INT69922

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Context Info
Confidence 0.05
First Reported 1997
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.28
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (ATF2) nucleolus (ATF2) nucleus (ATF2)
intracellular (ATF2) DNA binding (ATF2)
Anatomy Link Frequency
brain 1
T cells 1
ATF2 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 77 96.88 Very High Very High Very High
Morphine 4 96.60 Very High Very High Very High
addiction 2 96.24 Very High Very High Very High
tolerance 3 95.64 Very High Very High Very High
Osteoarthritis 32 82.24 Quite High
Arthritis 2 50.00 Quite Low
Leflunomide 15 5.00 Very Low Very Low Very Low
methotrexate 14 5.00 Very Low Very Low Very Low
Inflammation 13 5.00 Very Low Very Low Very Low
cytokine 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Frailty 34 98.20 Very High Very High Very High
Rheumatoid Arthritis 122 96.88 Very High Very High Very High
Morphine Dependence 2 96.60 Very High Very High Very High
Disease 29 77.96 Quite High
Leukemia 1 45.04 Quite Low
Disease Progression 6 8.44 Low Low
INFLAMMATION 12 5.00 Very Low Very Low Very Low
Autoimmune Disease 7 5.00 Very Low Very Low Very Low
Arthritis 3 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest that the DNA binding activity of ssCRE-BP/pur alpha is augmented by a nuclear protein, which may modulate the ssCRE-BP/pur alpha activity to develop morphine dependence and tolerance.
Positive_regulation (augmented) of ssCRE-BP associated with addiction, tolerance and morphine
1) Confidence 0.05 Published 1997 Journal Neurochem. Int. Section Abstract Doc Link 9185164 Disease Relevance 0.10 Pain Relevance 0.25
In this report we identified an activator of ssCRE-BP/pur alpha in the brain and characterized it.
Positive_regulation (activator) of ssCRE-BP in brain
2) Confidence 0.05 Published 1997 Journal Neurochem. Int. Section Abstract Doc Link 9185164 Disease Relevance 0 Pain Relevance 0.09
We identified elevated levels of phosphorylated (p)-AKT, p-p38, p-JNK, p-STAT1, p-STAT3, p-STAT5, p-ATF2, p-cdc2, p-p120, p-PKARIIb and p-src in joint infiltrating CD3+ T cells (Figure 1).
Positive_regulation (elevated) of p-ATF2 in T cells
3) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2724743 Disease Relevance 1.18 Pain Relevance 0.40

General Comments

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