INT69913

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Context Info
Confidence 0.13
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 0.83
Pain Relevance 0.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (ATF2) nucleolus (ATF2) nucleus (ATF2)
intracellular (ATF2) DNA binding (ATF2)
Anatomy Link Frequency
brain 2
ATF2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 8 99.42 Very High Very High Very High
bDMF 16 93.24 High High
cytokine 34 91.60 High High
nMDA receptor 1 71.16 Quite High
addiction 4 68.64 Quite High
tolerance 4 67.44 Quite High
Inflammatory response 2 53.16 Quite High
Central nervous system 26 50.00 Quite Low
Serotonin 3 20.44 Low Low
Neurotransmitter 2 17.52 Low Low
Disease Link Frequency Relevance Heat
Manic Depressive Disorder 125 97.20 Very High Very High Very High
Targeted Disruption 2 60.40 Quite High
Post-traumatic Stress Disorder 1 56.48 Quite High
INFLAMMATION 10 52.76 Quite High
Stress 5 41.76 Quite Low
Death 2 12.64 Low Low
Necrosis 2 8.68 Low Low
Cancer 3 8.32 Low Low
Injury 2 5.48 Low Low
Disease 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MAPK can phosphorylate a variety of transcription factors, for example, ATF2, ELK1, CREB, MEF2C, CHOP/GADD153, and C/EBP?
ATF2 Binding (example) of
1) Confidence 0.13 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604896 Disease Relevance 0.11 Pain Relevance 0.22
We have previously demonstrated that chronic morphine treatment decreases the DNA binding activity of ssCRE-BP (single-stranded cyclic AMP response element-binding protein), which has been shown to be identical to pur alpha by cDNA cloning, and is abundant in the brain.
ssCRE-BP Binding (binding) of in brain associated with morphine
2) Confidence 0.05 Published 1997 Journal Neurochem. Int. Section Abstract Doc Link 9185164 Disease Relevance 0 Pain Relevance 0.10
Another interesting finding was reported in the paper by Mamdani and coworkers, in which the authors investigated the association between CREB1, CREB2 and CREB3 genes and response to lithium in a sample comprised of 180 BD lithium responders, 69 non responders and 127 controls [189].
CREB2 Binding (association) of associated with manic depressive disorder
3) Confidence 0.04 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958627 Disease Relevance 0.72 Pain Relevance 0.12
Casein could substitute for the activator and increased the DNA binding activity of ssCRE-BP/pur alpha by one order.
ssCRE-BP Binding (activity) of
4) Confidence 0.04 Published 1997 Journal Neurochem. Int. Section Abstract Doc Link 9185164 Disease Relevance 0 Pain Relevance 0.21
We have previously demonstrated that chronic morphine treatment decreases the DNA binding activity of ssCRE-BP (single-stranded cyclic AMP response element-binding protein), which has been shown to be identical to pur alpha by cDNA cloning, and is abundant in the brain.
ssCRE-BP Binding (activity) of in brain associated with morphine
5) Confidence 0.04 Published 1997 Journal Neurochem. Int. Section Abstract Doc Link 9185164 Disease Relevance 0 Pain Relevance 0.10
Characterization of a nuclear factor that enhances DNA binding activity of SSCRE-BP/PUR alpha, a single-stranded DNA binding protein.
SSCRE-BP Binding (binding) of
6) Confidence 0.04 Published 1997 Journal Neurochem. Int. Section Title Doc Link 9185164 Disease Relevance 0 Pain Relevance 0.09

General Comments

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