INT69882

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Context Info
Confidence 0.19
First Reported 1997
Last Reported 1997
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.60
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ptgs2) nuclear envelope (Ptgs2) oxidoreductase activity (Ptgs2)
endoplasmic reticulum (Ptgs2) nucleus (Ptgs2) plasma membrane (Ptger2)
Anatomy Link Frequency
PGE2 4
Ptger2 (Rattus norvegicus)
Ptgs2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 4 96.24 Very High Very High Very High
agonist 2 95.66 Very High Very High Very High
cINOD 4 92.48 High High
COX2 2 25.00 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 8 96.24 Very High Very High Very High
Drug Induced Neurotoxicity 2 58.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The observations that the lipopolysaccharide-induced prostanoid production was specifically increased by 11-deoxy-16,16-dm PGE2, a selective agonist at the PGE2 receptor EP2 coupled to the activation of adenylyl cyclase, and that the enhancing effect of PGE2 was partially prevented by specific inhibitors of adenylyl cyclase and protein kinase A, suggest that the up-regulation of cyclooxygenase-2 expression by PGE2 is mediated by cAMP, through a putative microglial EP2 receptor.
PGE2 Positive_regulation (up-regulation) of Gene_expression (expression) of cyclooxygenase-2 in PGE2 associated with agonist
1) Confidence 0.19 Published 1997 Journal Eur. J. Neurosci. Section Abstract Doc Link 9182946 Disease Relevance 0.34 Pain Relevance 0.27
In conclusion, while the strong up-regulation of cyclooxygenase-2 expression by exogenous PGE2 appears to be mediated by EP2 receptors and cAMP, the limited down-regulation caused by anti-inflammatory drug treatments may be either due to arachidonic acid metabolites other than PGE2, or to PGE2 itself, acting through a distinct cAMP-independent signalling pathway.
PGE2 Positive_regulation (up-regulation) of Gene_expression (expression) of cyclooxygenase-2 in PGE2 associated with inflammation
2) Confidence 0.19 Published 1997 Journal Eur. J. Neurosci. Section Abstract Doc Link 9182946 Disease Relevance 0.26 Pain Relevance 0.25

General Comments

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