INT69878

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Context Info
Confidence 0.29
First Reported 1997
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 48
Total Number 48
Disease Relevance 36.78
Pain Relevance 13.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

RNA binding (Gtf3a) nucleus (Gtf3a) intracellular (Gtf3a)
DNA binding (Gtf3a)
Anatomy Link Frequency
macrophage 7
fibroblast 6
skin 6
nerve 6
Schwann cell 4
Gtf3a (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 381 100.00 Very High Very High Very High
cytokine 344 100.00 Very High Very High Very High
Dopamine 83 100.00 Very High Very High Very High
metalloproteinase 57 100.00 Very High Very High Very High
Nerve growth factor 40 100.00 Very High Very High Very High
midbrain 20 100.00 Very High Very High Very High
withdrawal 9 100.00 Very High Very High Very High
Osteoarthritis 35 99.92 Very High Very High Very High
Demyelination 21 99.32 Very High Very High Very High
Hippocampus 2 98.86 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 460 100.00 Very High Very High Very High
INFLAMMATION 374 100.00 Very High Very High Very High
Apoptosis 169 100.00 Very High Very High Very High
Necrosis 49 100.00 Very High Very High Very High
Hyperglycemia 12 99.98 Very High Very High Very High
Osteoarthritis 35 99.92 Very High Very High Very High
Injury 149 99.90 Very High Very High Very High
Targeted Disruption 148 99.88 Very High Very High Very High
Hypoxia 18 99.76 Very High Very High Very High
Metastasis 91 99.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Transgenic mice overexpressing nerve growth factor (NGF) or glial cell line-derived neurotrophic factor (GDNF) in the skin possess a greatly increased number of nociceptors.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of factor in skin associated with targeted disruption, nerve growth factor and nociceptor
1) Confidence 0.29 Published 2005 Journal Pain Section Abstract Doc Link 15661434 Disease Relevance 1.03 Pain Relevance 0.51
Transgenic mice overexpressing nerve growth factor (NGF) or glial cell line-derived neurotrophic factor (GDNF) in the skin possess a greatly increased number of nociceptors.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of factor in skin associated with targeted disruption, nerve growth factor and nociceptor
2) Confidence 0.21 Published 2005 Journal Pain Section Abstract Doc Link 15661434 Disease Relevance 1.01 Pain Relevance 0.50
The splenocytes from protected mice and morphine low concentration-treated infected-PM, elaborated significantly (p < 0.05) enhanced levels of interleukin-12, interferon-gamma, tumor necrosis factor-alpha, granulocyte-macrophage colony-stimulating factor and nitrite in the culture medium; a high dose/concentration suppressed their elaboration.
Positive_regulation (enhanced) of Gene_expression (levels) of factor in macrophage associated with necrosis, cancer and morphine
3) Confidence 0.19 Published 2007 Journal J Neuroimmune Pharmacol Section Abstract Doc Link 18040852 Disease Relevance 0.62 Pain Relevance 0.76
A transgenic mouse has been developed which, during development, over-expresses nerve growth factor under the control of a myelin basic protein promoter.
Positive_regulation (over) of Gene_expression (over) of factor in nerve associated with targeted disruption and nerve growth factor
4) Confidence 0.15 Published 1999 Journal Neuroscience Section Abstract Doc Link 10199622 Disease Relevance 0.54 Pain Relevance 0.57
The splenocytes from protected mice and morphine low concentration-treated infected-PM, elaborated significantly (p < 0.05) enhanced levels of interleukin-12, interferon-gamma, tumor necrosis factor-alpha, granulocyte-macrophage colony-stimulating factor and nitrite in the culture medium; a high dose/concentration suppressed their elaboration.
Positive_regulation (enhanced) of Gene_expression (levels) of factor in macrophage associated with necrosis, cancer and morphine
5) Confidence 0.14 Published 2007 Journal J Neuroimmune Pharmacol Section Abstract Doc Link 18040852 Disease Relevance 0.62 Pain Relevance 0.78
A transgenic mouse has been developed which, during development, over-expresses nerve growth factor under the control of a myelin basic protein promoter.
Positive_regulation (over) of Gene_expression (expresses) of factor in nerve associated with targeted disruption and nerve growth factor
6) Confidence 0.10 Published 1999 Journal Neuroscience Section Abstract Doc Link 10199622 Disease Relevance 0.54 Pain Relevance 0.57
This work constitutes the first demonstration that lipoteichoic acid is sufficient to induce expression of a pro-angiogenic factor.
Positive_regulation (induce) of Gene_expression (expression) of factor
7) Confidence 0.09 Published 2003 Journal J. Dent. Res. Section Abstract Doc Link 12766200 Disease Relevance 0.20 Pain Relevance 0.14
Oral administration with a specific COX-2 or a nonspecific COX inhibitors lowered the expression of potent angiogenic factors; vascular endothelial growth factor and basic fibroblast growth factor, reduced angiogenesis and growth, induced apoptosis, and suppressed cell replication of the COX-2 overexpressing cancer xenografts in a dose-dependent manner.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of factor in fibroblast associated with cancer and apoptosis
8) Confidence 0.08 Published 1999 Journal Lab. Invest. Section Abstract Doc Link 10616198 Disease Relevance 0.83 Pain Relevance 0.10
Oral administration with a specific COX-2 or a nonspecific COX inhibitors lowered the expression of potent angiogenic factors; vascular endothelial growth factor and basic fibroblast growth factor, reduced angiogenesis and growth, induced apoptosis, and suppressed cell replication of the COX-2 overexpressing cancer xenografts in a dose-dependent manner.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of factor in fibroblast associated with cancer and apoptosis
9) Confidence 0.08 Published 1999 Journal Lab. Invest. Section Abstract Doc Link 10616198 Disease Relevance 0.84 Pain Relevance 0.10
Sympathetic axons surround nerve growth factor-immunoreactive trigeminal neurons: observations in mice overexpressing nerve growth factor.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of factor in nerve associated with nerve growth factor
10) Confidence 0.07 Published 1998 Journal J. Neurobiol. Section Title Doc Link 9514524 Disease Relevance 0.46 Pain Relevance 0.62
In separate experiments, Northern blot analysis showed that a 14-day treatment with imipramine (10 mg/kg b.i.d.) increased brain-derived neurotrophic factor (BDNF) mRNA expression in the cortex, whereas neramexane (5 mg/kg b.i.d.) decreased it.
Positive_regulation (increased) of Gene_expression (expression) of factor in cortex
11) Confidence 0.06 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16740621 Disease Relevance 0.06 Pain Relevance 0.67
Thyroid hormone and exercise stimulate expression of a nuclear respiratory factor (NRF) that induces the nuclear gene TFAM, which encodes the mitochondrial transcription factor A that controls mitochondrial replication and transcription.
Positive_regulation (stimulate) of Gene_expression (expression) of factor in respiratory
12) Confidence 0.05 Published 2003 Journal Ann. Clin. Lab. Sci. Section Abstract Doc Link 14584751 Disease Relevance 1.09 Pain Relevance 0.09
Contrary to accumulating evidence that portrays IL-1 as a maladaptive injury related cytokine IL-1 increases the expression of multiple growth and trophic factors, including fibroblast growth factor-2 [22], transforming growth factor ?
Positive_regulation (increases) of Gene_expression (expression) of factor in fibroblast associated with injury and cytokine
13) Confidence 0.03 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 1.38 Pain Relevance 0.50
This study characterized the production of tumor necrosis factor-alpha (TNF) induced by a skin irritant treatment, tributyltin (TBT), in mice through transcription factor activation and its pharmacologic modulation by anti-inflammatory agents.
Positive_regulation (induced) of Gene_expression (production) of factor in skin associated with necrosis, inflammation and cancer
14) Confidence 0.03 Published 1997 Journal J. Invest. Dermatol. Section Abstract Doc Link 9182817 Disease Relevance 0.52 Pain Relevance 0.17
mRNA and protein levels correlated with increased expression of the pro-lymphangiogenic factor VEGF-C and its cognate receptor, VEGFR-3.
Positive_regulation (increased) of Gene_expression (expression) of factor
15) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2791214 Disease Relevance 0.68 Pain Relevance 0.58
Hyperglycemia stimulates the transforming growth factor ?
Positive_regulation (stimulates) of Gene_expression (transforming) of factor associated with hyperglycemia
16) Confidence 0.03 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2674043 Disease Relevance 1.11 Pain Relevance 0.14
Hyperglycemia stimulates the transforming growth factor ?
Positive_regulation (transforming) of Gene_expression (transforming) of factor associated with hyperglycemia
17) Confidence 0.03 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2674043 Disease Relevance 1.06 Pain Relevance 0.14
To remove rheumatoid factor, the sera were treated with human IgG agarose (Sigma-Aldrich, St.
Positive_regulation (remove) of Gene_expression (remove) of rheumatoid factor
18) Confidence 0.03 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2760136 Disease Relevance 0.45 Pain Relevance 0.07
There is evidence that newly formed vasculature in genetically altered mice completely disappeared after a limited VEGF exposure, but that a longer duration of VEGF stimulation (10–14 days) resulted in the production of mature vessels even after withdrawal of the growth factor (14).
Positive_regulation (resulted) of Gene_expression (production) of factor in vessels associated with withdrawal
19) Confidence 0.02 Published 2009 Journal Pharm Res Section Body Doc Link PMC2812420 Disease Relevance 0.60 Pain Relevance 0.20
In OA studies it has been shown that diacerein exerts its protective action by down-regulating the production of cartilage degrading enzymes [8,32,33] through inhibiting the IL-1/IL-1 receptor system and increasing the production of tissue inhibitor of metalloprotease-1 [34], whereas it activates cartilage repair in OA by stimulating the production of transforming growth factor-?
Positive_regulation (stimulating) of Gene_expression (production) of factor in cartilage associated with osteoarthritis
20) Confidence 0.02 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400419 Disease Relevance 1.25 Pain Relevance 0.45

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