INT69888

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Context Info
Confidence 0.52
First Reported 1997
Last Reported 2006
Negated 1
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.51
Pain Relevance 4.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ngf, Calca) aging (Ngf, Calca) extracellular region (Ngf, Calca)
signal transduction (Ngf) nucleus (Calca) intracellular (Calca)
Anatomy Link Frequency
outflow 4
Nerve 1
dorsal horn 1
Ngf (Rattus norvegicus)
Calca (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 34 100.00 Very High Very High Very High
Calcitonin gene-related peptide 16 100.00 Very High Very High Very High
substance P 14 100.00 Very High Very High Very High
qutenza 11 100.00 Very High Very High Very High
Spinal cord 6 99.56 Very High Very High Very High
spinal dorsal horn 1 98.12 Very High Very High Very High
Neuropeptide 15 97.36 Very High Very High Very High
Dorsal horn 4 90.96 High High
c fibre 2 87.32 High High
Thermal hyperalgesia 1 79.84 Quite High
Disease Link Frequency Relevance Heat
Nociception 3 83.16 Quite High
Hyperalgesia 2 79.84 Quite High
Pain 1 66.40 Quite High
INFLAMMATION 3 66.04 Quite High
Wound Healing 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nerve growth factor treatment enhances release of immunoreactive calcitonin gene-related peptide but not substance P from spinal dorsal horn slices in rats.
Nerve growth factor Positive_regulation (enhances) of in Nerve Localization (release) of calcitonin in dorsal horn associated with nerve growth factor, spinal dorsal horn, substance p and calcitonin gene-related peptide
1) Confidence 0.52 Published 2004 Journal Neurosci. Lett. Section Title Doc Link 15182951 Disease Relevance 0 Pain Relevance 1.20
NGF (1.0 mg/kg s.c.) greatly increased basal and stimulus-evoked SP and CGRP release; at 0.1 mg/kg, NGF did not affect SP release but significantly increased CGRP basal outflow and evoked release.
NGF Positive_regulation (increased) of Localization (release) of CGRP in outflow associated with nerve growth factor, calcitonin gene-related peptide and substance p
2) Confidence 0.51 Published 1997 Journal Eur. J. Neurosci. Section Abstract Doc Link 9182964 Disease Relevance 0.08 Pain Relevance 1.28
NGF (1.0 mg/kg s.c.) greatly increased basal and stimulus-evoked SP and CGRP release; at 0.1 mg/kg, NGF did not affect SP release but significantly increased CGRP basal outflow and evoked release.
NGF Neg (not) Positive_regulation (increased) of Localization (release) of CGRP in outflow associated with nerve growth factor, calcitonin gene-related peptide and substance p
3) Confidence 0.44 Published 1997 Journal Eur. J. Neurosci. Section Abstract Doc Link 9182964 Disease Relevance 0.08 Pain Relevance 1.27
This NGF enhancement of capsaicin-evoked iCGRP release was not due solely to increases in peripheral iCGRP content since only the 1mg/kg dose of NGF elevated cutaneous pools of iCGRP, whereas both doses significantly increased capsaicin-evoked peptide release.
NGF Positive_regulation (enhancement) of Localization (release) of iCGRP associated with qutenza and nerve growth factor
4) Confidence 0.03 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16777323 Disease Relevance 0.35 Pain Relevance 1.21

General Comments

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