INT69938

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Context Info
Confidence 0.29
First Reported 1997
Last Reported 2000
Negated 0
Speculated 0
Reported most in Title
Documents 2
Total Number 4
Disease Relevance 0
Pain Relevance 3.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Abat) extracellular space (Cck) extracellular region (Cck)
Anatomy Link Frequency
anterior 4
interneurons 2
Cck (Rattus norvegicus)
Abat (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cholecystokinin 54 100.00 Very High Very High Very High
gABA 30 100.00 Very High Very High Very High
Nucleus accumbens 6 99.16 Very High Very High Very High
Neurotransmitter 1 94.68 High High
Hippocampus 1 92.88 High High
interneuron 1 88.48 High High
antagonist 16 79.68 Quite High
Pyramidal cell 3 78.68 Quite High
Action potential 3 76.24 Quite High
tetrodotoxin 7 70.68 Quite High
Disease Link Frequency Relevance Heat
Convulsion 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cholecystokinin (CCK) increases GABA release in the rat anterior nucleus accumbens via CCK(B) receptors located on glutamatergic interneurons.
Cholecystokinin Positive_regulation (increases) of Localization (release) of GABA in anterior associated with nucleus accumbens, gaba and cholecystokinin
1) Confidence 0.29 Published 2000 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Title Doc Link 10651144 Disease Relevance 0 Pain Relevance 1.03
Cholecystokinin (CCK) increases GABA release in the rat anterior nucleus accumbens via CCK(B) receptors located on glutamatergic interneurons.
CCK Positive_regulation (increases) of Localization (release) of GABA in anterior associated with nucleus accumbens, gaba and cholecystokinin
2) Confidence 0.28 Published 2000 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Title Doc Link 10651144 Disease Relevance 0 Pain Relevance 1.03
CCK-8S in a concentration dependent manner (10-3000 nM) increased K+-evoked [3H]GABA release (EC50=192 nM).
CCK-8S Positive_regulation (increased) of Localization (release) of GABA associated with gaba and cholecystokinin
3) Confidence 0.25 Published 2000 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 10651144 Disease Relevance 0 Pain Relevance 0.84
Cholecystokinin increases GABA release by inhibiting a resting K+ conductance in hippocampal interneurons.
Cholecystokinin Positive_regulation (increases) of Localization (release) of GABA in interneurons associated with gaba and cholecystokinin
4) Confidence 0.15 Published 1997 Journal J. Neurosci. Section Title Doc Link 9185537 Disease Relevance 0 Pain Relevance 0.89

General Comments

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