INT69886

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Context Info
Confidence 0.76
First Reported 1997
Last Reported 2005
Negated 1
Speculated 0
Reported most in Abstract
Documents 8
Total Number 13
Disease Relevance 2.98
Pain Relevance 12.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ngf, Calca) aging (Ngf, Calca) extracellular region (Ngf, Calca)
signal transduction (Ngf) nucleus (Calca) intracellular (Calca)
Anatomy Link Frequency
nerve 4
neurons 2
sensory neurons 1
outflow 1
Ngf (Rattus norvegicus)
Calca (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 647 100.00 Very High Very High Very High
Calcitonin gene-related peptide 614 100.00 Very High Very High Very High
trigeminal ganglion 354 100.00 Very High Very High Very High
Neuropeptide 106 100.00 Very High Very High Very High
substance P 60 100.00 Very High Very High Very High
Inflammation 36 100.00 Very High Very High Very High
qutenza 312 99.20 Very High Very High Very High
c fibre 11 98.84 Very High Very High Very High
agonist 36 96.88 Very High Very High Very High
Cannabinoid 12 96.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 438 100.00 Very High Very High Very High
Nociception 53 100.00 Very High Very High Very High
INFLAMMATION 30 100.00 Very High Very High Very High
Hyperalgesia 42 92.80 High High
Injury 150 89.28 High High
Pain 20 68.60 Quite High
Hypersensitivity 12 7.04 Low Low
Headache 36 5.00 Very Low Very Low Very Low
Apoptosis 12 5.00 Very Low Very Low Very Low
Nervous System Injury 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the adult rat, nerve growth factor (NGF) upregulates the nociceptive peptide substance P (SP) and calcitonin gene-related peptide (CGRP) in neuronal cell bodies of C fibres but the effects of NGF on release of these neuropeptides from the central afferent terminals have not been reported.
NGF Positive_regulation (upregulates) of CGRP in nerve associated with nociception, c fibre, nerve growth factor, neuropeptide, calcitonin gene-related peptide and substance p
1) Confidence 0.76 Published 1997 Journal Eur. J. Neurosci. Section Abstract Doc Link 9182964 Disease Relevance 0.10 Pain Relevance 1.02
In the adult rat, nerve growth factor (NGF) upregulates the nociceptive peptide substance P (SP) and calcitonin gene-related peptide (CGRP) in neuronal cell bodies of C fibres but the effects of NGF on release of these neuropeptides from the central afferent terminals have not been reported.
nerve growth factor Positive_regulation (upregulates) of calcitonin gene-related peptide in nerve associated with nociception, c fibre, nerve growth factor, neuropeptide, calcitonin gene-related peptide and substance p
2) Confidence 0.76 Published 1997 Journal Eur. J. Neurosci. Section Abstract Doc Link 9182964 Disease Relevance 0.10 Pain Relevance 1.02
In the adult rat, nerve growth factor (NGF) upregulates the nociceptive peptide substance P (SP) and calcitonin gene-related peptide (CGRP) in neuronal cell bodies of C fibres but the effects of NGF on release of these neuropeptides from the central afferent terminals have not been reported.
NGF Positive_regulation (upregulates) of calcitonin gene-related peptide in nerve associated with nociception, c fibre, nerve growth factor, neuropeptide, calcitonin gene-related peptide and substance p
3) Confidence 0.76 Published 1997 Journal Eur. J. Neurosci. Section Abstract Doc Link 9182964 Disease Relevance 0.10 Pain Relevance 1.02
In the adult rat, nerve growth factor (NGF) upregulates the nociceptive peptide substance P (SP) and calcitonin gene-related peptide (CGRP) in neuronal cell bodies of C fibres but the effects of NGF on release of these neuropeptides from the central afferent terminals have not been reported.
nerve growth factor Positive_regulation (upregulates) of CGRP in nerve associated with nociception, c fibre, nerve growth factor, neuropeptide, calcitonin gene-related peptide and substance p
4) Confidence 0.76 Published 1997 Journal Eur. J. Neurosci. Section Abstract Doc Link 9182964 Disease Relevance 0.10 Pain Relevance 1.02
NGF (1.0 mg/kg s.c.) greatly increased basal and stimulus-evoked SP and CGRP release; at 0.1 mg/kg, NGF did not affect SP release but significantly increased CGRP basal outflow and evoked release.
NGF Neg (not) Positive_regulation (increased) of CGRP in outflow associated with nerve growth factor, calcitonin gene-related peptide and substance p
5) Confidence 0.66 Published 1997 Journal Eur. J. Neurosci. Section Abstract Doc Link 9182964 Disease Relevance 0.08 Pain Relevance 1.26
Much like K+-evoked CGRP release, total CGRP content was increased significantly by NGF and GDNF treatment, while BDNF had no effect (Fig. 6C).
NGF Positive_regulation (increased) of CGRP release associated with nerve growth factor and calcitonin gene-related peptide
6) Confidence 0.61 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0 Pain Relevance 0.84
Much like K+-evoked CGRP release, total CGRP content was increased significantly by NGF and GDNF treatment, while BDNF had no effect (Fig. 6C).
NGF Positive_regulation (increased) of CGRP associated with nerve growth factor and calcitonin gene-related peptide
7) Confidence 0.61 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0 Pain Relevance 0.83
Furthermore, NGF and GDNF increased the releasable pool and total content of CGRP while increasing TRPV1 protein, without increasing its mRNA.
NGF Positive_regulation (increased) of CGRP associated with nerve growth factor and calcitonin gene-related peptide
8) Confidence 0.44 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0.62 Pain Relevance 1.35
Both NGF and GDNF increased CGRP content concentration-dependently at every concentration (p < 0.001), with peaks at 10 ng/ml (3.2-fold increase) for NGF and 100 ng/ml (3.0-fold increase) for GDNF (Fig. 6C).
NGF Positive_regulation (increased) of CGRP associated with nerve growth factor and calcitonin gene-related peptide
9) Confidence 0.44 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0 Pain Relevance 0.80
As in the case with CAP, the effects of AEA and ACEA on evoked CGRP release were augmented by supplementation of TG cultures with NGF (Fig. 10A) or GDNF (Fig. 10B).
NGF Positive_regulation (augmented) of CGRP release associated with nerve growth factor, qutenza, trigeminal ganglion and calcitonin gene-related peptide
10) Confidence 0.41 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0.28 Pain Relevance 1.27
NGF increases the expression of the pro-inflammatory neuropeptide CGRP [13] and increases substance P (SP) and CGRP content in sensory neurons [14-17].
NGF Positive_regulation (increases) of CGRP in sensory neurons associated with inflammation, nerve growth factor, neuropeptide, substance p and calcitonin gene-related peptide
11) Confidence 0.41 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0.76 Pain Relevance 1.36
A second skin-derived factor nerve growth factor (NGF) also increased in wounded skin and increased CGRP in cultured adult dorsal root ganglia (DRG) neurons but with lower efficacy.
nerve growth factor Positive_regulation (increased) of CGRP in neurons associated with nerve growth factor and calcitonin gene-related peptide
12) Confidence 0.11 Published 2004 Journal Dev. Biol. Section Abstract Doc Link 15196945 Disease Relevance 0.42 Pain Relevance 0.49
A second skin-derived factor nerve growth factor (NGF) also increased in wounded skin and increased CGRP in cultured adult dorsal root ganglia (DRG) neurons but with lower efficacy.
NGF Positive_regulation (increased) of CGRP in neurons associated with nerve growth factor and calcitonin gene-related peptide
13) Confidence 0.11 Published 2004 Journal Dev. Biol. Section Abstract Doc Link 15196945 Disease Relevance 0.42 Pain Relevance 0.49

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