INT699

Context Info Confidence 0.66 First Reported 1978 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 16 Total Number 16 Disease Relevance 10.49 Pain Relevance 2.50

cytosol (A2M) extracellular space (A2M) extracellular region (A2M) enzyme binding (A2M)

Anatomy Link Frequency proximal 1 Reiter 1 urine 1 A2M (Homo sapiens)

Pain Link Frequency Relevance Heat rheumatoid arthritis 5 99.24 anesthesia 5 99.08 epidural 3 98.64 Chronic pancreatitis 2 98.56 methadone 3 97.92 Angina 8 97.88 isoflurane 1 97.64 Inflammation 48 95.00 backache 2 90.92 Arthritis 1 89.56

Disease Link Frequency Relevance Heat Nash(non-alcoholic Steatohepatitis) 204 99.84 Inflammatory Bowel Disease 119 99.84 Diabetes Mellitus 14 99.84 Pancreatitis 7 99.80 Pancreatic Cancer 2 99.32 Rheumatoid Arthritis 6 99.24 Renal Disease 3 99.20 Syndrome 10 99.12 Insulin Resistance 11 98.48 Injury 19 98.44

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Significant increases of serum alpha-2-macroglobulin (alpha-2-M) were detected in narcotic addicts presenting at a methadone treatment center.

Positive_regulation (increases) of alpha-2-macroglobulin associated with methadone

1) Confidence 0.66 Published 1978 Journal Ann. Intern. Med. Section Abstract Doc Link 78676 Disease Relevance 0.15 Pain Relevance 0.10

Thus, the significantly increased serum trypsin-binding activity observed in the addicts is that which might be expected if normal alpha-2-M is being accumulated in large amounts as a result of increased macroglobulin synthesis.

Positive_regulation (accumulated) of alpha-2-M

2) Confidence 0.66 Published 1978 Journal Ann. Intern. Med. Section Abstract Doc Link 78676 Disease Relevance 0.23 Pain Relevance 0.06

Other studies have observed an increase of A2M in diabetic patients [41].

Positive_regulation (increase) of A2M associated with diabetes mellitus

3) Confidence 0.54 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1657015 Disease Relevance 1.31 Pain Relevance 0.04

The same associations were observed for proteins in univariate analysis with a decrease in ApoA1, haptoglobin and an increase of A2M in NASH.

Positive_regulation (increase) of A2M associated with nash(non-alcoholic steatohepatitis)

4) Confidence 0.47 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1657015 Disease Relevance 1.92 Pain Relevance 0.03

Induction of labor at term pregnancy caused a significant rise of both PGE2-M and PGF2alpha-M.

Positive_regulation (rise) of PGE2-M

5) Confidence 0.46 Published 1978 Journal Am. J. Obstet. Gynecol. Section Abstract Doc Link 677189 Disease Relevance 0.25 Pain Relevance 0.17

Significant increases of serum alpha-2-macroglobulin (alpha-2-M) were detected in narcotic addicts presenting at a methadone treatment center.

Positive_regulation (increases) of alpha-2-M associated with methadone

6) Confidence 0.44 Published 1978 Journal Ann. Intern. Med. Section Abstract Doc Link 78676 Disease Relevance 0.15 Pain Relevance 0.10

Some studies have observed an increase of A2M in diabetic patients [48].

Positive_regulation (increase) of A2M associated with diabetes mellitus

7) Confidence 0.27 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1386692 Disease Relevance 1.27 Pain Relevance 0.10

The most notable elevation in alpha 2-macroglobulin occurred in Reiter's syndrome.

Positive_regulation (elevation) of alpha 2-macroglobulin in Reiter associated with syndrome

8) Confidence 0.13 Published 1987 Journal Clin. Rheumatol. Section Abstract Doc Link 2438080 Disease Relevance 1.35 Pain Relevance 0.27

To measure the urine tubular enzymes N-acetyl-beta-glucosaminidase (NAG), alpha 1-microglobulin (alpha 1-M), and beta 2-microglobulin (beta 2-M) for renal tubular injury in both groups.

Positive_regulation (measure) of alpha 1-M in urine associated with injury

9) Confidence 0.06 Published 1994 Journal J Clin Anesth Section Abstract Doc Link 7527229 Disease Relevance 0.10 Pain Relevance 0.65

Estimation of antithrombin III, alpha 2 macroglobulin and alpha 1 antitrypsin in patients with stable and unstable angina and acute myocardial infarction (15 cases each) were carried out.

Positive_regulation (Estimation) of alpha 2 macroglobulin associated with angina and myocardial infarction

10) Confidence 0.05 Published 1990 Journal Indian Heart J Section Abstract Doc Link 1711506 Disease Relevance 0.67 Pain Relevance 0.22

The patients showed evidence of defective fibrinolysis--namely, significant prolongation of the euglobulin clot-lysis time, reduction in fibrin-plate lysis-area and plasminogen levels, and increase in levels of the fibrinolytic inhibitors, alpha 2 antiplasmin and alpha 2 macroglobulin.

Positive_regulation (increase) of alpha 2 macroglobulin

11) Confidence 0.04 Published 1984 Journal Lancet Section Abstract Doc Link 6150238 Disease Relevance 0.51 Pain Relevance 0.21

An increase of elastase 1, alpha 1-antitrypsin and alpha 2-macroglobulin was detected in pancreatic cancer, chronic pancreatitis and extra-pancreatic diseases; no changes were found for serum immunoreactive trypsin.

Positive_regulation (increase) of alpha 2-macroglobulin associated with pancreatitis, pancreatic cancer and chronic pancreatitis

12) Confidence 0.03 Published 1986 Journal Enzyme Section Abstract Doc Link 2427333 Disease Relevance 0.76 Pain Relevance 0.20

Furthermore, the latter group exhibited an elevation of F VIII activity, alpha 2-macroglobulin activity, and alpha 1-antitrypsin concentration and a significant reduction of antiplasmin activity despite a normal alpha 2-antiplasmin concentration.

Positive_regulation (elevation) of 2-macroglobulin

13) Confidence 0.01 Published 1992 Journal Am. J. Med. Section Body Doc Link 1466361 Disease Relevance 0 Pain Relevance 0

Fecal excretion of another serum anti-proteinase, alpha2-macroglobulin, is also increased in IBD patients.

Positive_regulation (increased) of alpha2-macroglobulin associated with inflammatory bowel disease

14) Confidence 0.01 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2827710 Disease Relevance 1.04 Pain Relevance 0.16

CONCLUSIONS: Urinary alpha1-M concentration is commonly increased in IBS, suggesting the presence of renal proximal tubular injury.

Positive_regulation (increased) of alpha1-M in proximal

15) Confidence 0.01 Published 2005 Journal Eur J Gastroenterol Hepatol Section Body Doc Link 15647644 Disease Relevance 0 Pain Relevance 0

Elevated levels of alpha-1-M and beta-NAG in chronic glomerulonephritis were interpreted as indicative for tubulointerstitial involvement in the chronic inflammatory process.

Positive_regulation (levels) of alpha-1-M associated with inflammation and renal disease

16) Confidence 0.01 Published 1989 Journal Klin. Wochenschr. Section Abstract Doc Link 2472510 Disease Relevance 0.71 Pain Relevance 0.21

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