INT6993

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Context Info
Confidence 0.59
First Reported 1992
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 72
Total Number 75
Disease Relevance 61.83
Pain Relevance 19.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mpo) extracellular space (Mpo) oxidoreductase activity (Mpo)
lysosome (Mpo)
Anatomy Link Frequency
neutrophil 7
lung 6
paw 5
ear 5
colon 3
Mpo (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 197 100.00 Very High Very High Very High
electroacupuncture 26 99.70 Very High Very High Very High
Spinal cord 167 99.68 Very High Very High Very High
Inflammation 1061 99.66 Very High Very High Very High
Opioid 86 99.64 Very High Very High Very High
Calcitonin gene-related peptide 12 99.04 Very High Very High Very High
COX-2 inhibitor 4 99.02 Very High Very High Very High
cytokine 652 98.96 Very High Very High Very High
Paracetamol 14 98.32 Very High Very High Very High
Thermal hyperalgesia 1 98.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Injury 740 100.00 Very High Very High Very High
Urological Neuroanatomy 477 100.00 Very High Very High Very High
Pressure And Volume Under Development 214 100.00 Very High Very High Very High
Pleurisy 23 100.00 Very High Very High Very High
Diarrhoea 11 100.00 Very High Very High Very High
Myocardial Infarction 91 99.96 Very High Very High Very High
Melioidosis 114 99.70 Very High Very High Very High
INFLAMMATION 1129 99.66 Very High Very High Very High
Colitis 229 99.62 Very High Very High Very High
Targeted Disruption 101 99.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our work has shown that orally administered 5-lipoxygenase inhibitors, dual inhibitors (CO/LO), and steroids dose-dependently inhibit both edema formation and MPO activity, whereas oral activity is not seen with NSAID's.
Negative_regulation (inhibit) of MPO associated with pressure and volume under development, cinod and urological neuroanatomy
1) Confidence 0.59 Published 1993 Journal Agents Actions Section Abstract Doc Link 8273582 Disease Relevance 0.88 Pain Relevance 0.26
Cannabidiol suppressed the decrease in cerebral blood flow by the failure of cerebral microcirculation after reperfusion and inhibited MPO activity in neutrophils.
Negative_regulation (inhibited) of MPO in blood associated with urological neuroanatomy
2) Confidence 0.59 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17437545 Disease Relevance 0.58 Pain Relevance 0.27
It is also noteworthy that while head protection did not prevent inflammation in the brain, it did reduce MPO activity in the gastrointestinal tract.
Negative_regulation (reduce) of MPO in head associated with inflammation and urological neuroanatomy
3) Confidence 0.58 Published 2010 Journal Frontiers in Neurology Section Body Doc Link PMC3009449 Disease Relevance 1.13 Pain Relevance 0.26
In the PMA model, M. indica extract also reduced myeloperoxidase (MPO) activity.
Negative_regulation (reduced) of MPO associated with urological neuroanatomy
4) Confidence 0.57 Published 2006 Journal Phytomedicine Section Abstract Doc Link 16716910 Disease Relevance 0.38 Pain Relevance 0.09
In the PMA model, M. indica extract also reduced myeloperoxidase (MPO) activity.
Negative_regulation (reduced) of myeloperoxidase associated with urological neuroanatomy
5) Confidence 0.57 Published 2006 Journal Phytomedicine Section Abstract Doc Link 16716910 Disease Relevance 0.38 Pain Relevance 0.09
Biochemical assays well indicated that administration of Z. multiflora reduces MPO activity and TBARS concentrations, both of which are established indicators of oxidative stress and markers of colitis (8,11,19).
Negative_regulation (reduces) of MPO associated with colitis, stress and urological neuroanatomy
6) Confidence 0.57 Published 2007 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1810372 Disease Relevance 1.07 Pain Relevance 0.03
In Figure 3 data are displayed demonstrating that even at 30 minutes after incision, MPO activity was measurably increased from baseline, and that 10 mg/kg but not 0.1 mg/kg morphine injection prior to incision strongly reduced the MPO activity at both time points.


Negative_regulation (reduced) of MPO associated with urological neuroanatomy and morphine
7) Confidence 0.56 Published 2007 Journal Mol Pain Section Body Doc Link PMC2096620 Disease Relevance 0.75 Pain Relevance 0.85
Fecho et al. reported recently that the hind paw swelling induced by carrageenan injection could be reduced by morphine, and that MPO levels could be lowered by this opioid as well [15].
Negative_regulation (lowered) of MPO in paw associated with pressure and volume under development, urological neuroanatomy, opioid and morphine
8) Confidence 0.56 Published 2007 Journal Mol Pain Section Body Doc Link PMC2096620 Disease Relevance 0.77 Pain Relevance 1.13
However, both hydrocortisone and MPM seem to inhibit neutrophil extravasation and accumulation in inflamed tissues as shown with a higher polymorphonuclear cells (PMN) in circulation as well as a reduced MPO content in ear (Figures 4 and 5).
Negative_regulation (reduced) of MPO in ear associated with urological neuroanatomy
9) Confidence 0.55 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1845142 Disease Relevance 0.75 Pain Relevance 0.13
Significant reduction in plasma tumor necrosis factor-alpha and keratinocyte-derived chemokine, as well as reductions in myeloperoxidase activity, intracellular adhesion molecule-1 protein expression, mRNA concentrations of proinflammatory markers, and apoptosis were observed in renal cortices from both local anesthetic groups.
Negative_regulation (reductions) of myeloperoxidase in keratinocyte
10) Confidence 0.54 Published 2004 Journal Anesthesiology Section Body Doc Link 15448523 Disease Relevance 0.13 Pain Relevance 0
Administration of CORM-2 significantly decreased MPO activity (21.6±5.4 vs 32.8 ±3.3 unit/g tissue, P <0.05) compared with burn group.
Negative_regulation (decreased) of MPO associated with burns and urological neuroanatomy
11) Confidence 0.53 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2430988 Disease Relevance 1.70 Pain Relevance 0
MPO activity was markedly reduced in the lungs (Figure 10A) and gut (Figure 10B) of zymosan-challenged mice treated with GW0742.


Negative_regulation (reduced) of MPO in lungs associated with urological neuroanatomy
12) Confidence 0.52 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2844385 Disease Relevance 0.52 Pain Relevance 0.08
Biochemical analysis showed a significant increase in lipid peroxidation, nitrite and myeloperoxidase levels and a decrease in the reduced glutathione (GSH) levels in brain homogenates.
Negative_regulation (decrease) of myeloperoxidase in brain
13) Confidence 0.43 Published 2008 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 18336891 Disease Relevance 0.49 Pain Relevance 0.33
Enhancement of both cell migration and myeloperoxidase levels, 4 h after pleurisy induction, was effectively inhibited by all studied drugs.
Negative_regulation (inhibited) of myeloperoxidase associated with pleurisy
14) Confidence 0.43 Published 1999 Journal Peptides Section Abstract Doc Link 10503773 Disease Relevance 0.33 Pain Relevance 0.28
A glucocorticoid (dexamethasone), two cyclooxygenase inhibitors (indomethacin, piroxicam) and an interleukin-1 (IL-1) release inhibitor (IX 207-887, Sandoz) all reduced edema and MPO activity as well.
Negative_regulation (reduced) of MPO associated with pressure and volume under development, urological neuroanatomy and dexamethasone
15) Confidence 0.43 Published 1993 Journal Agents Actions Section Abstract Doc Link 8304241 Disease Relevance 0.96 Pain Relevance 0.47
There is a good correlation between the inhibition of edema formation and of MPO activity by these compounds.
Negative_regulation (inhibition) of MPO associated with pressure and volume under development and urological neuroanatomy
16) Confidence 0.43 Published 1993 Journal Agents Actions Section Abstract Doc Link 8273582 Disease Relevance 0.87 Pain Relevance 0.26
Previous studies have indicated increased MPO activity following NEP inhibition (Umeno et al. 1989; Barbara et al. 2003).
Negative_regulation (inhibition) of MPO associated with urological neuroanatomy
17) Confidence 0.43 Published 2009 Journal Toxicology Mechanisms and Methods Section Body Doc Link PMC2736052 Disease Relevance 1.74 Pain Relevance 0.24
Furthermore, mouse ear myeloperoxidase (MPO) activity, an indicator of polymorphonuclear leukocyte infiltration, was assessed and found to be significantly (P < 0.05) reduced after topical application of indomethacin and all blackberry preparations.
Negative_regulation (reduced) of myeloperoxidase in polymorphonuclear leukocyte associated with urological neuroanatomy
18) Confidence 0.43 Published 2010 Journal J. Agric. Food Chem. Section Abstract Doc Link 20415425 Disease Relevance 0.68 Pain Relevance 0.25
Furthermore, mouse ear myeloperoxidase (MPO) activity, an indicator of polymorphonuclear leukocyte infiltration, was assessed and found to be significantly (P < 0.05) reduced after topical application of indomethacin and all blackberry preparations.
Negative_regulation (reduced) of MPO in polymorphonuclear leukocyte associated with urological neuroanatomy
19) Confidence 0.43 Published 2010 Journal J. Agric. Food Chem. Section Abstract Doc Link 20415425 Disease Relevance 0.68 Pain Relevance 0.25
In mice, mS100A9p inhibited thermal and mechanical hyperalgesia and allodynia induced by either carrageenan or formalin, without interfering with paw edema. mS100A9p also inhibited myeloperoxidase activity (MPO), a marker of granulocyte infiltration, induced by carrageenan, but increased MPO after formalin intraplantar injection.
Negative_regulation (inhibited) of myeloperoxidase in granulocyte associated with pressure and volume under development, hyperalgesia, allodynia and urological neuroanatomy
20) Confidence 0.43 Published 2009 Journal Fundam Clin Pharmacol Section Abstract Doc Link 19515068 Disease Relevance 0.67 Pain Relevance 0.61

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