INT69944

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Context Info
Confidence 0.38
First Reported 1997
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 4.81
Pain Relevance 5.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ndp) extracellular region (Ndp) cellular_component (Ndp)
biological_process (Ndp)
Anatomy Link Frequency
cingulate cortex 2
horn 1
sciatic nerve 1
anterior 1
nerve 1
Ndp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
headache 199 100.00 Very High Very High Very High
Dorsal horn 5 100.00 Very High Very High Very High
Anterior cingulate cortex 4 99.80 Very High Very High Very High
Anterior cingulate 4 99.36 Very High Very High Very High
Pain 54 98.98 Very High Very High Very High
Spinal cord 2 98.88 Very High Very High Very High
Sciatic nerve 2 98.86 Very High Very High Very High
c fibre 4 98.20 Very High Very High Very High
Pain threshold 2 97.12 Very High Very High Very High
neuralgia 2 94.96 High High
Disease Link Frequency Relevance Heat
Headache 190 100.00 Very High Very High Very High
Sphenoid Sinusitis 1 99.90 Very High Very High Very High
Cognitive Disorder 4 99.36 Very High Very High Very High
Pain 46 98.98 Very High Very High Very High
Headache Disorders 69 98.24 Very High Very High Very High
Neuralgia 2 94.96 High High
Pituitary Apoplexy 1 93.40 High High
Vasculitis 2 92.96 High High
Cv General 4 Under Development 1 92.60 High High
Nociception 1 91.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our previous work strongly suggests that the NDP is generated in part by the cognitive division of the anterior cingulate cortex (ACCcd).
Positive_regulation (generated) of NDP in cingulate cortex associated with cognitive disorder and anterior cingulate cortex
1) Confidence 0.38 Published 2002 Journal Psychophysiology Section Abstract Doc Link 12212656 Disease Relevance 0.69 Pain Relevance 0.68
OBJECTIVE: The pain-related negative difference potential (NDP) is derived by subtracting sural nerve-evoked somatosensory evoked potentials elicited at the pain threshold level from those elicited at supra-pain threshold levels.
Positive_regulation (derived) of NDP in nerve associated with pain and pain threshold
2) Confidence 0.37 Published 1999 Journal Clin Neurophysiol Section Abstract Doc Link 10616116 Disease Relevance 0.37 Pain Relevance 0.48
Following axotomy, AP and NDP were decreased in the dorsal horn and increased in large cells in the dorsolateral motor nuclei while CO was decreased in ventral horn neuropil.
Positive_regulation (increased) of NDP in horn associated with dorsal horn
3) Confidence 0.35 Published 1998 Journal Neuroreport Section Abstract Doc Link 9507983 Disease Relevance 0 Pain Relevance 0.53
C-fibre stimulation of the sciatic nerve at a frequency of 0.01 Hz was followed by a significant increase in NDP-cell number in the spinal segment L3, whereas 0.1 and 1 Hz stimulation resulted in a significant decrease.
Positive_regulation (increase) of NDP in sciatic nerve associated with c fibre and sciatic nerve
4) Confidence 0.30 Published 1997 Journal Neurosci. Lett. Section Abstract Doc Link 9185680 Disease Relevance 0 Pain Relevance 0.53
These results and our earlier studies suggest that the ACCc activity generating the NDP is involved in detecting transient painful stimuli.
Positive_regulation (generating) of NDP in ACCc associated with pain and anterior cingulate cortex
5) Confidence 0.22 Published 2004 Journal Psychophysiology Section Abstract Doc Link 15318881 Disease Relevance 0.60 Pain Relevance 0.97
These results provide further support for our hypothesis that the NDP is generated in part by the anterior cingulate, and suggest that the anterior cingulate response to pain reflects non-pain-specific cognitive processes (e.g., orienting attention towards important stimuli in the environment and/or response competition) and not some aspect of the pain experience.
Positive_regulation (generated) of NDP in anterior associated with pain, cognitive disorder and anterior cingulate
6) Confidence 0.10 Published 2001 Journal Psychophysiology Section Abstract Doc Link 11352133 Disease Relevance 0.78 Pain Relevance 0.86
These disorders rarely cause CDH, but can result in intractability of an ongoing headache attack.Sphenoid sinusitis may cause NDPH and may be missed radiologically unless appropriate studies are performed [10].Headaches that start after age 55 suggest an organic disorder for CDH, such as a mass lesion or giant cell arteritis [11].
Positive_regulation (cause) of NDPH associated with sphenoid sinusitis, headache and vasculitis
7) Confidence 0.05 Published 2007 Journal J Headache Pain Section Body Doc Link PMC2793374 Disease Relevance 2.38 Pain Relevance 1.55

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