INT69941

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Context Info
Confidence 0.67
First Reported 1997
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 10
Disease Relevance 1.53
Pain Relevance 5.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Pnoc)
Anatomy Link Frequency
NS20Y 8
spinal trigeminal nucleus 3
medial preoptic nucleus 2
lateral lemniscus nucleus 2
spinal 1
Pnoc (Mus musculus)
Pnoc - N23K (2) Pnoc - N27K (1)
Pain Link Frequency Relevance Heat
orphanin 40 100.00 Very High Very High Very High
Neuropeptide 14 100.00 Very High Very High Very High
Substantia nigra 16 98.32 Very High Very High Very High
Glutamate 4 97.60 Very High Very High Very High
medulla 8 96.88 Very High Very High Very High
antagonist 4 95.88 Very High Very High Very High
Antinociceptive 2 95.04 Very High Very High Very High
spinal dorsal horn 2 94.08 High High
depression 2 93.60 High High
Raphe magnus 2 92.60 High High
Disease Link Frequency Relevance Heat
Parkinson's Disease 4 96.36 Very High Very High Very High
Depression 2 93.60 High High
Urological Neuroanatomy 4 91.92 High High
Hypokinesia 2 86.36 High High
Disease 8 81.88 Quite High
Pain 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In 6-hydroxydopamine hemilesioned rats, enhancement of N/OFQ expression and release was detected in the lesioned compared with the unlesioned SN, indicating that parkinsonism may be associated with overactivation of the N/OFQ-NOP receptor system in the SN.
Positive_regulation (enhancement) of Gene_expression (expression) of N/OFQ associated with parkinson's disease and substantia nigra
1) Confidence 0.67 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16237164 Disease Relevance 0.59 Pain Relevance 0.86
High to moderate levels of prepronociceptin messenger RNA expression were detected in the lateral, ventral and medial septum, and were evident in brainstem structures implicated in descending antinociceptive pathways (e.g., the gigantocellular nucleus, raphe magnus nucleus, periaqueductal gray matter), and also observed in association with auditory relay nuclei such as the inferior colliculi, lateral lemniscus nucleus, medioventral preolivary nucleus and lateral superior nucleus.
Positive_regulation (levels) of Gene_expression (expression) of prepronociceptin in lateral lemniscus nucleus associated with raphe magnus, medulla, central grey and antinociceptive
2) Confidence 0.61 Published 1999 Journal Neuroscience Section Abstract Doc Link 10391477 Disease Relevance 0.09 Pain Relevance 0.37
We recently discovered N23K and its splicing variant N27K as transcripts upregulated in mouse NS20Y cells after differentiation induced by dibutylyl cyclic AMP (dbcAMP) treatment.
Positive_regulation (discovered) of Gene_expression (discovered) of N23K (N23K) in NS20Y
3) Confidence 0.50 Published 1997 Journal J. Neurosci. Res. Section Abstract Doc Link 9185664 Disease Relevance 0 Pain Relevance 0.32
Overexpression of a neuropeptide nociceptin/orphanin FQ precursor gene, N23K/N27K, induces neurite outgrowth in mouse NS20Y cells.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of N23K (N23K) in NS20Y associated with orphanin and neuropeptide
4) Confidence 0.50 Published 1997 Journal J. Neurosci. Res. Section Title Doc Link 9185664 Disease Relevance 0 Pain Relevance 0.42
A moderate level of prepronociceptin messenger RNA expression was observed in the medial preoptic nucleus, ventromedial preoptic nucleus, periventricular nucleus, pedonculopontine tegmental nucleus, solitary tract nucleus and spinal trigeminal nucleus.
Positive_regulation (level) of Gene_expression (expression) of prepronociceptin in medial preoptic nucleus
5) Confidence 0.50 Published 1999 Journal Neuroscience Section Abstract Doc Link 10391477 Disease Relevance 0.09 Pain Relevance 0.46
PreproN/OFQ mRNA was expressed at high levels in the subparafascicular thalamic nucleus, central gray, central tegmental field, auditory brainstem nuclei, caudal spinal trigeminal nucleus, and spinal dorsal horn.
Positive_regulation (levels) of Gene_expression (expressed) of N/OFQ in spinal trigeminal nucleus associated with medulla and spinal dorsal horn
6) Confidence 0.49 Published 2000 Journal J. Comp. Neurol. Section Abstract Doc Link 10906715 Disease Relevance 0.08 Pain Relevance 0.52
In 6-hydroxydopamine hemilesioned rats, enhancement of N/OFQ expression and release was detected in the lesioned compared with the unlesioned SN, indicating that parkinsonism may be associated with overactivation of the N/OFQ-NOP receptor system in the SN.
Positive_regulation (enhancement) of Gene_expression (expression) of N/OFQ associated with parkinson's disease and substantia nigra
7) Confidence 0.49 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16237164 Disease Relevance 0.59 Pain Relevance 0.86
Overexpression of a neuropeptide nociceptin/orphanin FQ precursor gene, N23K/N27K, induces neurite outgrowth in mouse NS20Y cells.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of neuropeptide nociceptin in NS20Y associated with orphanin and neuropeptide
8) Confidence 0.49 Published 1997 Journal J. Neurosci. Res. Section Title Doc Link 9185664 Disease Relevance 0 Pain Relevance 0.42
Overexpression of a neuropeptide nociceptin/orphanin FQ precursor gene, N23K/N27K, induces neurite outgrowth in mouse NS20Y cells.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of N27K (N27K) in NS20Y associated with orphanin and neuropeptide
9) Confidence 0.47 Published 1997 Journal J. Neurosci. Res. Section Title Doc Link 9185664 Disease Relevance 0 Pain Relevance 0.42
PreproN/OFQ mRNA was expressed at high levels in the subparafascicular thalamic nucleus, central gray, central tegmental field, auditory brainstem nuclei, caudal spinal trigeminal nucleus, and spinal dorsal horn.
Positive_regulation (levels) of in spinal Gene_expression (expressed) of N/OFQ in spinal trigeminal nucleus associated with medulla and spinal dorsal horn
10) Confidence 0.17 Published 2000 Journal J. Comp. Neurol. Section Abstract Doc Link 10906715 Disease Relevance 0.08 Pain Relevance 0.52

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