INT699
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Significant increases of serum alpha-2-macroglobulin (alpha-2-M) were detected in narcotic addicts presenting at a methadone treatment center. | |||||||||||||||
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Thus, the significantly increased serum trypsin-binding activity observed in the addicts is that which might be expected if normal alpha-2-M is being accumulated in large amounts as a result of increased macroglobulin synthesis. | |||||||||||||||
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Other studies have observed an increase of A2M in diabetic patients [41]. | |||||||||||||||
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The same associations were observed for proteins in univariate analysis with a decrease in ApoA1, haptoglobin and an increase of A2M in NASH. | |||||||||||||||
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Induction of labor at term pregnancy caused a significant rise of both PGE2-M and PGF2alpha-M. | |||||||||||||||
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Significant increases of serum alpha-2-macroglobulin (alpha-2-M) were detected in narcotic addicts presenting at a methadone treatment center. | |||||||||||||||
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Some studies have observed an increase of A2M in diabetic patients [48]. | |||||||||||||||
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The most notable elevation in alpha 2-macroglobulin occurred in Reiter's syndrome. | |||||||||||||||
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To measure the urine tubular enzymes N-acetyl-beta-glucosaminidase (NAG), alpha 1-microglobulin (alpha 1-M), and beta 2-microglobulin (beta 2-M) for renal tubular injury in both groups. | |||||||||||||||
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Estimation of antithrombin III, alpha 2 macroglobulin and alpha 1 antitrypsin in patients with stable and unstable angina and acute myocardial infarction (15 cases each) were carried out. | |||||||||||||||
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The patients showed evidence of defective fibrinolysis--namely, significant prolongation of the euglobulin clot-lysis time, reduction in fibrin-plate lysis-area and plasminogen levels, and increase in levels of the fibrinolytic inhibitors, alpha 2 antiplasmin and alpha 2 macroglobulin. | |||||||||||||||
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An increase of elastase 1, alpha 1-antitrypsin and alpha 2-macroglobulin was detected in pancreatic cancer, chronic pancreatitis and extra-pancreatic diseases; no changes were found for serum immunoreactive trypsin. | |||||||||||||||
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Furthermore, the latter group exhibited an elevation of F VIII activity, alpha 2-macroglobulin activity, and alpha 1-antitrypsin concentration and a significant reduction of antiplasmin activity despite a normal alpha 2-antiplasmin concentration. | |||||||||||||||
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Fecal excretion of another serum anti-proteinase, alpha2-macroglobulin, is also increased in IBD patients. | |||||||||||||||
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CONCLUSIONS: Urinary alpha1-M concentration is commonly increased in IBS, suggesting the presence of renal proximal tubular injury.
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Elevated levels of alpha-1-M and beta-NAG in chronic glomerulonephritis were interpreted as indicative for tubulointerstitial involvement in the chronic inflammatory process. | |||||||||||||||
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