INT69877

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Context Info
Confidence 0.68
First Reported 1997
Last Reported 2010
Negated 3
Speculated 1
Reported most in Abstract
Documents 53
Total Number 54
Disease Relevance 31.44
Pain Relevance 20.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nfkb1) signal transduction (Nfkb1) mitochondrion (Nfkb1)
nucleus (Nfkb1) DNA binding (Nfkb1) nucleic acid binding transcription factor activity (Nfkb1)
Anatomy Link Frequency
neutrophil 9
DRG 6
lung 5
liver 4
spinal cord 4
Nfkb1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 226 100.00 Very High Very High Very High
Inflammatory response 52 100.00 Very High Very High Very High
aspirin 14 100.00 Very High Very High Very High
Spinal cord 9 100.00 Very High Very High Very High
Endogenous opioid 2 100.00 Very High Very High Very High
agonist 88 99.92 Very High Very High Very High
Hyperalgesia 12 99.90 Very High Very High Very High
Inflammation 355 99.86 Very High Very High Very High
Pain 12 99.86 Very High Very High Very High
COX2 9 99.86 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 409 100.00 Very High Very High Very High
Hemophilus Infection 178 99.98 Very High Very High Very High
Infection 73 99.98 Very High Very High Very High
Hepatitis C Virus Infection 24 99.96 Very High Very High Very High
Hyperalgesia 18 99.90 Very High Very High Very High
Apoptosis 232 99.76 Very High Very High Very High
Fibrosis 18 99.40 Very High Very High Very High
Lung Injury 4 99.14 Very High Very High Very High
Neuropathic Pain 19 99.12 Very High Very High Very High
Dengue 3 99.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treatment of Hepa 1-6 cells with H(2)O(2) was sufficient for NF-kappaB activation and IkappaBalpha degradation, and APAP was able to block both of these events.
Positive_regulation (sufficient) of Positive_regulation (activation) of NF-kappaB in Hepa 1-6 associated with paracetamol
1) Confidence 0.68 Published 2000 Journal Toxicol. Sci. Section Abstract Doc Link 10828269 Disease Relevance 0.16 Pain Relevance 0.90
Clonidine also significantly enhanced LPS-induced NF-kappaB activation by enhancing the nuclear translocation of NF-kappaB as well as increasing the NF-kappaB-DNA binding activity.
Positive_regulation (induced) of Positive_regulation (activation) of NF-kappaB
2) Confidence 0.59 Published 2008 Journal J. Surg. Res. Section Body Doc Link 18262561 Disease Relevance 0 Pain Relevance 0
Furthermore, siegeskaurolic acid inhibited the nuclear factor-kappaB (NF-kappaB) activation induced by LPS, and this was associated with the prevention of inhibitor kappaB degradation (I kappaB), and subsequently with decreased nuclear p65 and p50 protein levels.
Positive_regulation (induced) of Positive_regulation (activation) of NF-kappaB
3) Confidence 0.55 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17207792 Disease Relevance 0.45 Pain Relevance 0.26
By contrast, islets retain their immunoprotective status and activate nuclear factor-kappaB (NF-kappaB)-induced anti-apoptotic factors, thus enabling survival.
Positive_regulation (activate) of Positive_regulation (-induced) of nuclear factor-kappaB associated with apoptosis
4) Confidence 0.50 Published 2006 Journal Trends Mol Med Section Abstract Doc Link 16828345 Disease Relevance 0.67 Pain Relevance 0.19
The cytosolic level of the activated form of nuclear factor-kappa B (NF-kappaB), which is a major contributor to the induction of COX-2, on the ipsilateral side of the mouse spinal cord was also increased compared with that in the saline-treated mice.
Positive_regulation (increased) of Positive_regulation (activated) of NF-kappaB in spinal cord associated with spinal cord
5) Confidence 0.49 Published 2008 Journal Neuroscience Section Abstract Doc Link 18262365 Disease Relevance 0.92 Pain Relevance 0.74
S. pneumoniae infection resulted in a significant induction of NF-kappaB activity only in TLR9 stably transfected HEK 293 cells, but not in TLR2 and TLR4 transfected HEK 293 cells, and morphine treatment inhibited S. pneumoniae-induced NF-kappaB activity in these cells.
Positive_regulation (resulted) of Positive_regulation (induction) of NF-kappaB associated with infection and morphine
6) Confidence 0.49 Published 2008 Journal J. Immunol. Section Abstract Doc Link 18292587 Disease Relevance 0.79 Pain Relevance 0.58
Activation of NF-kappaB is required for PDGF-B chain to transform NIH3T3 cells.
Positive_regulation (required) of Positive_regulation (Activation) of NF-kappaB associated with aspirin
7) Confidence 0.46 Published 2002 Journal Exp. Cell Res. Section Title Doc Link 11855867 Disease Relevance 0.25 Pain Relevance 0.18
DHCD potently blocked nuclear factor-kappaB (NF-kappaB) activation, a process necessary for transcriptional activation of iNOS.
Positive_regulation (necessary) of Positive_regulation (activation) of NF-kappaB
8) Confidence 0.46 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14752064 Disease Relevance 0.08 Pain Relevance 0.16
While normal NF-kappaB activation is necessary for cell survival and immunity, deregulated NF-kappaB expression is a characteristic phenomenon in cancer development, as well as in several inflammatory diseases.
Positive_regulation (necessary) of Positive_regulation (activation) of NF-kappaB associated with inflammation, cancer and disease
9) Confidence 0.45 Published 2008 Journal Biochem. Pharmacol. Section Abstract Doc Link 17919455 Disease Relevance 0.38 Pain Relevance 0.10
Immunohistochemical or immunofluorescent examinations in the liver tissue generally support these findings, suggesting that PGE2 inhibited APAP-induced activation of nuclear factor kappa B (NF-kappaB).
Positive_regulation (induced) of Positive_regulation (activation) of nuclear factor kappa B in liver
10) Confidence 0.45 Published 2010 Journal Histol. Histopathol. Section Abstract Doc Link 20503171 Disease Relevance 0.27 Pain Relevance 0.19
Immunohistochemical or immunofluorescent examinations in the liver tissue generally support these findings, suggesting that PGE2 inhibited APAP-induced activation of nuclear factor kappa B (NF-kappaB).
Positive_regulation (induced) of Positive_regulation (activation) of NF-kappaB in liver
11) Confidence 0.45 Published 2010 Journal Histol. Histopathol. Section Abstract Doc Link 20503171 Disease Relevance 0.27 Pain Relevance 0.19
This revealed a progressive increase in NF-kappaB activation and IkBalpha depletion in lungs from mice in BL + CD groups from day 1 through day 21 compared with the corresponding SA + CD control groups.
Positive_regulation (increase) of Positive_regulation (activation) of NF-kappaB in lungs
12) Confidence 0.45 Published 2000 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10734156 Disease Relevance 0.15 Pain Relevance 0.17
To investigate the mechanism by which PEA attenuated hyperalgesia, we evaluated inhibitory kB-alpha (IkB-alpha) degradation and p65 nuclear factor kB (NF-kappaB) activation in DRG.
Positive_regulation (evaluated) of Positive_regulation (activation) of p65 nuclear factor kB in DRG associated with hyperalgesia
13) Confidence 0.45 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19386271 Disease Relevance 0.69 Pain Relevance 0.92
To investigate the mechanism by which PEA attenuated hyperalgesia, we evaluated inhibitory kB-alpha (IkB-alpha) degradation and p65 nuclear factor kB (NF-kappaB) activation in DRG.
Positive_regulation (evaluated) of Positive_regulation (activation) of NF-kappaB in DRG associated with hyperalgesia
14) Confidence 0.45 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19386271 Disease Relevance 0.69 Pain Relevance 0.92
These results also suggest that production of new proteins through NF-kappaB activation is required for the induction of allodynia.
Positive_regulation (required) of Positive_regulation (activation) of NF-kappaB associated with allodynia
15) Confidence 0.42 Published 2000 Journal Pain Section Abstract Doc Link 10666520 Disease Relevance 1.07 Pain Relevance 1.57
Furthermore, siegeskaurolic acid inhibited the nuclear factor-kappaB (NF-kappaB) activation induced by LPS, and this was associated with the prevention of inhibitor kappaB degradation (I kappaB), and subsequently with decreased nuclear p65 and p50 protein levels.
Positive_regulation (induced) of Positive_regulation (activation) of nuclear factor-kappaB
16) Confidence 0.40 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17207792 Disease Relevance 0.51 Pain Relevance 0.29
Taurine and niacin block lung injury and fibrosis by down-regulating bleomycin-induced activation of transcription nuclear factor-kappaB in mice.
Positive_regulation (induced) of Positive_regulation (activation) of nuclear factor-kappaB in lung associated with lung injury and fibrosis
17) Confidence 0.39 Published 2000 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 10734156 Disease Relevance 0.39 Pain Relevance 0.20
The increased potency may be related to an enhanced ability of NCX-1024 to prevent nuclear factor-kappaB activation.
Positive_regulation (enhanced) of Positive_regulation (activation) of nuclear factor-kappaB associated with potency
18) Confidence 0.38 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15128863 Disease Relevance 0.59 Pain Relevance 0.42
TLR signal either through the adaptor molecule MyD88 leading to activation of nuclear factor kappa B (NF?
Positive_regulation (leading) of Positive_regulation (activation) of nuclear factor kappa B
19) Confidence 0.37 Published 2010 Journal Heart Fail Rev Section Body Doc Link PMC3003782 Disease Relevance 0.11 Pain Relevance 0
Subsequent experiments revealed that acute ablation of GRP78 protein by AB5 subtilase cytotoxin caused reinforcement of MCP-1 induction and NF-kappaB activation by TNF-alpha and that transfection with GRP78 significantly suppressed the cytokine-induced activation of NF-kappaB.
Positive_regulation (induced) of Positive_regulation (activation) of NF-kappaB associated with cytokine
20) Confidence 0.34 Published 2008 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 18799549 Disease Relevance 0.31 Pain Relevance 0.18

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