INT69917

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Context Info
Confidence 0.58
First Reported 1997
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 2.28
Pain Relevance 1.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (CREB1) signal transduction (CREB1) mitochondrion (CREB1)
nucleolus (CREB1) nucleus (CREB1) transcription factor binding (CREB1)
Anatomy Link Frequency
dorsal horn 2
brain 1
A549 1
body 1
T cells 1
CREB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 35 99.84 Very High Very High Very High
Morphine 2 99.78 Very High Very High Very High
spinal dorsal horn 6 99.68 Very High Very High Very High
allodynia 4 92.16 High High
intrathecal 2 79.72 Quite High
Neuropathic pain 8 75.00 Quite High
antiallodynic 2 75.00 Quite High
alcohol 100 62.96 Quite High
Pain 2 52.32 Quite High
Inflammation 34 52.12 Quite High
Disease Link Frequency Relevance Heat
Bordatella Infection 7 98.96 Very High Very High Very High
Body Weight 2 98.24 Very High Very High Very High
Neuropathic Pain 12 92.16 High High
Cv Unclassified Under Development 15 84.52 Quite High
Death 3 82.76 Quite High
Keloid Scars 3 81.40 Quite High
Hypertrophy 1 80.88 Quite High
Nervous System Injury 10 78.56 Quite High
Hypersensitivity 9 75.68 Quite High
Apoptosis 1 64.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Western blot results showed that the alleviation in intensity of behavioral performance was accompanied by a significant reduction of total cyclic AMP response element-binding protein and phosphorylated cyclic AMP response element-binding protein in the spinal dorsal horn.
Negative_regulation (reduction) of cyclic AMP response element-binding protein in dorsal horn associated with spinal dorsal horn
1) Confidence 0.58 Published 2006 Journal Neuroscience Section Abstract Doc Link 16515839 Disease Relevance 0.81 Pain Relevance 0.70
Western blot results showed that the alleviation in intensity of behavioral performance was accompanied by a significant reduction of total cyclic AMP response element-binding protein and phosphorylated cyclic AMP response element-binding protein in the spinal dorsal horn.
Negative_regulation (reduction) of cyclic AMP response element-binding protein in dorsal horn associated with spinal dorsal horn
2) Confidence 0.50 Published 2006 Journal Neuroscience Section Abstract Doc Link 16515839 Disease Relevance 0.81 Pain Relevance 0.64
We have previously demonstrated that chronic morphine treatment decreases the DNA binding activity of ssCRE-BP (single-stranded cyclic AMP response element-binding protein), which has been shown to be identical to pur alpha by cDNA cloning, and is abundant in the brain.
Negative_regulation (decreases) of single-stranded cyclic AMP response element-binding protein in brain associated with morphine
3) Confidence 0.48 Published 1997 Journal Neurochem. Int. Section Abstract Doc Link 9185164 Disease Relevance 0 Pain Relevance 0.10
The representative blot in Figure 4a indicates that pCREB levels were dramatically reduced in Ethanol treated animals but similar to control levels in Ethanol+Vinpocetine ones.
Negative_regulation (cally r) of pCREB
4) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2721629 Disease Relevance 0 Pain Relevance 0.08
Blots were incubated in blocking buffer (LI-COR, Lincoln, NE) for 1 hour, then incubated in Phospho-CREB (Ser133) (87G3) rabbit mAb (1?
Negative_regulation (blocking) of CREB
5) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2721629 Disease Relevance 0 Pain Relevance 0
S binding and CREB activity inhibition were highly sensitive to pertussis toxin.
Negative_regulation (inhibition) of CREB associated with bordatella infection
6) Confidence 0.15 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2839267 Disease Relevance 0.10 Pain Relevance 0
Studies of the role of CREB in T cells have provided conflicting results with regard to whether CREB is a positive or negative regulator of cytokine transcription.
Spec (whether) Negative_regulation (regulator) of CREB in T cells associated with cytokine
7) Confidence 0.14 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0.06 Pain Relevance 0.08
CREB-phosphorylation was also markedly reduced after p38 inhibition, as shown by confocal microscopy (>99% in A498 cells, >50% in A549 cells, Figure 4H) and Western blots (Figure S7).
Negative_regulation (reduced) of CREB in A549
8) Confidence 0.10 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2944801 Disease Relevance 0 Pain Relevance 0
After 7 days of removal of doxycycline followed by restoration of inhibition of the tet-transactivator protein for 7, 14 and 21 days, the heart weight to body weight ratio decreased gradually (7 day 0.0070±0.0016; 14 day 0.0052±0.0008 and 21 day 0.0055±0.0013) towards the ratio seen in the on-doxycycline control (0.0047±0.0002).
Negative_regulation (inhibition) of tet-transactivator protein in body associated with body weight
9) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908132 Disease Relevance 0.50 Pain Relevance 0

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