INT69943

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Context Info
Confidence 0.26
First Reported 1997
Last Reported 2010
Negated 0
Speculated 2
Reported most in Title
Documents 3
Total Number 5
Disease Relevance 0.98
Pain Relevance 3.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nqo1) oxidoreductase activity (Nqo1) aging (Nqo1)
cytoplasm (Nqo1)
Anatomy Link Frequency
spinal cord 2
dorsal horn 2
pituitary gland 2
Nqo1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 11 100.00 Very High Very High Very High
Versed 10 100.00 Very High Very High Very High
Spinal cord 8 99.04 Very High Very High Very High
Dorsal horn 4 98.28 Very High Very High Very High
Morphine 13 97.84 Very High Very High Very High
c fibre 4 97.04 Very High Very High Very High
Central nervous system 1 94.24 High High
tail-flick 1 93.16 High High
tolerance 8 85.76 High High
ischemia 31 84.16 Quite High
Disease Link Frequency Relevance Heat
Nociception 2 96.52 Very High Very High Very High
Injury 28 85.12 High High
Cv Unclassified Under Development 31 84.16 Quite High
Reperfusion Injury 4 83.44 Quite High
Death 2 71.52 Quite High
Hypoxia 4 70.92 Quite High
Cv General 4 Under Development 1 62.96 Quite High
Cancer 4 61.52 Quite High
INFLAMMATION 2 48.60 Quite Low
Lymphedema 1 29.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of the Nqo1 gene is primarily regulated via antioxidant response element sequences in the promoter region.
Regulation (regulated) of Gene_expression (expression) of Nqo1
1) Confidence 0.26 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2894749 Disease Relevance 0.88 Pain Relevance 0.04
In this study, we examined the effect of acute capsaicin injection on nicotinamide adenine dinucleotide phosphate diaphorase (NADPH-d, a histochemical index of nitric oxide, NO, synthase) and Fos expression in the rat pituitary gland.
Spec (examined) Regulation (effect) of Gene_expression (expression) of diaphorase in pituitary gland associated with qutenza
2) Confidence 0.20 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 11090977 Disease Relevance 0 Pain Relevance 0.48
Capsaicin-induced effects on c-fos expression and NADPH-diaphorase activity in the feline spinal cord.
Regulation (effects) of Gene_expression (expression) of NADPH-diaphorase in spinal cord associated with qutenza and spinal cord
3) Confidence 0.13 Published 2005 Journal Eur. J. Pharmacol. Section Title Doc Link 16168409 Disease Relevance 0 Pain Relevance 0.60
Frequency-dependent expression of diaphorase staining and nNOS-immunoreactivity in rat dorsal horn neurones following C-fibre stimulation.
Regulation (dependent) of Gene_expression (expression) of diaphorase in dorsal horn associated with c fibre and dorsal horn
4) Confidence 0.06 Published 1997 Journal Neurosci. Lett. Section Title Doc Link 9185680 Disease Relevance 0 Pain Relevance 0.52
Immunocytochemistry, histochemistry and western blot were performed to determine the effect of midazolam on formalin-induced expression of Fos protein, nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) and nitric oxide synthase (NOS) in chronic morphine-tolerant rats, respectively.
Spec (determine) Regulation (effect) of Gene_expression (expression) of phosphate-diaphorase associated with versed and morphine
5) Confidence 0.01 Published 2005 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 15740792 Disease Relevance 0.10 Pain Relevance 1.91

General Comments

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