Pharmacol. Section Title Doc Link 17207792 Disease Relevance 0.56 Pain Relevance 0.35
Furthermore, siegeskaurolic acid inhibited the nuclear factor-kappaB (NF-kappaB) activation induced by LPS, and this was associated with the prevention of inhibitor kappaB degradation (I kappaB), and subsequently with decreased nuclear p65 and p50 protein levels.
Negative_regulation (decreased) of p50
19) Confidence 0.46 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17207792 Disease Relevance 0.38 Pain Relevance 0.23
The induction of ANXA1 by glucocorticoids was proportional to their anti-inflammatory potency, as was the suppression of NF-kappaB activity, which was accompanied by enhanced apoptosis and inhibition of cell growth mediated by changes in NF-kappaB-dependent cell signaling.
Negative_regulation (suppression) of NF-kappaB associated with inflammation, apoptosis and potency
20) Confidence 0.45 Published 2010 Journal Cancer Res. Section Abstract Doc Link 20215502 Disease Relevance 0.88 Pain Relevance 0.47

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